Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001103467                                                           17    4312
XP_005267404                                                           17    4312
NP_003792                                                              17    4312
NP_005518                                                              16    5631
NP_005337                                                              16    5631
NP_071324                                                              16    5631
NP_005336                                                              16    5631
NP_002146                                                              16    5631
NP_078928                                                              16    5631
XP_005275459                                                           16    5631
XP_005275458                                                           16    5631
XP_005275456                                                           16    5631
XP_005275031                                                           16    5631
XP_005275030                                                           16    5631
XP_005275027                                                           16    5631
XP_005272874                                                           16    5631
XP_005272873                                                           16    5631
XP_005272870                                                           16    5631
XP_005274919                                                           16    5631
XP_005274918                                                           16    5631
XP_005274916                                                           16    5631
XP_005255036                                                           16    5631
XP_005249128                                                           16    5631
XP_005249130                                                           16    5631
XP_005249127                                                           16    5631
NP_004624                                                              16    7355
NP_796375                                                              16    7355
XP_005259729                                                           16    7355
XP_005259728                                                           16    7355
XP_006712799                                                           16    7355
XP_006712798                                                           16    7355
XP_006712797                                                           16    7355
XP_006712796                                                           16    7355
NP_001128129                                                           16    7355
NP_001230526                                                           15    9605
NP_058648                                                              15    9605
NP_001245221                                                           15    9605
NP_036472                                                              15    9605
NP_001129493                                                           15    9605
NP_001245226                                                           15    9605
NP_775114                                                              15    9605
NP_001245223                                                           15    9605
NP_001245225                                                           15    9605
NP_001245224                                                           15    9605
XP_006726566                                                           15    9605
XP_005260470                                                           15    9605
XP_006717411                                                           15    9605
XP_001716413                                                           15    9605
XP_006710279                                                           15    9605
>NP_001103467
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   EMAPLSLA 9
           EMAPLS A
Sbjct: 304 EMAPLSQA 311
>XP_005267404
          Length = 797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   EMAPLSLA 9
           EMAPLS A
Sbjct: 568 EMAPLSQA 575
>NP_003792
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LEMAPLSLA 9
           L+ APLSLA
Sbjct: 567 LQEAPLSLA 575
>NP_005518
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>NP_005337
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 394 LDVAPLSL 401
>NP_071324
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           +E+APLS+
Sbjct: 307 IELAPLSM 314
>NP_005336
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 394 LDVAPLSL 401
>NP_002146
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>NP_078928
          Length = 2015

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEMAPLS 7
            LE+APLS
Sbjct: 1334 LELAPLS 1340
>XP_005275459
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005275458
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005275456
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 460 LDVAPLSL 467
>XP_005275031
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005275030
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005275027
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 460 LDVAPLSL 467
>XP_005272874
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005272873
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005272870
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 460 LDVAPLSL 467
>XP_005274919
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005274918
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005274916
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 460 LDVAPLSL 467
>XP_005255036
          Length = 1310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LEMAPLS 7
           LE+APLS
Sbjct: 629 LELAPLS 635
>XP_005249128
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005249130
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 396 LDVAPLSL 403
>XP_005249127
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           L++APLSL
Sbjct: 460 LDVAPLSL 467
>NP_004624
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MAPLSLA 9
           +APLSLA
Sbjct: 354 LAPLSLA 360
>NP_796375
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EMAPLSLA 9
          E AP+SLA
Sbjct: 27 EAAPMSLA 34
>XP_005259729
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EMAPLSLA 9
          E AP+SLA
Sbjct: 27 EAAPMSLA 34
>XP_005259728
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EMAPLSLA 9
          E AP+SLA
Sbjct: 27 EAAPMSLA 34
>XP_006712799
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MAPLSLA 9
           +APLSLA
Sbjct: 379 LAPLSLA 385
>XP_006712798
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MAPLSLA 9
           +APLSLA
Sbjct: 269 LAPLSLA 275
>XP_006712797
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MAPLSLA 9
           +APLSLA
Sbjct: 354 LAPLSLA 360
>XP_006712796
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MAPLSLA 9
           +APLSLA
Sbjct: 358 LAPLSLA 364
>NP_001128129
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LEMAPLSL 8
          LE+AP+S+
Sbjct: 80 LELAPMSV 87
>NP_001230526
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LEMAPLS 7
            LEM PLS
Sbjct: 1147 LEMKPLS 1153
>NP_058648
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LEMAPLS 7
            LEM PLS
Sbjct: 1147 LEMKPLS 1153
>NP_001245221
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 750 LMAAPLSLA 758
>NP_036472
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 770 LMAAPLSLA 778
>NP_001129493
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 750 LMAAPLSLA 758
>NP_001245226
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 551 LMAAPLSLA 559
>NP_775114
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 770 LMAAPLSLA 778
>NP_001245223
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 551 LMAAPLSLA 559
>NP_001245225
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 551 LMAAPLSLA 559
>NP_001245224
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 551 LMAAPLSLA 559
>XP_006726566
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           +EMAPL  A
Sbjct: 419 MEMAPLGPA 427
>XP_005260470
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           L  APLSLA
Sbjct: 769 LMAAPLSLA 777
>XP_006717411
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           +EMAPL  A
Sbjct: 419 MEMAPLGPA 427
>XP_001716413
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LEMAPLSL 8
           +E+APL+L
Sbjct: 496 VELAPLTL 503
>XP_006710279
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEMAPLSLA 9
           +EMAPL  A
Sbjct: 419 MEMAPLGPA 427
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.128    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 517,401
Number of extensions: 545
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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