Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_001275505                                                           17    2528
NP_001093881                                                           17    2528
NP_078857                                                              17    2528
NP_078879                                                              16    5631
NP_005427                                                              16    5631
XP_006710958                                                           16    5631
NP_071426                                                              16    5631
NP_775321                                                              16    7355
NP_001106649                                                           16    7355
NP_619728                                                              16    7355
NP_006590                                                              16    7355
NP_619727                                                              16    7355
NP_775322                                                              16    7355
NP_001269340                                                           16    7355
NP_001269343                                                           16    7355
NP_001269339                                                           16    7355
NP_001123481                                                           16    7355
NP_056052                                                              16    7355
NP_001034795                                                           16    7355
NP_001153610                                                           16    7355
NP_872431                                                              16    7355
XP_005255834                                                           16    7355
XP_006721188                                                           16    7355
XP_005250656                                                           16    7355
XP_006716193                                                           16    7355
XP_006716192                                                           16    7355
XP_005250655                                                           16    7355
XP_005250654                                                           16    7355
XP_005250653                                                           16    7355
XP_006712069                                                           16    7355
XP_006712068                                                           16    7355
XP_005262670                                                           16    7355
NP_653249                                                              16    7355
NP_001034463                                                           15    9605
NP_004716                                                              15    9605
NP_001007794                                                           15    9605
NP_443161                                                              15    9605
NP_055178                                                              15    9605
NP_001149946                                                           15    9605
NP_068599                                                              15    9605
NP_001264984                                                           15    9605
NP_004403                                                              15    9605
NP_001074319                                                           15    9605
NP_003557                                                              15    9605
NP_877435                                                              15    9605
XP_005266395                                                           15    9605
XP_006719694                                                           15    9605
XP_005274219                                                           15    9605
XP_005274218                                                           15    9605
XP_005252435                                                           15    9605
XP_005252433                                                           15    9605
XP_005252432                                                           15    9605
XP_005252431                                                           15    9605
XP_005252430                                                           15    9605
XP_005252429                                                           15    9605
XP_006717451                                                           15    9605
XP_006710380                                                           15    9605
XP_005245788                                                           15    9605
XP_006710379                                                           15    9605
XP_006710378                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LENNIQQKQ 9
            LE NIQQKQ
Sbjct: 3122 LEYNIQQKQ 3130
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LENNIQQKQ 9
            LE NIQQKQ
Sbjct: 3114 LEYNIQQKQ 3122
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LENNIQQKQ 9
            LE NIQQKQ
Sbjct: 3075 LEYNIQQKQ 3083
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LENNIQQKQ 9
            LE NIQQKQ
Sbjct: 3154 LEYNIQQKQ 3162
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LENNIQQKQ 9
            LE NIQQKQ
Sbjct: 3167 LEYNIQQKQ 3175
>NP_001275505
          Length = 936

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           LEN++QQK
Sbjct: 649 LENHLQQK 656
>NP_001093881
          Length = 971

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           LEN++QQK
Sbjct: 649 LENHLQQK 656
>NP_078857
          Length = 1140

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           LEN++QQK
Sbjct: 769 LENHLQQK 776
>NP_078879
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LENNIQQKQ 9
          LEN++ QK+
Sbjct: 81 LENSVMQKK 89
>NP_005427
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LENNIQQKQ 9
           LEN ++Q+Q
Sbjct: 202 LENTLEQEQ 210
>XP_006710958
          Length = 367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LENNIQQKQ 9
          LEN++ QK+
Sbjct: 27 LENSVMQKK 35
>NP_071426
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LENNIQQKQ 9
          +ENNIQ  Q
Sbjct: 83 MENNIQMIQ 91
>NP_775321
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 695 LQNTIQQLQ 703
>NP_001106649
          Length = 1548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 788 LQNTIQQLQ 796
>NP_619728
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 695 LQNTIQQLQ 703
>NP_006590
          Length = 1531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 771 LQNTIQQLQ 779
>NP_619727
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 789 LQNTIQQLQ 797
>NP_775322
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 695 LQNTIQQLQ 703
>NP_001269340
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LENNIQ 6
           LENN+Q
Sbjct: 227 LENNVQ 232
>NP_001269343
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LENNIQ 6
           LENN+Q
Sbjct: 211 LENNVQ 216
>NP_001269339
          Length = 280

