Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000775                                                              18    1482
NP_000042                                                              18    1482
XP_006718908                                                           18    1482
XP_005271621                                                           18    1482
XP_006718907                                                           18    1482
XP_006718906                                                           18    1482
XP_005271619                                                           18    1482
XP_005271618                                                           18    1482
NP_112586                                                              18    1482
NP_037506                                                              17    2528
NP_001155901                                                           17    2528
NP_775886                                                              17    3301
XP_006726674                                                           17    3301
XP_006721084                                                           17    3301
NP_001073910                                                           17    4312
XP_006726595                                                           16    5631
XP_005274478                                                           16    5631
XP_005274477                                                           16    5631
XP_005274475                                                           16    5631
NP_061869                                                              16    7355
NP_001136112                                                           16    7355
NP_065816                                                              16    7355
NP_001186702                                                           16    7355
NP_001186703                                                           16    7355
NP_002781                                                              16    7355
NP_001186701                                                           16    7355
NP_055690                                                              16    7355
NP_001273336                                                           16    7355
NP_689473                                                              16    7355
NP_001177719                                                           16    7355
XP_006722063                                                           16    7355
XP_006722062                                                           16    7355
XP_006722061                                                           16    7355
XP_006722060                                                           16    7355
XP_005257605                                                           16    7355
XP_005257604                                                           16    7355
XP_006722059                                                           16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_004111                                                              15    9605
NP_009049                                                              15    9605
NP_056448                                                              15    9605
NP_001165358                                                           15    9605
NP_055635                                                              15    9605
NP_061330                                                              15    9605
NP_061325                                                              15    9605
NP_940998                                                              15    9605
NP_001155313                                                           15    9605
NP_001243758                                                           15    9605
XP_006723893                                                           15    9605
XP_005260515                                                           15    9605
XP_006723892                                                           15    9605
XP_006723891                                                           15    9605
XP_006723890                                                           15    9605
XP_006714558                                                           15    9605
>NP_000775
          Length = 531

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEKAVEVDG 9
           +EK +EVDG
Sbjct: 407 IEKEIEVDG 415
>NP_000042
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2361 LEKAVEVAG 2369
>XP_006718908
          Length = 1708

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 1013 LEKAVEVAG 1021
>XP_005271621
          Length = 2708

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2013 LEKAVEVAG 2021
>XP_006718907
          Length = 3050

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2355 LEKAVEVAG 2363
>XP_006718906
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2361 LEKAVEVAG 2369
>XP_005271619
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2361 LEKAVEVAG 2369
>XP_005271618
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LEKAVEVDG 9
            LEKAVEV G
Sbjct: 2361 LEKAVEVAG 2369
>NP_112586
          Length = 229

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  EKAVEVDG 9
          E+AVE+DG
Sbjct: 72 ERAVEIDG 79
>NP_037506
          Length = 868

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEKAVEVDG 9
           L+KAV+ DG
Sbjct: 499 LDKAVQADG 507
>NP_001155901
          Length = 873

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEKAVEVDG 9
           L+KAV+ DG
Sbjct: 504 LDKAVQADG 512
>NP_775886
          Length = 1184

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           L KAVEVD
Sbjct: 593 LRKAVEVD 600
>XP_006726674
          Length = 1205

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           L KAVEVD
Sbjct: 614 LRKAVEVD 621
>XP_006721084
          Length = 1205

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           L KAVEVD
Sbjct: 614 LRKAVEVD 621
>NP_001073910
          Length = 189

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEKAVEVDG 9
           LE+AVE+ G
Sbjct: 108 LERAVELSG 116
>XP_006726595
          Length = 526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEKAVEVDG 9
           +EK VEV G
Sbjct: 454 IEKVVEVTG 462
>XP_005274478
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEKAVEVDG 9
           +EK VEV G
Sbjct: 419 IEKVVEVTG 427
>XP_005274477
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEKAVEVDG 9
           +EK VEV G
Sbjct: 440 IEKVVEVTG 448
>XP_005274475
          Length = 526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEKAVEVDG 9
           +EK VEV G
Sbjct: 454 IEKVVEVTG 462
>NP_061869
          Length = 1690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           LEK V+VD
Sbjct: 976 LEKKVDVD 983
>NP_001136112
          Length = 1726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           LEK V+VD
Sbjct: 973 LEKKVDVD 980
>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>NP_001186702
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LEKAVEVD 8
          +EK VE+D
Sbjct: 6  IEKIVEID 13
>NP_001186703
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LEKAVEVD 8
          +EK VE+D
Sbjct: 6  IEKIVEID 13
>NP_002781
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LEKAVEVD 8
          +EK VE+D
Sbjct: 64 IEKIVEID 71
>NP_001186701
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LEKAVEVD 8
          +EK VE+D
Sbjct: 6  IEKIVEID 13
>NP_055690
          Length = 1648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LEKAVEV 7
            LEKA+E+
Sbjct: 1510 LEKAIEI 1516
>NP_001273336
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EKAVEVD 8
           EKAVE D
Sbjct: 422 EKAVETD 428
>NP_689473
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EKAVEVD 8
           EKAVE D
Sbjct: 483 EKAVETD 489
>NP_001177719
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKAVEVDG 9
           E+A+EV+G
Sbjct: 116 ERALEVEG 123
>XP_006722063
          Length = 1923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1209 LEKKVDVD 1216
>XP_006722062
          Length = 1866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1212 LEKKVDVD 1219
>XP_006722061
          Length = 1913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1212 LEKKVDVD 1219
>XP_006722060
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1212 LEKKVDVD 1219
>XP_005257605
          Length = 1926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1212 LEKKVDVD 1219
>XP_005257604
          Length = 1962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1209 LEKKVDVD 1216
>XP_006722059
          Length = 1965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEKAVEVD 8
            LEK V+VD
Sbjct: 1212 LEKKVDVD 1219
>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKAVEVD 8
            E+A+EVD
Sbjct: 1627 ERAIEVD 1633
>NP_004111
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EKAVEVD 8
           EKA+EV+
Sbjct: 484 EKAIEVE 490
>NP_009049
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEKAVEV 7
            LE+AVEV
Sbjct: 2128 LERAVEV 2134
>NP_056448
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           + KA+E+D
Sbjct: 186 MRKAIEID 193
>NP_001165358
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           + KA+E+D
Sbjct: 148 MRKAIEID 155
>NP_055635
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           + KA+E+D
Sbjct: 534 ISKAIEID 541
>NP_061330
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEKAVEVD 8
           LEK +E+D
Sbjct: 104 LEKKIELD 111
>NP_061325
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>NP_940998
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>NP_001155313
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>NP_001243758
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EKAVEVDG 9
          EKAVE+ G
Sbjct: 5  EKAVEILG 12
>XP_006723893
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>XP_005260515
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>XP_006723892
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>XP_006723891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>XP_006723890
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVEVDG 9
           A+EVDG
Sbjct: 541 AIEVDG 546
>XP_006714558
          Length = 2612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEKAVEV 7
            LE+AVEV
Sbjct: 1643 LERAVEV 1649
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.132    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 443,093
Number of extensions: 1919
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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