Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              20     509
NP_055192                                                              18    1482
NP_001123359                                                           18    1482
NP_694985                                                              17    2528
NP_006738                                                              17    2528
XP_005274246                                                           17    2528
XP_005263371                                                           17    4312
NP_001268421                                                           16    5631
NP_004509                                                              16    5631
NP_000525                                                              16    5631
NP_742106                                                              16    5631
NP_001121615                                                           16    5631
NP_001121616                                                           16    5631
NP_000170                                                              16    5631
NP_742105                                                              16    5631
NP_742104                                                              16    5631
NP_001268422                                                           16    5631
NP_001268423                                                           16    5631
XP_006723855                                                           16    5631
XP_006723854                                                           16    5631
XP_006723853                                                           16    5631
XP_006723852                                                           16    5631
XP_006723851                                                           16    5631
XP_006723850                                                           16    5631
XP_005246706                                                           16    5631
XP_005246704                                                           16    5631
XP_005264328                                                           16    5631
NP_005637                                                              16    7355
NP_937872                                                              16    7355
NP_060380                                                              16    7355
XP_006713969                                                           16    7355
XP_006713968                                                           16    7355
XP_005264451                                                           16    7355
XP_006712100                                                           16    7355
XP_005264450                                                           16    7355
XP_006711875                                                           16    7355
XP_005273291                                                           16    7355
NP_002917                                                              16    7355
NP_001120669                                                           15    9605
NP_001412                                                              15    9605
NP_001070650                                                           15    9605
NP_036550                                                              15    9605
NP_003122                                                              15    9605
NP_006178                                                              15    9605
NP_001099001                                                           15    9605
NP_065870                                                              15    9605
NP_001156001                                                           15    9605
XP_005262446                                                           15    9605
XP_005257253                                                           15    9605
XP_005257252                                                           15    9605
XP_005253946                                                           15    9605
XP_006715718                                                           15    9605
XP_005248808                                                           15    9605
XP_005248807                                                           15    9605
XP_005248806                                                           15    9605
XP_005248805                                                           15    9605
XP_005248804                                                           15    9605
XP_005248803                                                           15    9605
XP_005248802                                                           15    9605
XP_005248801                                                           15    9605
XP_005248800                                                           15    9605
>NP_003290
          Length = 803

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LGRGTAITL 9
           LGRGT ITL
Sbjct: 241 LGRGTTITL 249
>NP_055192
          Length = 621

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GRGTAIT 8
          GRGTAIT
Sbjct: 10 GRGTAIT 16
>NP_001123359
          Length = 568

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GRGTAIT 8
          GRGTAIT
Sbjct: 10 GRGTAIT 16
>NP_694985
          Length = 1042

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GRGTAITL 9
           GRG AITL
Sbjct: 652 GRGEAITL 659
>NP_006738
          Length = 1042

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GRGTAITL 9
           GRG AITL
Sbjct: 652 GRGEAITL 659
>XP_005274246
          Length = 1042

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GRGTAITL 9
           GRG AITL
Sbjct: 652 GRGEAITL 659
>XP_005263371
          Length = 526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LGRGTAITL 9
          LG GTA+ L
Sbjct: 70 LGTGTAVAL 78
>NP_001268421
          Length = 1230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRGTA 6
            LGRGTA
Sbjct: 1085 LGRGTA 1090
>NP_004509
          Length = 844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 565 VGRGPAIT 572
>NP_000525
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           LG+GT +T
Sbjct: 137 LGQGTTVT 144
>NP_742106
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 562 VGRGPAIT 569
>NP_001121615
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           LG+GT +T
Sbjct: 137 LGQGTTVT 144
>NP_001121616
          Length = 770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           LG+GT +T
Sbjct: 137 LGQGTTVT 144
>NP_000170
          Length = 1360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRGTA 6
            LGRGTA
Sbjct: 1215 LGRGTA 1220
>NP_742105
          Length = 872

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 593 VGRGPAIT 600
>NP_742104
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 575 VGRGPAIT 582
>NP_001268422
          Length = 1058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGRGTA 6
           LGRGTA
Sbjct: 913 LGRGTA 918
>NP_001268423
          Length = 1058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LGRGTA 6
           LGRGTA
Sbjct: 913 LGRGTA 918
>XP_006723855
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 577 VGRGPAIT 584
>XP_006723854
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 579 VGRGPAIT 586
>XP_006723853
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 589 VGRGPAIT 596
>XP_006723852
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 597 VGRGPAIT 604
>XP_006723851
          Length = 885

