Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_997213                                                              17    4312
NP_112184                                                              16    5631
NP_001171817                                                           16    5631
NP_001008892                                                           16    5631
NP_001008894                                                           16    5631
NP_001008860                                                           16    5631
NP_001171818                                                           16    5631
XP_006720431                                                           16    5631
XP_006720430                                                           16    5631
XP_006720429                                                           16    5631
XP_005272610                                                           16    5631
XP_005272609                                                           16    5631
XP_006720428                                                           16    5631
XP_005272606                                                           16    5631
XP_005272605                                                           16    5631
XP_005272607                                                           16    5631
XP_006720427                                                           16    5631
XP_005272604                                                           16    5631
XP_005272603                                                           16    5631
NP_001073960                                                           16    7355
NP_055503                                                              16    7355
NP_001193620                                                           16    7355
NP_998759                                                              16    7355
XP_006717605                                                           16    7355
NP_115880                                                              16    7355
NP_000375                                                              15    9605
NP_000184                                                              15    9605
NP_689905                                                              15    9605
NP_001011551                                                           15    9605
XP_006726390                                                           15    9605
XP_006726389                                                           15    9605
XP_006726388                                                           15    9605
XP_006726387                                                           15    9605
XP_006711142                                                           15    9605
XP_006711141                                                           15    9605
XP_006711140                                                           15    9605
XP_006710131                                                           15    9605
XP_006710130                                                           15    9605
XP_006710129                                                           15    9605
XP_006710128                                                           15    9605
NP_789791                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LGLAIKES 8
            LGLAIKES
Sbjct: 2261 LGLAIKES 2268
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LGLAIKES 8
            LGLAIKES
Sbjct: 2253 LGLAIKES 2260
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LGLAIKES 8
            LGLAIKES
Sbjct: 2214 LGLAIKES 2221
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LGLAIKES 8
            LGLAIKES
Sbjct: 2293 LGLAIKES 2300
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LGLAIKES 8
            LGLAIKES
Sbjct: 2306 LGLAIKES 2313
>NP_997213
          Length = 410

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGLAIKESV 9
           LG+AIKE +
Sbjct: 257 LGIAIKELI 265
>NP_112184
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>NP_001171817
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 180 LGIAIKE 186
>NP_001008892
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>NP_001008894
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 180 LGIAIKE 186
>NP_001008860
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>NP_001171818
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_006720431
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 113 LGIAIKE 119
>XP_006720430
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 180 LGIAIKE 186
>XP_006720429
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272610
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272609
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_006720428
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272606
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272605
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272607
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_006720427
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272604
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>XP_005272603
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LG+AIKE
Sbjct: 199 LGIAIKE 205
>NP_001073960
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   GLAIKESV 9
           GL+I+ESV
Sbjct: 836 GLSIQESV 843
>NP_055503
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   GLAIKESV 9
           GL+I+ESV
Sbjct: 819 GLSIQESV 826
>NP_001193620
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GLAIKES 8
           G+A+KES
Sbjct: 140 GIAVKES 146
>NP_998759
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GLAIKES 8
           G+A+KES
Sbjct: 131 GIAVKES 137
>XP_006717605
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   GLAIKESV 9
           GL+I+ESV
Sbjct: 847 GLSIQESV 854
>NP_115880
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GLAIKES 8
          G+A+KES
Sbjct: 37 GIAVKES 43
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LAIKESV 9
            LA+KESV
Sbjct: 2822 LALKESV 2828
>NP_000184
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGLAIKES 8
           LG+A+K S
Sbjct: 455 LGMAVKSS 462
>NP_689905
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LGLAIKESV 9
           +GL+IKE++
Sbjct: 251 VGLSIKEAM 259
>NP_001011551
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LGLAIKESV 9
           +GL+IKE++
Sbjct: 251 VGLSIKEAM 259
>XP_006726390
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006726389
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006726388
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006726387
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006711142
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006711141
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006711140
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006710131
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006710130
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006710129
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>XP_006710128
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LGLAIKES 8
          LGLA+K++
Sbjct: 82 LGLALKDT 89
>NP_789791
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGLAIKE 7
           LGLAIK+
Sbjct: 454 LGLAIKK 460
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.137    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,965
Number of extensions: 592
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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