Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           18    1482
NP_858045                                                              18    1482
NP_006525                                                              18    1482
NP_001167559                                                           18    1482
NP_653306                                                              17    3301
NP_001273488                                                           17    3301
NP_005302                                                              17    4312
NP_001001549                                                           17    4312
XP_006715767                                                           17    4312
XP_006715766                                                           17    4312
XP_005271818                                                           17    4312
XP_005271817                                                           17    4312
NP_149082                                                              16    5631
NP_148977                                                              16    5631
NP_006022                                                              16    5631
NP_065768                                                              16    5631
XP_006724654                                                           16    5631
XP_006724653                                                           16    5631
XP_005261186                                                           16    5631
XP_005261185                                                           16    5631
XP_005261184                                                           16    5631
XP_005261183                                                           16    5631
XP_005261182                                                           16    5631
XP_005261181                                                           16    5631
NP_057427                                                              16    7355
NP_078997                                                              16    7355
NP_055464                                                              16    7355
NP_002214                                                              16    7355
NP_079113                                                              16    7355
XP_006720758                                                           16    7355
XP_006720757                                                           16    7355
XP_006720756                                                           16    7355
XP_006719127                                                           16    7355
NP_005742                                                              15    9605
NP_671714                                                              15    9605
NP_689637                                                              15    9605
NP_002461                                                              15    9605
NP_001243888                                                           15    9605
NP_001277                                                              15    9605
NP_113602                                                              15    9605
NP_001247434                                                           15    9605
NP_006187                                                              15    9605
NP_116562                                                              15    9605
NP_001247433                                                           15    9605
NP_056254                                                              15    9605
NP_219479                                                              15    9605
NP_061938                                                              15    9605
XP_006726617                                                           15    9605
XP_005262298                                                           15    9605
XP_006721591                                                           15    9605
XP_006721263                                                           15    9605
XP_006720409                                                           15    9605
XP_006715890                                                           15    9605
XP_005250160                                                           15    9605
XP_005250159                                                           15    9605
XP_006715821                                                           15    9605
XP_005249868                                                           15    9605
XP_006710039                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDINAS E
Sbjct: 208 LEDINASPE 216
>NP_858045
          Length = 1424

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDINAS E
Sbjct: 208 LEDINASPE 216
>NP_006525
          Length = 1420

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDINAS E
Sbjct: 208 LEDINASPE 216
>NP_001167559
          Length = 1415

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDINAS E
Sbjct: 208 LEDINASPE 216
>NP_653306
          Length = 435

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDI+ SLE
Sbjct: 393 LEDIHMSLE 401
>NP_001273488
          Length = 253

