Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_057287                                                              17    4312
NP_077747                                                              17    4312
NP_001035723                                                           17    4312
XP_005250066                                                           17    4312
XP_005250064                                                           17    4312
XP_005250063                                                           17    4312
XP_005250062                                                           17    4312
XP_005250061                                                           17    4312
XP_006716084                                                           17    4312
XP_005250060                                                           17    4312
XP_005250059                                                           17    4312
NP_001001323                                                           16    5631
NP_001673                                                              16    5631
NP_065813                                                              16    5631
NP_114432                                                              16    5631
NP_006382                                                              16    5631
NP_064562                                                              16    5631
XP_005269099                                                           16    5631
XP_005268976                                                           16    5631
XP_005272092                                                           16    5631
NP_001121649                                                           16    7355
NP_001121648                                                           16    7355
NP_000452                                                              16    7355
NP_001239563                                                           16    7355
NP_853517                                                              16    7355
NP_853515                                                              16    7355
NP_055665                                                              16    7355
NP_001093900                                                           16    7355
NP_001028289                                                           16    7355
NP_001693                                                              16    7355
XP_005257400                                                           16    7355
XP_006721927                                                           16    7355
XP_005257364                                                           16    7355
XP_005251072                                                           16    7355
XP_006714348                                                           16    7355
XP_006714347                                                           16    7355
XP_006713496                                                           16    7355
XP_005265679                                                           16    7355
XP_005265482                                                           16    7355
XP_005265481                                                           16    7355
XP_005265480                                                           16    7355
XP_006713381                                                           16    7355
XP_005265478                                                           16    7355
XP_006713380                                                           16    7355
XP_005265477                                                           16    7355
NP_001093896                                                           16    7355
NP_001093898                                                           16    7355
NP_066982                                                              16    7355
NP_001093897                                                           16    7355
NP_001093899                                                           16    7355
NP_056141                                                              15    9605
NP_001164108                                                           15    9605
NP_079467                                                              15    9605
NP_775922                                                              15    9605
XP_005245556                                                           15    9605
XP_005277572                                                           15    9605
XP_005277571                                                           15    9605
XP_006711310                                                           15    9605
XP_005277570                                                           15    9605
XP_005277569                                                           15    9605
XP_006711309                                                           15    9605
XP_005277568                                                           15    9605
XP_005277567                                                           15    9605
NP_149974                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LEIIKTIVE 9
            LEIIKT+VE
Sbjct: 2235 LEIIKTLVE 2243
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LEIIKTIVE 9
            LEIIKT+VE
Sbjct: 2235 LEIIKTLVE 2243
>NP_057287
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 514 LEILETIVD 522
>NP_077747
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 273 LEILETIVD 281
>NP_001035723
          Length = 525

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 470 LEILETIVD 478
>XP_005250066
          Length = 358

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 253 LEILETIVD 261
>XP_005250064
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 389 LEILETIVD 397
>XP_005250063
          Length = 495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 390 LEILETIVD 398
>XP_005250062
          Length = 568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 513 LEILETIVD 521
>XP_005250061
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 470 LEILETIVD 478
>XP_006716084
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 510 LEILETIVD 518
>XP_005250060
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 513 LEILETIVD 521
>XP_005250059
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LEIIKTIVE 9
           LEI++TIV+
Sbjct: 514 LEILETIVD 522
>NP_001001323
          Length = 1176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           +I+KT++E
Sbjct: 631 DIVKTVIE 638
>NP_001673
          Length = 1220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           +I+KT++E
Sbjct: 631 DIVKTVIE 638
>NP_065813
          Length = 1085

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           EIIKTI+
Sbjct: 681 EIIKTII 687
>NP_114432
          Length = 1249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LEIIKTIV 8
           LE++KT++
Sbjct: 717 LELVKTVI 724
>NP_006382
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LEIIKTIV 8
           +EI+KT+V
Sbjct: 229 IEILKTVV 236
>NP_064562
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEIIKTIVE 9
           LEI+K +VE
Sbjct: 129 LEIVKYLVE 137
>XP_005269099
          Length = 1062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           EIIKTI+
Sbjct: 658 EIIKTII 664
>XP_005268976
          Length = 1249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           +I+KT++E
Sbjct: 631 DIVKTVIE 638
>XP_005272092
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEIIKTIVE 9
           LEI+K +VE
Sbjct: 129 LEIVKYLVE 137
>NP_001121649
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>NP_001121648
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>NP_000452
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>NP_001239563
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>NP_853517
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           I+KT+VE
Sbjct: 425 IVKTVVE 431
>NP_853515
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           I+KT+VE
Sbjct: 420 IVKTVVE 426
>NP_055665
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 681 EVIKTII 687
>NP_001093900
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 390 DVIKTIVQ 397
>NP_001028289
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 657 EVIKTII 663
>NP_001693
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           E+I+T+VE
Sbjct: 664 EVIQTLVE 671
>XP_005257400
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           +IKTI+E
Sbjct: 596 VIKTIIE 602
>XP_006721927
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           I+KT+VE
Sbjct: 422 IVKTVVE 428
>XP_005257364
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           I+KT+VE
Sbjct: 423 IVKTVVE 429
>XP_005251072
          Length = 1586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           E+I+T+VE
Sbjct: 661 EVIQTLVE 668
>XP_006714348
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 352 DVIKTIVQ 359
>XP_006714347
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 401 DVIKTIVQ 408
>XP_006713496
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 173 EVIKTII 179
>XP_005265679
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 681 EVIKTII 687
>XP_005265482
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_005265481
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_005265480
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_006713381
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_005265478
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_006713380
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 220 ELIKTVTE 227
>XP_005265477
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIIKTIVE 9
           E+IKT+ E
Sbjct: 235 ELIKTVTE 242
>NP_001093896
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 482 DVIKTIVQ 489
>NP_001093898
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 433 DVIKTIVQ 440
>NP_066982
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 481 DVIKTIVQ 488
>NP_001093897
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 481 DVIKTIVQ 488
>NP_001093899
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EIIKTIVE 9
           ++IKTIV+
Sbjct: 432 DVIKTIVQ 439
>NP_056141
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 666 ELIKTII 672
>NP_001164108
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 665 ELIKTII 671
>NP_079467
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIIKTIVE 9
           LE+ KT++E
Sbjct: 423 LEVGKTLIE 431
>NP_775922
          Length = 6996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    EIIKTIVE 9
            +++KTIV+
Sbjct: 4781 DVVKTIVD 4788
>XP_005245556
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIIKTIVE 9
           LE+ KT++E
Sbjct: 423 LEVGKTLIE 431
>XP_005277572
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 665 ELIKTII 671
>XP_005277571
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_006711310
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_005277570
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 513 ELIKTII 519
>XP_005277569
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 513 ELIKTII 519
>XP_006711309
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_005277568
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 665 ELIKTII 671
>XP_005277567
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EIIKTIV 8
           E+IKTI+
Sbjct: 666 ELIKTII 672
>NP_149974
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IIKTIVE 9
           ++KTIVE
Sbjct: 124 LVKTIVE 130
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.147    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 361,705
Number of extensions: 581
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package