Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              18    1482
NP_444254                                                              18    1482
NP_444253                                                              18    1482
NP_444255                                                              18    1482
XP_005247551                                                           18    1482
XP_005247550                                                           18    1482
XP_006713712                                                           18    1482
XP_005247549                                                           18    1482
NP_065789                                                              17    2528
NP_003237                                                              17    4312
NP_443116                                                              17    4312
NP_001128635                                                           17    4312
NP_653267                                                              17    4312
NP_055200                                                              17    4312
NP_149121                                                              17    4312
NP_001164632                                                           17    4312
NP_001164630                                                           17    4312
NP_001164629                                                           17    4312
NP_001164628                                                           17    4312
NP_001164627                                                           17    4312
NP_057627                                                              17    4312
XP_005259426                                                           17    4312
XP_005259424                                                           17    4312
XP_005259423                                                           17    4312
XP_006723203                                                           17    4312
XP_005258534                                                           17    4312
XP_005258533                                                           17    4312
NP_057095                                                              16    5631
NP_001019903                                                           16    5631
NP_001847                                                              16    5631
NP_443729                                                              16    5631
NP_201586                                                              16    5631
XP_005245943                                                           16    5631
XP_006710737                                                           16    5631
XP_005245946                                                           16    5631
XP_005245945                                                           16    5631
XP_005245944                                                           16    5631
XP_005245942                                                           16    5631
XP_005270538                                                           16    5631
NP_000058                                                              16    7355
NP_689865                                                              16    7355
NP_001201838                                                           16    7355
NP_001265454                                                           16    7355
NP_001265453                                                           16    7355
NP_055618                                                              16    7355
NP_001036009                                                           16    7355
NP_001036010                                                           16    7355
NP_003564                                                              16    7355
XP_005276585                                                           16    7355
XP_370934                                                              16    7355
XP_001716413                                                           16    7355
NP_001201835                                                           16    7355
NP_001209                                                              15    9605
NP_996808                                                              15    9605
NP_005398                                                              15    9605
NP_001278376                                                           15    9605
NP_001278375                                                           15    9605
NP_689829                                                              15    9605
NP_001034864                                                           15    9605
NP_001092082                                                           15    9605
NP_001185574                                                           15    9605
NP_001185573                                                           15    9605
NP_477514                                                              15    9605
NP_079130                                                              15    9605
NP_001003818                                                           15    9605
XP_005258568                                                           15    9605
XP_005268040                                                           15    9605
XP_006719216                                                           15    9605
XP_006713671                                                           15    9605
XP_005245975                                                           15    9605
NP_002793                                                              15    9605
NP_001135389                                                           15    9605
NP_789781                                                              15    9605
>NP_444256
          Length = 1794

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 389 LGSQDVVSK 397
>NP_444254
          Length = 1845

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 389 LGSQDVVSK 397
>NP_444253
          Length = 1914

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 389 LGSQDVVSK 397
>NP_444255
          Length = 1863

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 389 LGSQDVVSK 397
>XP_005247551
          Length = 1855

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 399 LGSQDVVSK 407
>XP_005247550
          Length = 1856

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 399 LGSQDVVSK 407
>XP_006713712
          Length = 1923

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 399 LGSQDVVSK 407
>XP_005247549
          Length = 1924

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGSQHVVSK 9
           LGSQ VVSK
Sbjct: 399 LGSQDVVSK 407
>NP_065789
          Length = 1771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    GSQHVVSK 9
            GSQH++S+
Sbjct: 1154 GSQHLISR 1161
>NP_003237
          Length = 1170

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GSQHVVS 8
           G QHVVS
Sbjct: 136 GKQHVVS 142
>NP_443116
          Length = 698

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 442 LGSQHV 447
>NP_001128635
          Length = 602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 442 LGSQHV 447
>NP_653267
          Length = 4753

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LGSQHVVSK 9
            LGS H++ K
Sbjct: 1609 LGSPHIIPK 1617
>NP_055200
          Length = 467

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 326 LGSQHV 331
>NP_149121
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 431 LGSQHV 436
>NP_001164632
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 283 LGSQHV 288
>NP_001164630
          Length = 544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 373 LGSQHV 378
>NP_001164629
          Length = 554

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 383 LGSQHV 388
>NP_001164628
          Length = 602

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 431 LGSQHV 436
>NP_001164627
          Length = 639

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 373 LGSQHV 378
>NP_057627
          Length = 374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 233 LGSQHV 238
>XP_005259426
          Length = 512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 341 LGSQHV 346
>XP_005259424
          Length = 549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 283 LGSQHV 288
>XP_005259423
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 341 LGSQHV 346
>XP_006723203
          Length = 343

