Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           18    1135
NP_000133                                                              18    1135
NP_075254                                                              18    1135
XP_006713936                                                           18    1135
XP_006713935                                                           18    1135
XP_006713934                                                           18    1135
XP_006713933                                                           18    1135
XP_006713932                                                           18    1135
XP_006713931                                                           18    1135
NP_000612                                                              16    5631
NP_001139145                                                           16    5631
XP_006714452                                                           16    5631
XP_005263364                                                           16    5631
XP_005263363                                                           16    5631
XP_005263362                                                           16    5631
XP_006714426                                                           16    5631
XP_006714423                                                           16    5631
XP_006714422                                                           16    5631
XP_006714421                                                           16    5631
XP_006714420                                                           16    5631
XP_006714419                                                           16    5631
XP_006714418                                                           16    5631
XP_006714417                                                           16    5631
XP_005263359                                                           16    5631
XP_006714416                                                           16    5631
XP_006714415                                                           16    5631
XP_006714414                                                           16    5631
XP_006714413                                                           16    5631
XP_006714412                                                           16    5631
XP_006714411                                                           16    5631
XP_006714410                                                           16    5631
XP_006714409                                                           16    5631
XP_006714408                                                           16    5631
NP_001191387                                                           16    7355
NP_001191388                                                           16    7355
NP_683760                                                              16    7355
NP_060250                                                              16    7355
NP_061117                                                              16    7355
NP_001230328                                                           16    7355
NP_932066                                                              16    7355
NP_056996                                                              16    7355
NP_057150                                                              16    7355
XP_005266502                                                           16    7355
XP_005250985                                                           16    7355
XP_006716634                                                           16    7355
XP_006716523                                                           16    7355
XP_006716522                                                           16    7355
XP_005251324                                                           16    7355
XP_005251323                                                           16    7355
XP_005245288                                                           16    7355
NP_060395                                                              15    9605
XP_006716870                                                           15    9605
XP_006716869                                                           15    9605
XP_006716868                                                           15    9605
XP_006716867                                                           15    9605
>NP_001156685
          Length = 808

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 427 LESNASMSS 435
>NP_000133
          Length = 806

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 425 LESNASMSS 433
>NP_075254
          Length = 694

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 313 LESNASMSS 321
>XP_006713936
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 425 LESNASMSS 433
>XP_006713935
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 426 LESNASMSS 434
>XP_006713934
          Length = 809

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 427 LESNASMSS 435
>XP_006713933
          Length = 810

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 428 LESNASMSS 436
>XP_006713932
          Length = 810

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 429 LESNASMSS 437
>XP_006713931
          Length = 811

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LESN SMSS
Sbjct: 429 LESNASMSS 437
>NP_000612
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ESNTSMSS 9
          E NTS+SS
Sbjct: 6  EENTSLSS 13
>NP_001139145
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ESNTSMS 8
          ESNT+MS
Sbjct: 16 ESNTTMS 22
>XP_006714452
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_005263364
          Length = 959

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_005263363
          Length = 1092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_005263362
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714426
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714423
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ESNTSMS 8
          ESNT+MS
Sbjct: 16 ESNTTMS 22
>XP_006714422
          Length = 1242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714421
          Length = 1254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714420
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ESNTSMS 8
          ESNT+MS
Sbjct: 16 ESNTTMS 22
>XP_006714419
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ESNTSMS 8
          ESNT+MS
Sbjct: 16 ESNTTMS 22
>XP_006714418
          Length = 1300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714417
          Length = 1319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_005263359
          Length = 1340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714416
          Length = 1346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 97  ESNTTMS 103
>XP_006714415
          Length = 1347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714414
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 120 ESNTTMS 126
>XP_006714413
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 120 ESNTTMS 126
>XP_006714412
          Length = 1372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714411
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 128 ESNTTMS 134
>XP_006714410
          Length = 1385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714409
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>XP_006714408
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ESNTSMS 8
           ESNT+MS
Sbjct: 151 ESNTTMS 157
>NP_001191387
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LES+TS+ S
Sbjct: 341 LESSTSLDS 349
>NP_001191388
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LES+TS+ S
Sbjct: 209 LESSTSLDS 217
>NP_683760
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LES+TS+ S
Sbjct: 341 LESSTSLDS 349
>NP_060250
          Length = 2997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ESNTSMSS 9
            ESN SMS+
Sbjct: 2271 ESNASMST 2278
>NP_061117
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LES+TS+ S
Sbjct: 341 LESSTSLDS 349
>NP_001230328
          Length = 124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LESNTSMS 8
         +ESNTS S
Sbjct: 1 MESNTSSS 8
>NP_932066
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LESNTSMS 8
          +ESNTS S
Sbjct: 41 MESNTSSS 48
>NP_056996
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESNTSMSS 9
           ESNTS+ S
Sbjct: 734 ESNTSLPS 741
>NP_057150
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LESNTSMS 8
          +ESNTS S
Sbjct: 42 MESNTSSS 49
>XP_005266502
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LESNTSMSS 9
           LES+TS+ S
Sbjct: 341 LESSTSLDS 349
>XP_005250985
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESNTSMSS 9
           ESNTS+ S
Sbjct: 734 ESNTSLPS 741
>XP_006716634
          Length = 1420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESNTSMSS 9
           ESNTS+ S
Sbjct: 748 ESNTSLPS 755
>XP_006716523
          Length = 1912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ESNTSMSS 9
            ESN SMS+
Sbjct: 1186 ESNASMST 1193
>XP_006716522
          Length = 2192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ESNTSMSS 9
            ESN SMS+
Sbjct: 1466 ESNASMST 1473
>XP_005251324
          Length = 2996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ESNTSMSS 9
            ESN SMS+
Sbjct: 2270 ESNASMST 2277
>XP_005251323
          Length = 2997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ESNTSMSS 9
            ESN SMS+
Sbjct: 2271 ESNASMST 2278
>XP_005245288
          Length = 124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LESNTSMS 8
         +ESNTS S
Sbjct: 1 MESNTSSS 8
>NP_060395
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NTSMSS 9
            NTSMSS
Sbjct: 1473 NTSMSS 1478
>XP_006716870
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NTSMSS 9
            NTSMSS
Sbjct: 1020 NTSMSS 1025
>XP_006716869
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NTSMSS 9
            NTSMSS
Sbjct: 1286 NTSMSS 1291
>XP_006716868
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NTSMSS 9
            NTSMSS
Sbjct: 1522 NTSMSS 1527
>XP_006716867
          Length = 1958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NTSMSS 9
            NTSMSS
Sbjct: 1522 NTSMSS 1527
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.272   0.0864    0.178 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 285,873
Number of extensions: 212
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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