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LENNIQ 6
           LENN+Q
Sbjct: 270 LENNVQ 275
>NP_001123481
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           +ENNI++K
Sbjct: 312 VENNIKKK 319
>NP_056052
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LENNIQQK 8
            +EN+IQQ+
Sbjct: 1124 VENDIQQR 1131
>NP_001034795
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 546 ENHIQRKE 553
>NP_001153610
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 528 ENHIQRKE 535
>NP_872431
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           +ENNI++K
Sbjct: 312 VENNIKKK 319
>XP_005255834
          Length = 1264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 504 LQNTIQQLQ 512
>XP_006721188
          Length = 1484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LENNIQQKQ 9
           L+N IQQ Q
Sbjct: 724 LQNTIQQLQ 732
>XP_005250656
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 546 ENHIQRKE 553
>XP_006716193
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 357 ENHIQRKE 364
>XP_006716192
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 399 ENHIQRKE 406
>XP_005250655
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 546 ENHIQRKE 553
>XP_005250654
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 546 ENHIQRKE 553
>XP_005250653
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ENNIQQKQ 9
           EN+IQ+K+
Sbjct: 546 ENHIQRKE 553
>XP_006712069
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           +ENNI++K
Sbjct: 312 VENNIKKK 319
>XP_006712068
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           +ENNI++K
Sbjct: 312 VENNIKKK 319
>XP_005262670
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LENNIQQK 8
           +ENNI++K
Sbjct: 312 VENNIKKK 319
>NP_653249
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           LEN IQ+K
Sbjct: 335 LENPIQEK 342
>NP_001034463
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LENNIQQ 7
           LENNI++
Sbjct: 151 LENNIEK 157
>NP_004716
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENNIQQ 7
           ENNI+Q
Sbjct: 228 ENNIEQ 233
>NP_001007794
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENNIQQ 7
           ENNI+Q
Sbjct: 228 ENNIEQ 233
>NP_443161
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LENNIQQ 7
            +ENN+Q+
Sbjct: 1188 MENNVQK 1194
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LENNIQQK 8
            LEN +QQK
Sbjct: 4571 LENFMQQK 4578
>NP_001149946
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENNIQQKQ 9
           EN I+Q+Q
Sbjct: 441 ENEIKQRQ 448
>NP_068599
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENNIQQKQ 9
           EN I+Q+Q
Sbjct: 351 ENEIKQRQ 358
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LENNIQQK 8
            LEN +QQK
Sbjct: 4424 LENFMQQK 4431
>NP_004403
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 201 VENKIQEK 208
>NP_001074319
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   ENNIQQK 8
           +NN+Q+K
Sbjct: 335 QNNLQEK 341
>NP_003557
          Length = 1411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           LEN +QQ+
Sbjct: 992 LENKLQQQ 999
>NP_877435
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NNIQQKQ 9
           N+IQ+KQ
Sbjct: 194 NSIQEKQ 200
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LENNIQQK 8
            LEN +QQK
Sbjct: 4580 LENFMQQK 4587
>XP_006719694
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LENNIQQK 8
            LEN +QQ+
Sbjct: 1046 LENKLQQQ 1053
>XP_005274219
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENNIQQKQ 9
           EN I+Q+Q
Sbjct: 152 ENEIKQRQ 159
>XP_005274218
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENNIQQKQ 9
           EN I+Q+Q
Sbjct: 393 ENEIKQRQ 400
>XP_005252435
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 130 VENKIQEK 137
>XP_005252433
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 130 VENKIQEK 137
>XP_005252432
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 155 VENKIQEK 162
>XP_005252431
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 201 VENKIQEK 208
>XP_005252430
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 173 VENKIQEK 180
>XP_005252429
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 201 VENKIQEK 208
>XP_006717451
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LENNIQQK 8
           +EN IQ+K
Sbjct: 201 VENKIQEK 208
>XP_006710380
          Length = 1398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LENNIQQ 7
            +ENN+Q+
Sbjct: 1174 MENNVQK 1180
>XP_005245788
          Length = 1434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LENNIQQ 7
            +ENN+Q+
Sbjct: 1210 MENNVQK 1216
>XP_006710379
          Length = 1452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LENNIQQ 7
            +ENN+Q+
Sbjct: 1210 MENNVQK 1216
>XP_006710378
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LENNIQQ 7
            +ENN+Q+
Sbjct: 1209 MENNVQK 1215
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.118    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 624,200
Number of extensions: 1635
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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