Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           18    1135
NP_000242                                                              18    1135
XP_005264389                                                           18    1135
XP_006725230                                                           17    4312
XP_006720283                                                           17    4312
XP_005267569                                                           17    4312
XP_005267568                                                           17    4312
XP_006720170                                                           17    4312
XP_006720169                                                           17    4312
NP_065869                                                              17    4312
NP_001129514                                                           16    5631
NP_079543                                                              16    5631
NP_001264049                                                           16    5631
NP_001248363                                                           16    5631
NP_001071062                                                           16    7355
NP_001091995                                                           16    7355
NP_001158058                                                           16    7355
NP_001025025                                                           16    7355
NP_001025022                                                           16    7355
NP_060674                                                              16    7355
NP_003710                                                              16    7355
NP_001025023                                                           16    7355
XP_006720367                                                           16    7355
XP_005266401                                                           16    7355
XP_005266400                                                           16    7355
XP_006715623                                                           16    7355
XP_006715622                                                           16    7355
XP_005267190                                                           16    7355
XP_005267189                                                           16    7355
XP_005267187                                                           16    7355
XP_005267185                                                           16    7355
XP_005267184                                                           16    7355
XP_005248681                                                           16    7355
XP_005248680                                                           16    7355
XP_006714790                                                           16    7355
XP_005248678                                                           16    7355
XP_006714789                                                           16    7355
XP_006714788                                                           16    7355
XP_006711681                                                           16    7355
XP_006711680                                                           16    7355
XP_005245637                                                           16    7355
NP_001025024                                                           16    7355
NP_009055                                                              16    7355
NP_001273615                                                           16    7355
NP_001026                                                              15    9605
NP_004357                                                              15    9605
NP_001164560                                                           15    9605
NP_001164559                                                           15    9605
NP_001164558                                                           15    9605
XP_005247181                                                           15    9605
XP_006713553                                                           15    9605
XP_006713552                                                           15    9605
XP_006713551                                                           15    9605
XP_006711873                                                           15    9605
XP_006711872                                                           15    9605
XP_006711871                                                           15    9605
XP_006711870                                                           15    9605
XP_006711869                                                           15    9605
XP_006711868                                                           15    9605
XP_006711867                                                           15    9605
XP_006711866                                                           15    9605
XP_006711865                                                           15    9605
NP_001862                                                              15    9605
>NP_001245210
          Length = 868

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LFQVSVEDT 9
           LFQ SVEDT
Sbjct: 246 LFQGSVEDT 254
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LFQVSVEDT 9
           LFQ SVEDT
Sbjct: 312 LFQGSVEDT 320
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LFQVSVEDT 9
           LFQ SVEDT
Sbjct: 312 LFQGSVEDT 320
>XP_006725230
          Length = 2636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSVED
Sbjct: 1685 LVQVSVED 1692
>XP_006720283
          Length = 2636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSVED
Sbjct: 1685 LVQVSVED 1692
>XP_005267569
          Length = 1340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FQVSVED 8
           FQVS+ED
Sbjct: 520 FQVSLED 526
>XP_005267568
          Length = 1340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FQVSVED 8
           FQVS+ED
Sbjct: 520 FQVSLED 526
>XP_006720170
          Length = 1354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FQVSVED 8
           FQVS+ED