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 606 VGRGPAIT 613
>XP_006723850
          Length = 886

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           +GRG AIT
Sbjct: 607 VGRGPAIT 614
>XP_005246706
          Length = 891

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           LG+GT +T
Sbjct: 137 LGQGTTVT 144
>XP_005246704
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGRGTAIT 8
           LG+GT +T
Sbjct: 137 LGQGTTVT 144
>XP_005264328
          Length = 1261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LGRGTA 6
            LGRGTA
Sbjct: 1116 LGRGTA 1121
>NP_005637
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGRGTAI 7
           LGRGT++
Sbjct: 565 LGRGTSL 571
>NP_937872
          Length = 1447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GRGTAIT 8
           GRGT +T
Sbjct: 632 GRGTGLT 638
>NP_060380
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RGTAIT 8
           RGTAIT
Sbjct: 225 RGTAIT 230
>XP_006713969
          Length = 1157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GRGTAIT 8
           GRGT +T
Sbjct: 632 GRGTGLT 638
>XP_006713968
          Length = 1447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GRGTAIT 8
           GRGT +T
Sbjct: 632 GRGTGLT 638
>XP_005264451
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RGTAIT 8
           RGTAIT
Sbjct: 225 RGTAIT 230
>XP_006712100
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RGTAIT 8
           RGTAIT
Sbjct: 225 RGTAIT 230
>XP_005264450
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RGTAIT 8
           RGTAIT
Sbjct: 225 RGTAIT 230
>XP_006711875
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGRGTAI 7
           LGRGT++
Sbjct: 109 LGRGTSL 115
>XP_005273291
          Length = 1620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGRGTAI 7
           LGRGT++
Sbjct: 565 LGRGTSL 571
>NP_002917
          Length = 1376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GRGTAIT 8
           GRGT +T
Sbjct: 632 GRGTGLT 638
>NP_001120669
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LGRGTAITL 9
           +G G+A+TL
Sbjct: 411 VGSGSALTL 419
>NP_001412
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LGRGTAITL 9
           +G G+A+TL
Sbjct: 411 VGSGSALTL 419
>NP_001070650
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRGTAITL 9
          G+GTA+ L
Sbjct: 53 GQGTAVLL 60
>NP_036550
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRGTAITL 9
          G+GTA+ L
Sbjct: 53 GQGTAVLL 60
>NP_003122
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LGRGTAI 7
          LGRG+A+
Sbjct: 12 LGRGSAL 18
>NP_006178
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  GRGTAI 7
          GRGTA+
Sbjct: 64 GRGTAL 69
>NP_001099001
          Length = 1319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 766 GTAITL 771
>NP_065870
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 749 GTAITL 754
>NP_001156001
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 962 GTAITL 967
>XP_005262446
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LGRGTAITL 9
           +G G+A+TL
Sbjct: 411 VGSGSALTL 419
>XP_005257253
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRGTAITL 9
          G+GTA+ L
Sbjct: 53 GQGTAVLL 60
>XP_005257252
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GRGTAITL 9
          G+GTA+ L
Sbjct: 53 GQGTAVLL 60
>XP_005253946
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  GRGTAI 7
          GRGTA+
Sbjct: 64 GRGTAL 69
>XP_006715718
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GRGTAIT 8
           G GTA+T
Sbjct: 181 GHGTALT 187
>XP_005248808
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 568 GTAITL 573
>XP_005248807
          Length = 1182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 629 GTAITL 634
>XP_005248806
          Length = 1317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 764 GTAITL 769
>XP_005248805
          Length = 1345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 792 GTAITL 797
>XP_005248804
          Length = 1378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 825 GTAITL 830
>XP_005248803
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 902 GTAITL 907
>XP_005248802
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 962 GTAITL 967
>XP_005248801
          Length = 1541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 988 GTAITL 993
>XP_005248800
          Length = 1541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GTAITL 9
           GTAITL
Sbjct: 988 GTAITL 993
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.145    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 540,754
Number of extensions: 784
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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