Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055534                                                              19     665
NP_001193867                                                           19     665
NP_001193870                                                           19     665
XP_006716256                                                           19     665
XP_006716255                                                           19     665
XP_006716254                                                           19     665
XP_006716253                                                           19     665
XP_005250134                                                           19     665
XP_005250133                                                           19     665
XP_005250132                                                           19     665
XP_005250131                                                           19     665
XP_003120109                                                           19     665
NP_060417                                                              19     869
NP_001123498                                                           18    1935
XP_006715990                                                           18    1935
NP_115655                                                              17    2528
NP_940907                                                              17    2528
XP_005247886                                                           17    2528
XP_006713849                                                           17    2528
NP_065979                                                              17    4312
NP_004085                                                              17    4312
NP_001273542                                                           17    4312
NP_689594                                                              17    4312
NP_001073278                                                           17    4312
NP_073602                                                              17    4312
NP_001152763                                                           17    4312
NP_071445                                                              16    5631
NP_775179                                                              16    5631
NP_001167532                                                           16    5631
NP_003282                                                              16    5631
NP_963862                                                              16    5631
NP_963863                                                              16    5631
XP_006721306                                                           16    5631
XP_006721305                                                           16    5631
XP_005256141                                                           16    5631
XP_005268213                                                           16    5631
XP_005254130                                                           16    5631
XP_005254129                                                           16    5631
XP_005254128                                                           16    5631
XP_005254127                                                           16    5631
XP_006711741                                                           16    5631
XP_006711740                                                           16    5631
XP_005245713                                                           16    5631
XP_005245712                                                           16    5631
XP_005245710                                                           16    5631
XP_005245711                                                           16    5631
XP_006711739                                                           16    5631
XP_005245709                                                           16    5631
XP_006711738                                                           16    5631
XP_006711737                                                           16    5631
XP_005245706                                                           16    5631
XP_005245705                                                           16    5631
XP_005245704                                                           16    5631
NP_258443                                                              16    5631
YP_003024032                                                           16    5631
NP_937784                                                              16    7355
NP_891552                                                              16    7355
NP_001007564                                                           16    7355
XP_006722788                                                           16    7355
XP_005256071                                                           16    7355
XP_005256070                                                           16    7355
NP_001276046                                                           16    7355
NP_733778                                                              16    7355
NP_690872                                                              15    9605
NP_003881                                                              15    9605
NP_004827                                                              15    9605
NP_001136197                                                           15    9605
NP_542394                                                              15    9605
NP_001116118                                                           15    9605
NP_001008395                                                           15    9605
XP_006712629                                                           15    9605
XP_006712628                                                           15    9605
XP_006712627                                                           15    9605
XP_005264706                                                           15    9605
>NP_055534
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>NP_001193867
          Length = 919

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>NP_001193870
          Length = 497

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 461 FEAWAWPI 468
>XP_006716256
          Length = 919

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_006716255
          Length = 919

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_006716254
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_006716253
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_005250134
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_005250133
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_005250132
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_005250131
          Length = 921

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 885 FEAWAWPI 892
>XP_003120109
          Length = 197

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FEATAWPV 9
           FEA AWP+
Sbjct: 161 FEAWAWPI 168
>NP_060417
          Length = 888

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   FEATAWPV 9
           FE T WPV
Sbjct: 598 FEVTRWPV 605
>NP_001123498
          Length = 815

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FEATAWPV 9
           FEA  WP+
Sbjct: 781 FEAWGWPI 788
>XP_006715990
          Length = 919

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FEATAWPV 9
           FEA  WP+
Sbjct: 885 FEAWGWPI 892
>NP_115655
          Length = 1196

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LFEATAW 7
           +FEAT W
Sbjct: 552 MFEATTW 558
>NP_940907
          Length = 1218

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LFEATAW 7
           +FE TAW
Sbjct: 552 MFEGTAW 558
>XP_005247886
          Length = 1127

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LFEATAW 7
           +FEAT W
Sbjct: 552 MFEATTW 558
>XP_006713849
          Length = 1147

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LFEATAW 7
           +FEAT W
Sbjct: 503 MFEATTW 509
>NP_065979
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LFEATAWPV 9
           LF++  WP+
Sbjct: 553 LFDSRGWPL 561
>NP_004085
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LFEATAW 7
           LF+ TAW
Sbjct: 130 LFQRTAW 136
>NP_001273542
          Length = 1086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 747 EATLWP 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   EATAW 7
           EATAW
Sbjct: 586 EATAW 590
>NP_689594
          Length = 3549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LFEATAWP 8
           +FEATA P
Sbjct: 185 IFEATAGP 192
>NP_001073278
          Length = 938

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LFEATAWP 8
           +FEATA P
Sbjct: 185 IFEATAGP 192
>NP_073602
          Length = 1067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 728 EATLWP 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   EATAW 7
           EATAW
Sbjct: 567 EATAW 571
>NP_001152763
          Length = 981

