Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     509
NP_671714                                                              20     509
XP_006715890                                                           20     509
XP_005250160                                                           20     509
XP_005250159                                                           20     509
NP_060921                                                              18    1935
NP_055619                                                              17    2528
XP_006721674                                                           17    2528
XP_006721673                                                           17    2528
XP_006721672                                                           17    2528
XP_005256939                                                           17    2528
XP_005256938                                                           17    2528
NP_001243415                                                           17    3301
NP_001243417                                                           17    3301
NP_004478                                                              17    3301
NP_001243416                                                           17    3301
NP_057427                                                              17    3301
XP_006713654                                                           17    3301
XP_006713653                                                           17    3301
XP_005247430                                                           17    3301
XP_005247429                                                           17    3301
XP_006713652                                                           17    3301
XP_006713651                                                           17    3301
XP_006713650                                                           17    3301
XP_005247428                                                           17    3301
NP_001073964                                                           17    4312
XP_006715861                                                           17    4312
XP_006715860                                                           17    4312
NP_000869                                                              16    5631
NP_006222                                                              16    5631
NP_001010906                                                           16    5631
NP_001157968                                                           16    5631
XP_005273560                                                           16    5631
XP_005273558                                                           16    5631
XP_005247674                                                           16    5631
XP_006713761                                                           16    5631
XP_006713760                                                           16    5631
XP_006713759                                                           16    5631
NP_065986                                                              16    7355
NP_149079                                                              16    7355
NP_001257697                                                           16    7355
XP_006726478                                                           16    7355
XP_006714496                                                           16    7355
XP_005264824                                                           16    7355
XP_005246782                                                           16    7355
XP_005246781                                                           16    7355
XP_005246780                                                           16    7355
XP_005246779                                                           16    7355
XP_005246778                                                           16    7355
XP_005246777                                                           16    7355
XP_005246776                                                           16    7355
XP_006712723                                                           16    7355
XP_006712722                                                           16    7355
XP_005246775                                                           16    7355
XP_005246419                                                           16    7355
XP_006711057                                                           16    7355
XP_006710224                                                           16    7355
NP_938012                                                              16    7355
NP_803237                                                              16    7355
NP_079452                                                              15    9605
NP_078838                                                              15    9605
XP_006723617                                                           15    9605
XP_005260737                                                           15    9605
XP_005260736                                                           15    9605
XP_006723616                                                           15    9605
XP_006723615                                                           15    9605
XP_005260735                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEVTKRDKL 9
           LEVTKR+KL
Sbjct: 945 LEVTKREKL 953
>NP_671714
          Length = 3899

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEVTKRDKL 9
           LEVTKR+KL
Sbjct: 945 LEVTKREKL 953
>XP_006715890
          Length = 3860

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEVTKRDKL 9
           LEVTKR+KL
Sbjct: 945 LEVTKREKL 953
>XP_005250160
          Length = 3939

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEVTKRDKL 9
           LEVTKR+KL
Sbjct: 945 LEVTKREKL 953
>XP_005250159
          Length = 3952

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEVTKRDKL 9
           LEVTKR+KL
Sbjct: 945 LEVTKREKL 953
>NP_060921
          Length = 1338

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LEV K+DKL
Sbjct: 1063 LEVEKKDKL 1071
>NP_055619
          Length = 967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>XP_006721674
          Length = 825

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>XP_006721673
          Length = 967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>XP_006721672
          Length = 967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>XP_005256939
          Length = 967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>XP_005256938
          Length = 967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EVTKRDKL 9
           EVTK+D+L
Sbjct: 235 EVTKKDRL 242
>NP_001243415
          Length = 3269

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 878 LEITKMDQL 886
>NP_001243417
          Length = 3184

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 798 LEITKMDQL 806
>NP_004478
          Length = 3259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 873 LEITKMDQL 881
>NP_001243416
          Length = 3225

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 839 LEITKMDQL 847
>NP_057427
          Length = 3114

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LE+TK DK+
Sbjct: 2597 LELTKMDKM 2605
>XP_006713654
          Length = 3189

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 798 LEITKMDQL 806
>XP_006713653
          Length = 3223

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 837 LEITKMDQL 845
>XP_005247430
          Length = 3228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 837 LEITKMDQL 845
>XP_005247429
          Length = 3230

