Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_775871                                                              17    4312
NP_003244                                                              16    5631
NP_056227                                                              16    5631
XP_005261097                                                           16    5631
XP_005261096                                                           16    5631
XP_005261095                                                           16    5631
XP_005261094                                                           16    5631
XP_005247330                                                           16    5631
NP_037450                                                              16    7355
NP_001277247                                                           16    7355
NP_065708                                                              16    7355
NP_001277248                                                           16    7355
NP_001165339                                                           16    7355
NP_001003682                                                           16    7355
NP_001136205                                                           16    7355
XP_006726491                                                           16    7355
XP_006715877                                                           16    7355
XP_006713045                                                           16    7355
XP_005264942                                                           16    7355
XP_005264941                                                           16    7355
XP_006710244                                                           16    7355
NP_620482                                                              15    9605
NP_001077084                                                           15    9605
NP_057438                                                              15    9605
XP_005260260                                                           15    9605
XP_006712362                                                           15    9605
NP_003183                                                              15    9605
>NP_775871
          Length = 8384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    AAIVKDC 9
            AA+V+DC
Sbjct: 8260 AAVVQDC 8266
>NP_003244
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGAAIVKDC 9
           LG+A  KDC
Sbjct: 200 LGSAEEKDC 208
>NP_056227
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  AAIVKDC 9
          AA++K+C
Sbjct: 40 AAVIKEC 46
>XP_005261097
          Length = 1452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGAAIVKDC 9
           LG+A  KDC
Sbjct: 200 LGSAEEKDC 208
>XP_005261096
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGAAIVKDC 9
           LG+A  KDC
Sbjct: 200 LGSAEEKDC 208
>XP_005261095
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGAAIVKDC 9
           LG+A  KDC
Sbjct: 200 LGSAEEKDC 208
>XP_005261094
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGAAIVKDC 9
           LG+A  KDC
Sbjct: 200 LGSAEEKDC 208
>XP_005247330
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  AAIVKDC 9
          AA++K+C
Sbjct: 40 AAVIKEC 46
>NP_037450
          Length = 2229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    GAAIVKDC 9
            G+AI+++C
Sbjct: 1537 GSAIIENC 1544
>NP_001277247
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GAAIVKDC 9
           GA+ VK C
Sbjct: 198 GASFVKSC 205
>NP_065708
          Length = 659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GAAIVKDC 9
           GA+ VK C
Sbjct: 151 GASFVKSC 158
>NP_001277248
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GAAIVKDC 9
           GA+ VK C
Sbjct: 109 GASFVKSC 116
>NP_001165339
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LGAAIVKDC 9
           LGA   +DC
Sbjct: 270 LGAPAARDC 278
>NP_001003682
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LGAAIVKDC 9
           LGA   +DC
Sbjct: 270 LGAPAARDC 278
>NP_001136205
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AAIVKDC 9
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_006726491
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GAAIVKDC 9
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>XP_006715877
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GAAIVKDC 9
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>XP_006713045
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AAIVKDC 9
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_005264942
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AAIVKDC 9
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_005264941
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AAIVKDC 9
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_006710244
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GAAIVKDC 9
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>NP_620482
          Length = 1341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GAAIVKDC 9
            G+A V+DC
Sbjct: 1143 GSAEVQDC 1150
>NP_001077084
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GAAIVKDC 9
            G+A V+DC
Sbjct: 1116 GSAEVQDC 1123
>NP_057438
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GAAIVKDC 9
           G+A++K C
Sbjct: 451 GSAVIKFC 458
>XP_005260260
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GAAIVKDC 9
           G+A++K C
Sbjct: 451 GSAVIKFC 458
>XP_006712362
          Length = 1350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GAAIVKDC 9
            G+A V+DC
Sbjct: 1152 GSAEVQDC 1159
>NP_003183
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIVKDC 9
           AIV+DC
Sbjct: 279 AIVEDC 284
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.143    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 450,579
Number of extensions: 695
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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