Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           18    1135
NP_000240                                                              18    1135
NP_001161089                                                           18    1135
NP_055026                                                              17    2528
XP_005265931                                                           17    2528
XP_005265930                                                           17    2528
NP_919431                                                              17    3301
NP_001257711                                                           17    3301
NP_003192                                                              17    3301
NP_001269582                                                           17    4312
NP_001269581                                                           17    4312
NP_006810                                                              17    4312
NP_001161880                                                           17    4312
NP_001161879                                                           17    4312
NP_055804                                                              17    4312
NP_001161881                                                           17    4312
NP_001161882                                                           17    4312
NP_001161883                                                           17    4312
XP_006715455                                                           17    4312
XP_006715453                                                           17    4312
XP_005248748                                                           17    4312
XP_005248747                                                           17    4312
XP_006715452                                                           17    4312
XP_006715451                                                           17    4312
XP_006715450                                                           17    4312
XP_005248745                                                           17    4312
XP_005248744                                                           17    4312
XP_005248743                                                           17    4312
XP_005248742                                                           17    4312
XP_006715449                                                           17    4312
XP_006715448                                                           17    4312
XP_006715447                                                           17    4312
XP_006715446                                                           17    4312
NP_079133                                                              16    5631
NP_055986                                                              16    5631
NP_001257869                                                           16    5631
XP_005255254                                                           16    5631
XP_005255252                                                           16    5631
NP_009052                                                              16    7355
NP_001243576                                                           16    7355
NP_055794                                                              16    7355
NP_116229                                                              16    7355
XP_005248527                                                           16    7355
XP_005245617                                                           16    7355
XP_005245615                                                           16    7355
XP_005245614                                                           16    7355
XP_005245613                                                           16    7355
XP_005245616                                                           16    7355
NP_149093                                                              16    7355
NP_001228                                                              15    9605
NP_000327                                                              15    9605
NP_055558                                                              15    9605
NP_001094060                                                           15    9605
NP_001171588                                                           15    9605
NP_004888                                                              15    9605
NP_000129                                                              15    9605
NP_001202                                                              15    9605
NP_001104517                                                           15    9605
NP_001104516                                                           15    9605
NP_001104515                                                           15    9605
NP_001074008                                                           15    9605
NP_001007272                                                           15    9605
XP_005255524                                                           15    9605
XP_006718141                                                           15    9605
XP_005269940                                                           15    9605
XP_005248098                                                           15    9605
XP_006713998                                                           15    9605
XP_006713997                                                           15    9605
XP_006712502                                                           15    9605
XP_006712501                                                           15    9605
NP_065908                                                              15    9605
NP_001007273                                                           15    9605
NP_071376                                                              15    9605
NP_003905                                                              15    9605
>NP_001245200
          Length = 687

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LIEIGREDK 9
           LIEIG EDK
Sbjct: 228 LIEIGCEDK 236
>NP_000240
          Length = 756

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LIEIGREDK 9
           LIEIG EDK
Sbjct: 228 LIEIGCEDK 236
>NP_001161089
          Length = 658

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LIEIGREDK 9
           LIEIG EDK
Sbjct: 130 LIEIGCEDK 138
>NP_055026
          Length = 440

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IEIGREDK 9
          +E+GR DK
Sbjct: 28 VEVGRSDK 35
>XP_005265931
          Length = 238

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IEIGREDK 9
          +E+GR DK
Sbjct: 28 VEVGRSDK 35
>XP_005265930
          Length = 289

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IEIGREDK 9
          +E+GR DK
Sbjct: 28 VEVGRSDK 35
>NP_919431
          Length = 1717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L E+GRED+
Sbjct: 12 LPELGREDR 20
>NP_001257711
          Length = 214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +IE+GR+D
Sbjct: 190 MIEVGRKD 197
>NP_003192
          Length = 246

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +IE+GR+D
Sbjct: 222 MIEVGRKD 229
>NP_001269582
          Length = 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IEIGREDK 9
           IE+GRE++
Sbjct: 262 IEVGRENR 269
>NP_001269581
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IEIGREDK 9
           IE+GRE++
Sbjct: 333 IEVGRENR 340
>NP_006810
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IEIGREDK 9
           IE+GRE++
Sbjct: 286 IEVGRENR 293
>NP_001161880
          Length = 817

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IEIGREDK 9
           I+IG EDK
Sbjct: 667 IQIGMEDK 674
>NP_001161879
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IEIGREDK 9
           I+IG EDK
Sbjct: 862 IQIGMEDK 869
>NP_055804
          Length = 1692

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1542 IQIGMEDK 1549
>NP_001161881
          Length = 760

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IEIGREDK 9
           I+IG EDK
Sbjct: 610 IQIGMEDK 617
>NP_001161882
          Length = 826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IEIGREDK 9
           I+IG EDK
Sbjct: 676 IQIGMEDK 683
>NP_001161883
          Length = 219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IEIGREDK 9
          I+IG EDK
Sbjct: 69 IQIGMEDK 76
>XP_006715455
          Length = 474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IEIGREDK 9
           I+IG EDK
Sbjct: 324 IQIGMEDK 331
>XP_006715453
          Length = 1337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1187 IQIGMEDK 1194
>XP_005248748
          Length = 1343

