Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              19     665
NP_002429                                                              18    1935
NP_001275949                                                           17    2528
NP_659464                                                              17    2528
XP_005248961                                                           17    2528
NP_056285                                                              17    3301
NP_663788                                                              17    3301
NP_001106984                                                           17    3301
NP_001106983                                                           17    3301
XP_006720022                                                           17    3301
XP_005254151                                                           17    3301
XP_005254150                                                           17    3301
XP_006720021                                                           17    3301
XP_005254149                                                           17    3301
XP_005254146                                                           17    3301
XP_006720020                                                           17    3301
XP_005254145                                                           17    3301
XP_005254143                                                           17    3301
XP_005254142                                                           17    3301
XP_005264310                                                           17    3301
XP_005264309                                                           17    3301
XP_005264308                                                           17    3301
XP_006712048                                                           17    3301
NP_116107                                                              17    4312
XP_005264089                                                           17    4312
NP_116205                                                              16    5631
XP_005259403                                                           16    5631
XP_005259401                                                           16    5631
NP_001138571                                                           16    7355
NP_060055                                                              16    7355
NP_060700                                                              16    7355
NP_115627                                                              15    9605
NP_001138600                                                           15    9605
NP_000947                                                              15    9605
NP_001269633                                                           15    9605
NP_001269634                                                           15    9605
NP_038476                                                              15    9605
NP_002883                                                              15    9605
NP_075377                                                              15    9605
NP_075376                                                              15    9605
NP_003386                                                              15    9605
NP_872589                                                              15    9605
XP_006723602                                                           15    9605
XP_005260717                                                           15    9605
XP_005268022                                                           15    9605
XP_005268021                                                           15    9605
XP_006718995                                                           15    9605
XP_006718993                                                           15    9605
XP_005274424                                                           15    9605
XP_005274423                                                           15    9605
XP_006718583                                                           15    9605
XP_006718582                                                           15    9605
XP_006717419                                                           15    9605
XP_006715439                                                           15    9605
XP_005270437                                                           15    9605
NP_006408                                                              15    9605
NP_115828                                                              15    9605
NP_001139500                                                           15    9605
NP_203753                                                              15    9605
NP_542789                                                              15    9605
>NP_073713
          Length = 985

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGRRSSLMY 9
          LGRRSSL Y
Sbjct: 35 LGRRSSLTY 43
>NP_002429
          Length = 1456

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    GRRSSLMY 9
            GRRSSL Y
Sbjct: 1040 GRRSSLSY 1047
>NP_001275949
          Length = 797

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LGRRSSLMY 9
           LG+RSSL++
Sbjct: 537 LGKRSSLLH 545
>NP_659464
          Length = 814

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LGRRSSLMY 9
           LG+RSSL++
Sbjct: 537 LGKRSSLLH 545
>XP_005248961
          Length = 842

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LGRRSSLMY 9
           LG+RSSL++
Sbjct: 537 LGKRSSLLH 545
>NP_056285
          Length = 653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 477 LGRRSSL 483
>NP_663788
          Length = 782

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 735 LGRRSSL 741
>NP_001106984
          Length = 753

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 706 LGRRSSL 712
>NP_001106983
          Length = 803

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 756 LGRRSSL 762
>XP_006720022
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 590 LGRRSSL 596
>XP_005254151
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 590 LGRRSSL 596
>XP_005254150
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 590 LGRRSSL 596
>XP_006720021
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 590 LGRRSSL 596
>XP_005254149
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 590 LGRRSSL 596
>XP_005254146
          Length = 792

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 665 LGRRSSL 671
>XP_006720020
          Length = 798

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 671 LGRRSSL 677
>XP_005254145
          Length = 802

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 675 LGRRSSL 681
>XP_005254143
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 735 LGRRSSL 741
>XP_005254142
          Length = 874

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 747 LGRRSSL 753
>XP_005264310
          Length = 531

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 477 LGRRSSL 483
>XP_005264309
          Length = 1324

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 477 LGRRSSL 483
>XP_005264308
          Length = 1218

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 477 LGRRSSL 483
>XP_006712048
          Length = 1249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           LGRRSSL
Sbjct: 477 LGRRSSL 483
>NP_116107
          Length = 474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGRRSSLM 8
           +GRRSSL+
Sbjct: 106 VGRRSSLL 113
>XP_005264089
          Length = 413

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LGRRSSLM 8
          +GRRSSL+
Sbjct: 45 VGRRSSLL 52
>NP_116205
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           +GRRSSL
Sbjct: 109 MGRRSSL 115
>XP_005259403
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           +GRRSSL
Sbjct: 109 MGRRSSL 115
>XP_005259401
          Length = 759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGRRSSL 7
           +GRRSSL
Sbjct: 109 MGRRSSL 115
>NP_001138571
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LGRRSSLMY 9
           LGR+ S+M+
Sbjct: 106 LGRKLSIMF 114
>NP_060055
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LGRRSSLMY 9
           LGR+ S+M+
Sbjct: 106 LGRKLSIMF 114
>NP_060700
          Length = 1156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LGRRSSL 7
          +GRRSSL
Sbjct: 52 VGRRSSL 58
>NP_115627
          Length = 1476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 593 GRRSSL 598
>NP_001138600
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRSSLMY 9
            RRS+L+Y
Sbjct: 1832 RRSALLY 1838
>NP_000947
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GRRSSL 7
          GRRSSL
Sbjct: 59 GRRSSL 64
>NP_001269633
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LGRRSSLMY 9
          L R+S +MY
Sbjct: 41 LSRKSPIMY 49
>NP_001269634
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LGRRSSLMY 9
          L R+S +MY
Sbjct: 37 LSRKSPIMY 45
>NP_038476
          Length = 1556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1421 LGRRSS 1426
>NP_002883
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_075377
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_075376
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_003386
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGRRSS 6
           LGRRSS
Sbjct: 183 LGRRSS 188
>NP_872589
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1389 LGRRSS 1394
>XP_006723602
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LGRRSS 6
          LGRRSS
Sbjct: 56 LGRRSS 61
>XP_005260717
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LGRRSS 6
          LGRRSS
Sbjct: 56 LGRRSS 61
>XP_005268022
          Length = 1208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 143 GRRSSL 148
>XP_005268021
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 143 GRRSSL 148
>XP_006718995
          Length = 2382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1605 LGRRSS 1610
>XP_006718993
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1825 LGRRSS 1830
>XP_005274424
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1838 LGRRSS 1843
>XP_005274423
          Length = 2615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1838 LGRRSS 1843
>XP_006718583
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 515 GRRSSL 520
>XP_006718582
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 593 GRRSSL 598
>XP_006717419
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 284 GRRSSL 289
>XP_006715439
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRSSLMY 9
            RRS+L+Y
Sbjct: 1832 RRSALLY 1838
>XP_005270437
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRRSSLMY 9
          G+R SL+Y
Sbjct: 21 GKRLSLLY 28
>NP_006408
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRRSSLMY 9
          G+R SL+Y
Sbjct: 21 GKRLSLLY 28
>NP_115828
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 232 GRRSSL 237
>NP_001139500
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GRRSSL 7
           GRRSSL
Sbjct: 232 GRRSSL 237
>NP_203753
          Length = 2601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRRSS 6
            LGRRSS
Sbjct: 1825 LGRRSS 1830
>NP_542789
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LGRRSS 6
          LGRRSS
Sbjct: 31 LGRRSS 36
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.140    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 350,518
Number of extensions: 366
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package