Sbjct: 534 FQVSLED 540
>XP_006720169
          Length = 1361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   FQVSVED 8
           FQVS+ED
Sbjct: 541 FQVSLED 547
>NP_065869
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSVED
Sbjct: 1507 LVQVSVED 1514
>NP_001129514
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV +EDT
Sbjct: 215 FQVVLEDT 222
>NP_079543
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV +EDT
Sbjct: 154 FQVVLEDT 161
>NP_001264049
          Length = 127

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LFQVSVED 8
          LFQ+ VED
Sbjct: 89 LFQMHVED 96
>NP_001248363
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FQVSVEDT 9
          FQV +EDT
Sbjct: 41 FQVVLEDT 48
>NP_001071062
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LFQVSVEDT 9
          L QVS EDT
Sbjct: 65 LTQVSKEDT 73
>NP_001091995
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QVSVEDT 9
           +VS+EDT
Sbjct: 532 EVSIEDT 538
>NP_001158058
          Length = 3708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFQVSVED 8
           ++QV VED
Sbjct: 287 IYQVKVED 294
>NP_001025025
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 646 FQLTVKDT 653
>NP_001025022
          Length = 788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 596 FQLTVKDT 603
>NP_060674
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QVSVEDT 9
           +VS+EDT
Sbjct: 531 EVSIEDT 537
>NP_003710
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 693 FQLTVKDT 700
>NP_001025023
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 638 FQLTVKDT 645
>XP_006720367
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LFQVSVEDT 9
          L QVS EDT
Sbjct: 65 LTQVSKEDT 73
>XP_005266401
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QVSVEDT 9
           +VS+EDT
Sbjct: 484 EVSIEDT 490
>XP_005266400
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QVSVEDT 9
           +VS+EDT
Sbjct: 526 EVSIEDT 532
>XP_006715623
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LFQVSVED 8
           L QVSV+D
Sbjct: 307 LLQVSVDD 314
>XP_006715622
          Length = 2499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 1849 LLQVSVDD 1856
>XP_005267190
          Length = 3424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2774 LLQVSVDD 2781
>XP_005267189
          Length = 3425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2788 LLQVSVDD 2795
>XP_005267187
          Length = 3433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2783 LLQVSVDD 2790
>XP_005267185
          Length = 3437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2787 LLQVSVDD 2794
>XP_005267184
          Length = 3438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2788 LLQVSVDD 2795
>XP_005248681
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 591 FQLTVKDT 598
>XP_005248680
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 592 FQLTVKDT 599
>XP_006714790
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 667 FQLTVKDT 674
>XP_005248678
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 692 FQLTVKDT 699
>XP_006714789
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 713 FQLTVKDT 720
>XP_006714788
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 714 FQLTVKDT 721
>XP_006711681
          Length = 3448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFQVSVED 8
           ++QV VED
Sbjct: 287 IYQVKVED 294
>XP_006711680
          Length = 3617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFQVSVED 8
           ++QV VED
Sbjct: 287 IYQVKVED 294
>XP_005245637
          Length = 3683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFQVSVED 8
           ++QV VED
Sbjct: 287 IYQVKVED 294
>NP_001025024
          Length = 865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FQVSVEDT 9
           FQ++V+DT
Sbjct: 673 FQLTVKDT 680
>NP_009055
          Length = 3433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LFQVSVED 8
            L QVSV+D
Sbjct: 2783 LLQVSVDD 2790
>NP_001273615
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QVSVEDT 9
           +VS+EDT
Sbjct: 483 EVSIEDT 489
>NP_001026
          Length = 4967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2111 VSVEDT 2116
>NP_004357
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 675 FQVNTEDS 682
>NP_001164560
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 675 FQVNTEDS 682
>NP_001164559
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 631 FQVNTEDS 638
>NP_001164558
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 658 FQVNTEDS 665
>XP_005247181
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LFQVSVED 8
          +F+V+VED
Sbjct: 27 VFRVNVED 34
>XP_006713553
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 289 FQVNTEDS 296
>XP_006713552
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 675 FQVNTEDS 682
>XP_006713551
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FQVSVEDT 9
           FQV+ ED+
Sbjct: 649 FQVNTEDS 656
>XP_006711873
          Length = 4954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2110 VSVEDT 2115
>XP_006711872
          Length = 2735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>XP_006711871
          Length = 4906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>XP_006711870
          Length = 4965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>XP_006711869
          Length = 4973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>XP_006711868
          Length = 4975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2111 VSVEDT 2116
>XP_006711867
          Length = 4977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>XP_006711866
          Length = 4984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2120 VSVEDT 2125
>XP_006711865
          Length = 4985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VSVEDT 9
            VSVEDT
Sbjct: 2121 VSVEDT 2126
>NP_001862
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LFQVSVED 8
          +F+V+VED
Sbjct: 27 VFRVNVED 34
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.132    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,248
Number of extensions: 815
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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