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1193 IQIGMEDK 1200
>XP_005248747
          Length = 1367

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1217 IQIGMEDK 1224
>XP_006715452
          Length = 1474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1324 IQIGMEDK 1331
>XP_006715451
          Length = 1475

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1325 IQIGMEDK 1332
>XP_006715450
          Length = 1498

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1348 IQIGMEDK 1355
>XP_005248745
          Length = 1515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1365 IQIGMEDK 1372
>XP_005248744
          Length = 1519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1369 IQIGMEDK 1376
>XP_005248743
          Length = 1525

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1375 IQIGMEDK 1382
>XP_005248742
          Length = 1535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1385 IQIGMEDK 1392
>XP_006715449
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1389 IQIGMEDK 1396
>XP_006715448
          Length = 1549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1399 IQIGMEDK 1406
>XP_006715447
          Length = 1574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1424 IQIGMEDK 1431
>XP_006715446
          Length = 1574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IEIGREDK 9
            I+IG EDK
Sbjct: 1424 IQIGMEDK 1431
>NP_079133
          Length = 1844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L E+GR+D
Sbjct: 434 LYEVGRDD 441
>NP_055986
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +++IGR+D
Sbjct: 114 IVDIGRQD 121
>NP_001257869
          Length = 1111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +++IGR+D
Sbjct: 100 IVDIGRQD 107
>XP_005255254
          Length = 1051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LIEIGRED 8
          +++IGR+D
Sbjct: 40 IVDIGRQD 47
>XP_005255252
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +++IGR+D
Sbjct: 114 IVDIGRQD 121
>NP_009052
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IEIGREDK 9
           +++GRED+
Sbjct: 293 LQLGREDQ 300
>NP_001243576
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IEIGREDK 9
           +++GRED+
Sbjct: 196 LQLGREDQ 203
>NP_055794
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIEIGREDK 9
           L+E+G+ D+
Sbjct: 347 LLEVGKHDE 355
>NP_116229
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIGRED 8
           E+GRED
Sbjct: 202 ELGRED 207
>XP_005248527
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIEIGREDK 9
           L+E+G+ D+
Sbjct: 347 LLEVGKHDE 355
>XP_005245617
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>XP_005245615
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>XP_005245614
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>XP_005245613
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>XP_005245616
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>NP_149093
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIEIGREDK 9
          L+E+G E+K
Sbjct: 43 LLEVGVEEK 51
>NP_001228
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIEIGREDK 9
           L+E+G E K
Sbjct: 218 LVEVGEEYK 226
>NP_000327
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +++IG+ED
Sbjct: 298 ILDIGQED 305
>NP_055558
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L EIGR+D
Sbjct: 370 LKEIGRKD 377
>NP_001094060
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L EIGR+D
Sbjct: 370 LKEIGRKD 377
>NP_001171588
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L+E GR+D
Sbjct: 146 LVEKGRQD 153
>NP_004888
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L+E GR+D
Sbjct: 146 LVEKGRQD 153
>NP_000129
          Length = 2871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LIEIGRED 8
            LIE G ED
Sbjct: 2794 LIESGNED 2801
>NP_001202
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IEIGRED 8
           IE+G ED
Sbjct: 759 IELGNED 765
>NP_001104517
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIEIGREDK 9
           L+E+G E K
Sbjct: 207 LVEVGEEYK 215
>NP_001104516
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIEIGREDK 9
           L+E+G E K
Sbjct: 207 LVEVGEEYK 215
>NP_001104515
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIEIGREDK 9
           L+E+G E K
Sbjct: 250 LVEVGEEYK 258
>NP_001074008
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IEIGRED 8
           IE+GR D
Sbjct: 706 IELGRRD 712
>NP_001007272
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LIEIGREDK 9
          L E+G EDK
Sbjct: 6  LPELGGEDK 14
>XP_005255524
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIEIGRED 8
           +++IG+ED
Sbjct: 343 ILDIGQED 350
>XP_006718141
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L+E GR+D
Sbjct: 146 LVEKGRQD 153
>XP_005269940
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LIEIGREDK 9
          L E+G EDK
Sbjct: 6  LPELGGEDK 14
>XP_005248098
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L EIGR+D
Sbjct: 261 LKEIGRKD 268
>XP_006713998
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L EIGR+D
Sbjct: 370 LKEIGRKD 377
>XP_006713997
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIEIGRED 8
           L EIGR+D
Sbjct: 370 LKEIGRKD 377
>XP_006712502
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IEIGRED 8
           IE+GR D
Sbjct: 193 IELGRRD 199
>XP_006712501
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IEIGRED 8
           IE+GR D
Sbjct: 685 IELGRRD 691
>NP_065908
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  IEIGRED 8
          +E+GR+D
Sbjct: 90 VELGRKD 96
>NP_001007273
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LIEIGREDK 9
          L E+G EDK
Sbjct: 6  LPELGGEDK 14
>NP_071376
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IEIGREDK 9
            +++GRED+
Sbjct: 1017 MQLGREDQ 1024
>NP_003905
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIEIGREDK 9
           L+E+G E K
Sbjct: 251 LVEVGEEYK 259
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.149    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 649,238
Number of extensions: 1594
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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