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           LEDI+ SLE
Sbjct: 211 LEDIHMSLE 219
>NP_005302
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 56 VNDMNASLE 64
>NP_001001549
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 56 VNDMNASLE 64
>XP_006715767
          Length = 588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 50 VNDMNASLE 58
>XP_006715766
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 56 VNDMNASLE 64
>XP_005271818
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 56 VNDMNASLE 64
>XP_005271817
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEDINASLE 9
          + D+NASLE
Sbjct: 56 VNDMNASLE 64
>NP_149082
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           ++D+N SLE
Sbjct: 251 IQDVNYSLE 259
>NP_148977
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           ++D+N SLE
Sbjct: 277 IQDVNYSLE 285
>NP_006022
          Length = 3336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2687 LEELRASLE 2695
>NP_065768
          Length = 1493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEDINAS 7
            LEDINA+
Sbjct: 1336 LEDINAN 1342
>XP_006724654
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEDINAS 7
            LEDINA+
Sbjct: 1178 LEDINAN 1184
>XP_006724653
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LEDINAS 7
            LEDINA+
Sbjct: 1220 LEDINAN 1226
>XP_005261186
          Length = 3139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2569 LEELRASLE 2577
>XP_005261185
          Length = 3229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2580 LEELRASLE 2588
>XP_005261184
          Length = 3258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2698 LEELRASLE 2706
>XP_005261183
          Length = 3268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2698 LEELRASLE 2706
>XP_005261182
          Length = 3346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2697 LEELRASLE 2705
>XP_005261181
          Length = 3347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LE++ ASLE
Sbjct: 2698 LEELRASLE 2706
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LEDINASL 8
           L++INASL
Sbjct: 979 LKEINASL 986
>NP_078997
          Length = 3616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            LED++ SLE
Sbjct: 3585 LEDLDNSLE 3593
>NP_055464
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EDINASLE 9
           ED+ ASLE
Sbjct: 114 EDMEASLE 121
>NP_002214
          Length = 2701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            L+D+ ASLE
Sbjct: 1606 LQDVVASLE 1614
>NP_079113
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEDINASLE 9
           LED NA+ E
Sbjct: 615 LEDANAATE 623
>XP_006720758
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEDINASLE 9
           LED NA+ E
Sbjct: 652 LEDANAATE 660
>XP_006720757
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEDINASLE 9
           LED NA+ E
Sbjct: 431 LEDANAATE 439
>XP_006720756
          Length = 1229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEDINASLE 9
           LED NA+ E
Sbjct: 652 LEDANAATE 660
>XP_006719127
          Length = 1865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            L+D+ ASLE
Sbjct: 1606 LQDVVASLE 1614
>NP_005742
          Length = 3907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEDINASLE 9
            LED+  SLE
Sbjct: 3242 LEDLKFSLE 3250
>NP_671714
          Length = 3899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEDINASLE 9
            LED+  SLE
Sbjct: 3234 LEDLKFSLE 3242
>NP_689637
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EDINASLE 9
           ED+ ASLE
Sbjct: 832 EDLAASLE 839
>NP_002461
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            +ED+ +SLE
Sbjct: 1032 VEDLESSLE 1040
>NP_001243888
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EDINASLE 9
           ED+N+S++
Sbjct: 397 EDVNSSIK 404
>NP_001277
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EDINASLE 9
           ED+N+S++
Sbjct: 419 EDVNSSIK 426
>NP_113602
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 471 LQDLSVSLE 479
>NP_001247434
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 471 LQDLSVSLE 479
>NP_006187
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EDINASL 8
          EDIN+S+
Sbjct: 81 EDINSSM 87
>NP_116562
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 448 LQDLSVSLE 456
>NP_001247433
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 448 LQDLSVSLE 456
>NP_056254
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LEDINASLE 9
           LE++N+S++
Sbjct: 250 LEELNSSIQ 258
>NP_219479
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LEDINA 6
          LED+NA
Sbjct: 31 LEDVNA 36
>NP_061938
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EDINASLE 9
           ED+ ASLE
Sbjct: 131 EDVLASLE 138
>XP_006726617
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    LEDINASLE 9
            ++DINA+++
Sbjct: 1503 MQDINAAMK 1511
>XP_005262298
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EDINASLE 9
           ED+ ASLE
Sbjct: 555 EDLAASLE 562
>XP_006721591
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LEDINASLE 9
            +ED+ +SLE
Sbjct: 1032 VEDLESSLE 1040
>XP_006721263
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EDINASLE 9
          ED+ ASLE
Sbjct: 5  EDVLASLE 12
>XP_006720409
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    LEDINASLE 9
            ++DINA+++
Sbjct: 1503 MQDINAAMK 1511
>XP_006715890
          Length = 3860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEDINASLE 9
            LED+  SLE
Sbjct: 3195 LEDLKFSLE 3203
>XP_005250160
          Length = 3939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEDINASLE 9
            LED+  SLE
Sbjct: 3274 LEDLKFSLE 3282
>XP_005250159
          Length = 3952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEDINASLE 9
            LED+  SLE
Sbjct: 3287 LEDLKFSLE 3295
>XP_006715821
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 293 LQDLSVSLE 301
>XP_005249868
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEDINASLE 9
           L+D++ SLE
Sbjct: 471 LQDLSVSLE 479
>XP_006710039
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    LEDINASLE 9
            ++DINA+++
Sbjct: 1399 MQDINAAMK 1407
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.126    0.295 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,180
Number of extensions: 797
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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