Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_001273988                                                           17    3301
NP_055867                                                              17    3301
NP_001036167                                                           17    3301
NP_065811                                                              17    3301
XP_006715736                                                           17    3301
XP_006715735                                                           17    3301
XP_005249722                                                           17    3301
XP_006715734                                                           17    3301
XP_006715733                                                           17    3301
XP_006712712                                                           17    3301
XP_006712711                                                           17    3301
XP_006712710                                                           17    3301
XP_006712709                                                           17    3301
XP_005246686                                                           17    3301
XP_006712617                                                           17    3301
XP_005246684                                                           17    3301
XP_005246683                                                           17    3301
NP_003794                                                              17    4312
NP_062830                                                              17    4312
NP_001008844                                                           16    7355
NP_004406                                                              16    7355
NP_005777                                                              16    7355
NP_001244963                                                           16    7355
NP_001244965                                                           16    7355
NP_060589                                                              16    7355
NP_001244964                                                           16    7355
NP_001244962                                                           16    7355
XP_006726676                                                           16    7355
XP_005276555                                                           16    7355
XP_005266698                                                           16    7355
XP_005266697                                                           16    7355
XP_006721126                                                           16    7355
NP_115266                                                              16    7355
NP_061745                                                              16    7355
NP_001629                                                              15    9605
NP_055816                                                              15    9605
NP_001123910                                                           15    9605
NP_003118                                                              15    9605
NP_110439                                                              15    9605
NP_055244                                                              15    9605
NP_001182461                                                           15    9605
NP_001073944                                                           15    9605
NP_060899                                                              15    9605
NP_060883                                                              15    9605
XP_006725524                                                           15    9605
XP_006725523                                                           15    9605
XP_005276828                                                           15    9605
XP_006726279                                                           15    9605
XP_006717317                                                           15    9605
XP_006717316                                                           15    9605
XP_006717315                                                           15    9605
XP_006717314                                                           15    9605
XP_006717312                                                           15    9605
XP_006717311                                                           15    9605
XP_006717310                                                           15    9605
XP_006717309                                                           15    9605
XP_006717308                                                           15    9605
XP_006714722                                                           15    9605
XP_006714721                                                           15    9605
XP_005247419                                                           15    9605
XP_005246602                                                           15    9605
XP_006712584                                                           15    9605
XP_005246601                                                           15    9605
XP_005246600                                                           15    9605
NP_001167453                                                           15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LEETSTYAL 9
            +EETSTYAL
Sbjct: 1177 VEETSTYAL 1185
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LEETSTYAL 9
           +EETSTYAL
Sbjct: 972 VEETSTYAL 980
>NP_001273988
          Length = 1572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1563 VEETSTFGL 1571
>NP_055867
          Length = 1606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1597 VEETSTFGL 1605
>NP_001036167
          Length = 352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EETSTYAL 9
           EET+T+AL
Sbjct: 237 EETATFAL 244
>NP_065811
          Length = 1572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1563 VEETSTFGL 1571
>XP_006715736
          Length = 1573

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1564 VEETSTFGL 1572
>XP_006715735
          Length = 1606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1597 VEETSTFGL 1605
>XP_005249722
          Length = 1607

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1598 VEETSTFGL 1606
>XP_006715734
          Length = 1607

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1598 VEETSTFGL 1606
>XP_006715733
          Length = 1608

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1599 VEETSTFGL 1607
>XP_006712712
          Length = 1414

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1405 VEETSTFGL 1413
>XP_006712711
          Length = 1448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1439 VEETSTFGL 1447
>XP_006712710
          Length = 1528

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1519 VEETSTFGL 1527
>XP_006712709
          Length = 1579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEETSTYAL 9
            +EETST+ L
Sbjct: 1570 VEETSTFGL 1578
>XP_005246686
          Length = 349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EETSTYAL 9
           EET+T+AL
Sbjct: 234 EETATFAL 241
>XP_006712617
          Length = 352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EETSTYAL 9
           EET+T+AL
Sbjct: 237 EETATFAL 244
>XP_005246684
          Length = 355