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 326 LGSQHV 331
>XP_005258534
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 466 LGSQHV 471
>XP_005258533
          Length = 706

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQHV
Sbjct: 450 LGSQHV 455
>NP_057095
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 231 LGAEHVITE 239
>NP_001019903
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>NP_001847
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LGSQHVVS 8
           +G+QH+VS
Sbjct: 563 VGAQHLVS 570
>NP_443729
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQH+
Sbjct: 452 LGSQHI 457
>NP_201586
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQH+
Sbjct: 334 LGSQHI 339
>XP_005245943
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>XP_006710737
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>XP_005245946
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>XP_005245945
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>XP_005245944
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 155 LGAEHVITE 163
>XP_005245942
          Length = 401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LGSQHVVSK 9
           LG++HV+++
Sbjct: 259 LGAEHVITE 267
>XP_005270538
          Length = 1588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LGSQHVVS 8
           +G+QH+VS
Sbjct: 563 VGAQHLVS 570
>NP_000058
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           GS+H V K
Sbjct: 104 GSEHTVDK 111
>NP_689865
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LGSQHVVSK 9
          LGS++V+S+
Sbjct: 28 LGSENVISQ 36
>NP_001201838
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LGSQHVVSK 9
          LGS++V+S+
Sbjct: 28 LGSENVISQ 36
>NP_001265454
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           G QH+V K
Sbjct: 452 GKQHIVLK 459
>NP_001265453
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           G QH+V K
Sbjct: 452 GKQHIVLK 459
>NP_055618
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           G QH+V K
Sbjct: 452 GKQHIVLK 459
>NP_001036009
          Length = 1624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SQHVVSK 9
           SQHV+S+
Sbjct: 398 SQHVISE 404
>NP_001036010
          Length = 1557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SQHVVSK 9
           SQHV+S+
Sbjct: 331 SQHVISE 337
>NP_003564
          Length = 1587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SQHVVSK 9
           SQHV+S+
Sbjct: 361 SQHVISE 367
>XP_005276585
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSQHVVS 8
           G+QHVV+
Sbjct: 494 GAQHVVT 500
>XP_370934
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSQHVVS 8
           G+QHVV+
Sbjct: 494 GAQHVVT 500
>XP_001716413
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GSQHVVS 8
           G+QHVV+
Sbjct: 517 GAQHVVT 523
>NP_001201835
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LGSQHVVSK 9
          LGS++V+S+
Sbjct: 28 LGSENVISQ 36
>NP_001209
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GSQHVVS 8
           GS+H VS
Sbjct: 130 GSEHTVS 136
>NP_996808
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GSQHVVS 8
           GS+H VS
Sbjct: 130 GSEHTVS 136
>NP_005398
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 281 LGSQHPFS 288
>NP_001278376
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 144 LGSQHPFS 151
>NP_001278375
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 146 LGSQHPFS 153
>NP_689829
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LGSQHVVSK 9
           LG+QH+  +
Sbjct: 527 LGNQHIYQR 535
>NP_001034864
          Length = 1661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GSQHVVSK 9
            G QH++S+
Sbjct: 1406 GDQHILSE 1413
>NP_001092082
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LGSQHV 6
           LGSQH+
Sbjct: 325 LGSQHL 330
>NP_001185574
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 170 LGSQHFSS 177
>NP_001185573
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 170 LGSQHFSS 177
>NP_477514
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 345 LGSQHFSS 352
>NP_079130
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           G+QHV  K
Sbjct: 102 GNQHVYKK 109
>NP_001003818
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 373 LGSQHFSS 380
>XP_005258568
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSQHVVSK 9
           GSQ +VSK
Sbjct: 266 GSQDLVSK 273
>XP_005268040
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LGSQHVVS 8
           LGSQH  S
Sbjct: 279 LGSQHPFS 286
>XP_006719216
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           G+QHV  K
Sbjct: 102 GNQHVYKK 109
>XP_006713671
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LGSQHVVSK 9
           LG+QH+  +
Sbjct: 380 LGNQHIYQR 388
>XP_005245975
          Length = 1661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GSQHVVSK 9
            G QH++S+
Sbjct: 1406 GDQHILSE 1413
>NP_002793
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGSQHVVS 8
           +GS+H VS
Sbjct: 127 VGSEHYVS 134
>NP_001135389
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GSQHVVSK 9
           GS H VSK
Sbjct: 987 GSAHSVSK 994
>NP_789781
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GSQHVVSK 9
           GSQ +VSK
Sbjct: 266 GSQDLVSK 273
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.123    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 608,424
Number of extensions: 654
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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