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 642 EATLWP 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   EATAW 7
           EATAW
Sbjct: 481 EATAW 485
>NP_071445
          Length = 1040

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LFE   WP
Sbjct: 349 LFEHCCWP 356
>NP_775179
          Length = 1137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 980 LFEGTPW 986
>NP_001167532
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 988 LFEGTPW 994
>NP_003282
          Length = 1249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 331 EATHWP 336
>NP_963862
          Length = 1091

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 934 LFEGTPW 940
>NP_963863
          Length = 1178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 984 LFEGTPW 990
>XP_006721306
          Length = 793

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LFE   WP
Sbjct: 322 LFEHCCWP 329
>XP_006721305
          Length = 985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LFE   WP
Sbjct: 322 LFEHCCWP 329
>XP_005256141
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LFE   WP
Sbjct: 322 LFEHCCWP 329
>XP_005268213
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   EATAWP 8
           +AT+WP
Sbjct: 948 QATSWP 953
>XP_005254130
          Length = 1162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 331 EATHWP 336
>XP_005254129
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 331 EATHWP 336
>XP_005254128
          Length = 1291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 331 EATHWP 336
>XP_005254127
          Length = 1304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EATAWP 8
           EAT WP
Sbjct: 331 EATHWP 336
>XP_006711741
          Length = 1141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 984 LFEGTPW 990
>XP_006711740
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   LFEATAW 7
           LFE T W
Sbjct: 986 LFEGTPW 992
>XP_005245713
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1012 LFEGTPW 1018
>XP_005245712
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1012 LFEGTPW 1018
>XP_005245710
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1012 LFEGTPW 1018
>XP_005245711
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1012 LFEGTPW 1018
>XP_006711739
          Length = 1170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1013 LFEGTPW 1019
>XP_005245709
          Length = 1187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1030 LFEGTPW 1036
>XP_006711738
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1032 LFEGTPW 1038
>XP_006711737
          Length = 1193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1036 LFEGTPW 1042
>XP_005245706
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1059 LFEGTPW 1065
>XP_005245705
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1059 LFEGTPW 1065
>XP_005245704
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    LFEATAW 7
            LFE T W
Sbjct: 1082 LFEGTPW 1088
>NP_258443
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   FEATAWPV 9
           FE   WP+
Sbjct: 279 FETPEWPI 286
>YP_003024032
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   FEATAW 7
           FEA AW
Sbjct: 235 FEAAAW 240
>NP_937784
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 4/7 (57%)

Query: 2   FEATAWP 8
           FE   WP
Sbjct: 467 FEGVCWP 473
>NP_891552
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFEATAWP 8
           +FE TA+P
Sbjct: 431 IFEKTAFP 438
>NP_001007564
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   EATAW 7
           EATAW
Sbjct: 223 EATAW 227
>XP_006722788
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LFEATAWPV 9
           LF+   WP+
Sbjct: 125 LFDGHVWPM 133
>XP_005256071
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFEATAWP 8
           +FE TA+P
Sbjct: 200 IFEKTAFP 207
>XP_005256070
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LFEATAWP 8
           +FE TA+P
Sbjct: 345 IFEKTAFP 352
>NP_001276046
          Length = 235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LFEATAWPV 9
           LF+   WP+
Sbjct: 149 LFDGHVWPM 157
>NP_733778
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LFEATAWPV 9
           LF+   WP+
Sbjct: 144 LFDGHVWPM 152
>NP_690872
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LF+   WP
Sbjct: 211 LFQKITWP 218
>NP_003881
          Length = 5405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 2    FEATAW 7
            +EAT W
Sbjct: 1669 YEATCW 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 2    FEATAW 7
            +EAT W
Sbjct: 2870 YEATCW 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 2    FEATAW 7
            +EAT W
Sbjct: 4071 YEATCW 4076
>NP_004827
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   EATAWPV 9
           E+T WP+
Sbjct: 678 ESTDWPL 684
>NP_001136197
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 2  FEATAW 7
          FE+T W
Sbjct: 42 FESTCW 47
>NP_542394
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 2  FEATAW 7
          FE+T W
Sbjct: 42 FESTCW 47
>NP_001116118
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LF+   WP
Sbjct: 329 LFQLLTWP 336
>NP_001008395
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EATAWPV 9
           EAT+W V
Sbjct: 157 EATSWMV 163
>XP_006712629
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LF+   WP
Sbjct: 329 LFQLLTWP 336
>XP_006712628
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LF+   WP
Sbjct: 293 LFQLLTWP 300
>XP_006712627
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 1   LFEATAWP 8
           LF+   WP
Sbjct: 329 LFQLLTWP 336
>XP_005264706
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   EATAWPV 9
           E+T WP+
Sbjct: 450 ESTDWPL 456
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.134    0.505 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,300
Number of extensions: 498
Number of successful extensions: 79
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 79
Number of HSP's successfully gapped: 79
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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