Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     390
NP_001091680                                                           20     390
NP_001091679                                                           20     390
XP_006713048                                                           20     390
XP_006713047                                                           20     390
XP_006713046                                                           20     390
XP_005264943                                                           20     390
XP_006720914                                                           17    2528
NP_631909                                                              17    2528
NP_000177                                                              17    3301
NP_001014975                                                           17    3301
XP_006711346                                                           17    3301
XP_006711345                                                           17    3301
NP_115642                                                              17    4312
NP_005468                                                              16    5631
NP_001278236                                                           16    5631
NP_001243469                                                           16    5631
NP_001243468                                                           16    5631
NP_057475                                                              16    5631
NP_001278235                                                           16    5631
NP_001278237                                                           16    5631
NP_055642                                                              16    5631
NP_002421                                                              16    5631
XP_005250112                                                           16    5631
XP_006716197                                                           16    5631
XP_006716196                                                           16    5631
XP_006711736                                                           16    5631
XP_005245701                                                           16    5631
XP_005245700                                                           16    5631
NP_036388                                                              16    5631
NP_002105                                                              16    7355
NP_001128119                                                           16    7355
NP_940997                                                              16    7355
XP_005276585                                                           16    7355
XP_370934                                                              16    7355
XP_005249099                                                           16    7355
XP_006713972                                                           16    7355
XP_006713971                                                           16    7355
XP_001716413                                                           16    7355
NP_079317                                                              16    7355
NP_061871                                                              15    9605
NP_000284                                                              15    9605
NP_001027005                                                           15    9605
NP_004371                                                              15    9605
NP_001073315                                                           15    9605
NP_056477                                                              15    9605
NP_068741                                                              15    9605
NP_208384                                                              15    9605
NP_001032412                                                           15    9605
NP_065933                                                              15    9605
NP_001161686                                                           15    9605
XP_005256041                                                           15    9605
XP_005256040                                                           15    9605
XP_005255182                                                           15    9605
XP_006720911                                                           15    9605
XP_005255181                                                           15    9605
XP_005266147                                                           15    9605
XP_005266146                                                           15    9605
XP_005248944                                                           15    9605
XP_005248943                                                           15    9605
XP_005248942                                                           15    9605
XP_006712050                                                           15    9605
XP_005264311                                                           15    9605
XP_006712049                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 10 LDMAMEPDR 18
>NP_001091680
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 10 LDMAMEPDR 18
>NP_001091679
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 10 LDMAMEPDR 18
>XP_006713048
          Length = 720

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 10 LDMAMEPDR 18
>XP_006713047
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 3  LDMAMEPDR 11
>XP_006713046
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 3  LDMAMEPDR 11
>XP_005264943
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LGMAMEPDR 9
          L MAMEPDR
Sbjct: 10 LDMAMEPDR 18
>XP_006720914
          Length = 543

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LGMA EP R
Sbjct: 160 LGMAEEPPR 168
>NP_631909
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LGMA EP R
Sbjct: 137 LGMAEEPPR 145
>NP_000177
          Length = 1231

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AMEPDR 9
           AMEPDR
Sbjct: 161 AMEPDR 166
>NP_001014975
          Length = 449

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AMEPDR 9
           AMEPDR
Sbjct: 161 AMEPDR 166
>XP_006711346
          Length = 819

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AMEPDR 9
           AMEPDR
Sbjct: 161 AMEPDR 166
>XP_006711345
          Length = 1173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AMEPDR 9
           AMEPDR
Sbjct: 161 AMEPDR 166
>NP_115642
          Length = 1984

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LGM ++PD
Sbjct: 193 LGMLLQPD 200
>NP_005468
          Length = 1203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMAMEPDR 9
           G+A EP+R
Sbjct: 147 GLAAEPER 154
>NP_001278236
          Length = 138

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_001243469
          Length = 231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_001243468
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_057475
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_001278235
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_001278237
          Length = 99