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EETSTYAL 9
           EET+T+AL
Sbjct: 240 EETATFAL 247
>XP_005246683
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EETSTYAL 9
           EET+T+AL
Sbjct: 272 EETATFAL 279
>NP_003794
          Length = 1685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LEETSTY 7
           LEET TY
Sbjct: 258 LEETETY 264
>NP_062830
          Length = 1589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LEETSTY 7
           LEET TY
Sbjct: 258 LEETETY 264
>NP_001008844
          Length = 2272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LEETSTYA 8
            L++TS+YA
Sbjct: 2165 LQDTSSYA 2172
>NP_004406
          Length = 2871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LEETSTYA 8
            L++TS+YA
Sbjct: 2764 LQDTSSYA 2771
>NP_005777
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEETSTYAL 9
           L++TS+Y L
Sbjct: 163 LQQTSSYGL 171
>NP_001244963
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 51 DETSTYS 57
>NP_001244965
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>NP_060589
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>NP_001244964
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 51 DETSTYS 57
>NP_001244962
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>XP_006726676
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>XP_005276555
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>XP_005266698
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEETSTYAL 9
           L++TS+Y L
Sbjct: 163 LQQTSSYGL 171
>XP_005266697
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEETSTYAL 9
           L++TS+Y L
Sbjct: 208 LQQTSSYGL 216
>XP_006721126
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EETSTYA 8
          +ETSTY+
Sbjct: 87 DETSTYS 93
>NP_115266
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EETSTYAL 9
           EETS Y L
Sbjct: 306 EETSRYVL 313
>NP_061745
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EETSTYAL 9
           EETS Y L
Sbjct: 306 EETSRYVL 313
>NP_001629
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEETSTYA 8
           LEET+T A
Sbjct: 287 LEETTTLA 294
>NP_055816
          Length = 3664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           LE+T+TY
Sbjct: 445 LEKTTTY 451
>NP_001123910
          Length = 2477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2226 IQETRTYLL 2234
>NP_003118
          Length = 2472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2221 IQETRTYLL 2229
>NP_110439
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEETSTYAL 9
           L+E++TY L
Sbjct: 232 LDESNTYQL 240
>NP_055244
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LEETSTY 7
           LE+T TY
Sbjct: 940 LEQTDTY 946
>NP_001182461
          Length = 2452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2201 IQETRTYLL 2209
>NP_001073944
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           L+ETST+
Sbjct: 137 LDETSTF 143
>NP_060899
          Length = 2624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>NP_060883
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LEETSTYAL 9
           LEE S Y L
Sbjct: 282 LEEDSNYVL 290
>XP_006725524
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_006725523
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_005276828
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_006726279
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_006717317
          Length = 2498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2226 IQETRTYLL 2234
>XP_006717316
          Length = 2464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2213 IQETRTYLL 2221
>XP_006717315
          Length = 2469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2218 IQETRTYLL 2226
>XP_006717314
          Length = 2478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2206 IQETRTYLL 2214
>XP_006717312
          Length = 2484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2233 IQETRTYLL 2241
>XP_006717311
          Length = 2489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2238 IQETRTYLL 2246
>XP_006717310
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2218 IQETRTYLL 2226
>XP_006717309
          Length = 2505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2233 IQETRTYLL 2241
>XP_006717308
          Length = 2510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LEETSTYAL 9
            ++ET TY L
Sbjct: 2238 IQETRTYLL 2246
>XP_006714722
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_006714721
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LEETST 6
            LEETST
Sbjct: 1323 LEETST 1328
>XP_005247419
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LEETSTY 7
           LE+T TY
Sbjct: 970 LEQTDTY 976
>XP_005246602
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           L+ETST+
Sbjct: 137 LDETSTF 143
>XP_006712584
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           L+ETST+
Sbjct: 137 LDETSTF 143
>XP_005246601
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           L+ETST+
Sbjct: 137 LDETSTF 143
>XP_005246600
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LEETSTY 7
           L+ETST+
Sbjct: 137 LDETSTF 143
>NP_001167453
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LEETSTYAL 9
           LEE S Y L
Sbjct: 277 LEEDSNYVL 285
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.114    0.273 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 573,045
Number of extensions: 742
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package