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 839 LEITKMDQL 847
>XP_006713652
          Length = 3263

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 872 LEITKMDQL 880
>XP_006713651
          Length = 3264

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 873 LEITKMDQL 881
>XP_006713650
          Length = 3264

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 878 LEITKMDQL 886
>XP_005247428
          Length = 3269

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+TK D+L
Sbjct: 878 LEITKMDQL 886
>NP_001073964
          Length = 2968

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            L +TK+DKL
Sbjct: 1634 LSLTKQDKL 1642
>XP_006715861
          Length = 2189

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            L +TK+DKL
Sbjct: 1634 LSLTKQDKL 1642
>XP_006715860
          Length = 2968

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            L +TK+DKL
Sbjct: 1634 LSLTKQDKL 1642
>NP_000869
          Length = 551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LEV +RDK+
Sbjct: 325 LEVLERDKV 333
>NP_006222
          Length = 2286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           +E+T+RD L
Sbjct: 255 VEITRRDDL 263
>NP_001010906
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEVTKRDKL 9
           L VTK DKL
Sbjct: 351 LVVTKMDKL 359
>NP_001157968
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LE+ KRD++
Sbjct: 1352 LEIMKRDEI 1360
>XP_005273560
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEVTKRDKL 9
           L VTK DKL
Sbjct: 227 LVVTKMDKL 235
>XP_005273558
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEVTKRDKL 9
           L VTK DKL
Sbjct: 351 LVVTKMDKL 359
>XP_005247674
          Length = 1089

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           LE+ KRD++
Sbjct: 587 LEIMKRDEI 595
>XP_006713761
          Length = 1554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LE+ KRD++
Sbjct: 1052 LEIMKRDEI 1060
>XP_006713760
          Length = 1847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LE+ KRD++
Sbjct: 1345 LEIMKRDEI 1353
>XP_006713759
          Length = 1898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEVTKRDKL 9
            LE+ KRD++
Sbjct: 1396 LEIMKRDEI 1404
>NP_065986
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>NP_149079
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           LEVT R+K
Sbjct: 133 LEVTAREK 140
>NP_001257697
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LEVTKRDK 8
          LEVT R+K
Sbjct: 38 LEVTAREK 45
>XP_006726478
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE+TK+D
Sbjct: 127 LEITKQD 133
>XP_006714496
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE+TK+D
Sbjct: 127 LEITKQD 133
>XP_005264824
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           +E+T RD+L
Sbjct: 530 VEITPRDQL 538
>XP_005246782
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 465 LEISKRD 471
>XP_005246781
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 691 LEISKRD 697
>XP_005246780
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 691 LEISKRD 697
>XP_005246779
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_005246778
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_005246777
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_005246776
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_006712723
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_006712722
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_005246775
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE++KRD
Sbjct: 713 LEISKRD 719
>XP_005246419
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           LEV KRD+
Sbjct: 312 LEVLKRDQ 319
>XP_006711057
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           LEVT R+K
Sbjct: 134 LEVTAREK 141
>XP_006710224
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEVTKRD 7
           LE+TK+D
Sbjct: 127 LEITKQD 133
>NP_938012
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEVTKRDKL 9
           +E+T RD+L
Sbjct: 530 VEITPRDQL 538
>NP_803237
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           LEV KRD+
Sbjct: 395 LEVLKRDQ 402
>NP_079452
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEVTKRDK 8
            +EV K+DK
Sbjct: 1121 IEVLKKDK 1128
>NP_078838
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LEVTKRDKL 9
          L+VTK D L
Sbjct: 38 LQVTKHDVL 46
>XP_006723617
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           +EV K+DK
Sbjct: 501 IEVLKKDK 508
>XP_005260737
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           +EV K+DK
Sbjct: 754 IEVLKKDK 761
>XP_005260736
          Length = 1033

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           +EV K+DK
Sbjct: 772 IEVLKKDK 779
>XP_006723616
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEVTKRDK 8
           +EV K+DK
Sbjct: 962 IEVLKKDK 969
>XP_006723615
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEVTKRDK 8
            +EV K+DK
Sbjct: 1121 IEVLKKDK 1128
>XP_005260735
          Length = 1398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEVTKRDK 8
            +EV K+DK
Sbjct: 1137 IEVLKKDK 1144
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.134    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,763
Number of extensions: 815
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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