Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
NP_112552                                                              17    3301
NP_112553                                                              17    3301
NP_002131                                                              17    3301
XP_005252023                                                           17    3301
XP_005252022                                                           17    3301
XP_005252020                                                           17    3301
XP_005252021                                                           17    3301
XP_005252018                                                           17    3301
XP_005252017                                                           17    3301
NP_001036068                                                           17    4312
NP_055990                                                              17    4312
NP_001140177                                                           17    4312
NP_004644                                                              17    4312
NP_001140178                                                           17    4312
XP_005262619                                                           17    4312
XP_005262618                                                           17    4312
XP_005262617                                                           17    4312
XP_005265049                                                           17    4312
XP_006713135                                                           17    4312
NP_004435                                                              15    9605
NP_940953                                                              15    9605
XP_005273179                                                           15    9605
XP_006711367                                                           15    9605
XP_005273178                                                           15    9605
NP_006062                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELRVLLES 9
            LEL+VLLES
Sbjct: 3296 LELQVLLES 3304
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELRVLLES 9
            LEL+VLLES
Sbjct: 3288 LELQVLLES 3296
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELRVLLES 9
            LEL+VLLES
Sbjct: 3249 LELQVLLES 3257
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELRVLLES 9
            LEL+VLLES
Sbjct: 3328 LELQVLLES 3336
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELRVLLES 9
            LEL+VLLES
Sbjct: 3341 LELQVLLES 3349
>NP_112552
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>NP_112553
          Length = 464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>NP_002131
          Length = 464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252023
          Length = 439

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252022
          Length = 440

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252020
          Length = 440

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252021
          Length = 440

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252018
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>XP_005252017
          Length = 464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LELRVLLES 9
          +ELR+LL+S
Sbjct: 43 VELRILLQS 51
>NP_001036068
          Length = 1690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LELRVLLE 8
           +ELRV+LE
Sbjct: 761 IELRVMLE 768
>NP_055990
          Length = 2754

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ELRVLLES 9
           ELR LLES
Sbjct: 272 ELRALLES 279
>NP_001140177
          Length = 1570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 870 ELRVLLE 876
>NP_004644
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 839 ELRVLLE 845
>NP_001140178
          Length = 1482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 782 ELRVLLE 788
>XP_005262619
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 839 ELRVLLE 845
>XP_005262618
          Length = 1462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 839 ELRVLLE 845
>XP_005262617
          Length = 1494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ELRVLLE 8
           ELRVLLE
Sbjct: 794 ELRVLLE 800
>XP_005265049
          Length = 2720

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ELRVLLES 9
           ELR LLES
Sbjct: 265 ELRALLES 272
>XP_006713135
          Length = 2727

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ELRVLLES 9
           ELR LLES
Sbjct: 272 ELRALLES 279
>NP_004435
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 LELRVLL 7
         +ELRVLL
Sbjct: 1 MELRVLL 7
>NP_940953
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LRVLLES 9
            LRV+LES
Sbjct: 1286 LRVMLES 1292
>XP_005273179
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LRVLLES 9
           LRV+LES
Sbjct: 164 LRVMLES 170
>XP_006711367
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LRVLLES 9
            LRV+LES
Sbjct: 1286 LRVMLES 1292
>XP_005273178
          Length = 1931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LRVLLES 9
            LRV+LES
Sbjct: 1286 LRVMLES 1292
>NP_006062
          Length = 2253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LELRVLLES 9
          L+LRVLL +
Sbjct: 91 LDLRVLLSA 99
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.145    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 377,551
Number of extensions: 903
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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