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LGMAMEPDR 9
          +G+A++P+R
Sbjct: 56 MGLAVDPNR 64
>NP_055642
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LGM+ +PD
Sbjct: 335 LGMSADPD 342
>NP_002421
          Length = 1320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LGMAMEP 7
          LGM MEP
Sbjct: 61 LGMNMEP 67
>XP_005250112
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMAMEPDR 9
           G+A+EP R
Sbjct: 429 GLALEPGR 436
>XP_006716197
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMAMEPDR 9
           G+A+EP R
Sbjct: 488 GLALEPGR 495
>XP_006716196
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMAMEPDR 9
           G+A+EP R
Sbjct: 489 GLALEPGR 496
>XP_006711736
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LGM+ +PD
Sbjct: 335 LGMSADPD 342
>XP_005245701
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LGM+ +PD
Sbjct: 335 LGMSADPD 342
>XP_005245700
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LGM+ +PD
Sbjct: 335 LGMSADPD 342
>NP_036388
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMAMEPDR 9
           G+A+EP R
Sbjct: 483 GLALEPGR 490
>NP_002105
          Length = 2718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LG+ ++PD
Sbjct: 462 LGLVLQPD 469
>NP_001128119
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGMAMEP 7
           LG+A+EP
Sbjct: 737 LGLAIEP 743
>NP_940997
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGMAMEP 7
           LG+A+EP
Sbjct: 653 LGLAIEP 659
>XP_005276585
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LGMAMEPD 8
          LG+A +PD
Sbjct: 85 LGLAPDPD 92
>XP_370934
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LGMAMEPD 8
          LG+A +PD
Sbjct: 85 LGLAPDPD 92
>XP_005249099
          Length = 2026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           LG+ ++PD
Sbjct: 462 LGLVLQPD 469
>XP_006713972
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGMAMEP 7
           LG+A+EP
Sbjct: 674 LGLAIEP 680
>XP_006713971
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LGMAMEP 7
           LG+A+EP
Sbjct: 758 LGLAIEP 764
>XP_001716413
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LGMAMEPD 8
          LG+A +PD
Sbjct: 85 LGLAPDPD 92
>NP_079317
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  GMAMEP 7
          GMA+EP
Sbjct: 43 GMALEP 48
>NP_061871
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   LGMAMEPD 8
           +GM + PD
Sbjct: 406 IGMGLSPD 413
>NP_000284
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LG++  PDR
Sbjct: 547 LGLSGRPDR 555
>NP_001027005
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LG++  PDR
Sbjct: 540 LGLSGRPDR 548
>NP_004371
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMAMEPDR 9
           GMA+ P R
Sbjct: 761 GMAISPSR 768
>NP_001073315
          Length = 2404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMAMEPDR 9
           GMA+ P R
Sbjct: 723 GMAISPSR 730
>NP_056477
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  GMAMEPD 8
          GMA  PD
Sbjct: 71 GMAFSPD 77
>NP_068741
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           L MA+EP+
Sbjct: 512 LAMALEPN 519
>NP_208384
          Length = 2080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GMAMEPD 8
            GMA EP+
Sbjct: 1794 GMATEPE 1800
>NP_001032412
          Length = 2649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GMAMEPD 8
            GMA EP+
Sbjct: 2363 GMATEPE 2369
>NP_065933
          Length = 1284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GMAMEP 7
           G+AMEP
Sbjct: 861 GVAMEP 866
>NP_001161686
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GMAMEPD 8
           G+A EPD
Sbjct: 232 GVAAEPD 238
>XP_005256041
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LG++  PDR
Sbjct: 540 LGLSGRPDR 548
>XP_005256040
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LGMAMEPDR 9
           LG++  PDR
Sbjct: 547 LGLSGRPDR 555
>XP_005255182
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMAMEPDR 9
           GMA+ P R
Sbjct: 761 GMAISPSR 768
>XP_006720911
          Length = 2355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMAMEPDR 9
           GMA+ P R
Sbjct: 761 GMAISPSR 768
>XP_005255181
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMAMEPDR 9
           GMA+ P R
Sbjct: 746 GMAISPSR 753
>XP_005266147
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   LGMAMEPD 8
           +GM + PD
Sbjct: 498 IGMGLSPD 505
>XP_005266146
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   LGMAMEPD 8
           +GM + PD
Sbjct: 508 IGMGLSPD 515
>XP_005248944
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           L MA+EP+
Sbjct: 470 LAMALEPN 477
>XP_005248943
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           L MA+EP+
Sbjct: 489 LAMALEPN 496
>XP_005248942
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGMAMEPD 8
           L MA+EP+
Sbjct: 505 LAMALEPN 512
>XP_006712050
          Length = 1716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  GMAMEPD 8
          GMA  PD
Sbjct: 71 GMAFSPD 77
>XP_005264311
          Length = 1727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  GMAMEPD 8
          GMA  PD
Sbjct: 71 GMAFSPD 77
>XP_006712049
          Length = 1728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  GMAMEPD 8
          GMA  PD
Sbjct: 50 GMAFSPD 56
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.138    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 759,369
Number of extensions: 1019
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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