Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1482
NP_001087241                                                           18    1482
XP_005265799                                                           18    1482
XP_005265798                                                           18    1482
XP_005265797                                                           18    1482
NP_005202                                                              17    4312
NP_002011                                                              17    4312
NP_891555                                                              17    4312
NP_000634                                                              17    4312
NP_000635                                                              17    4312
NP_000636                                                              17    4312
NP_000019                                                              17    4312
NP_000637                                                              17    4312
NP_000633                                                              17    4312
NP_001275634                                                           17    4312
NP_002244                                                              17    4312
NP_002010                                                              17    4312
NP_068379                                                              17    4312
NP_060392                                                              17    4312
XP_005270614                                                           17    4312
NP_000344                                                              16    5631
NP_006197                                                              16    7355
NP_001070                                                              16    7355
NP_997402                                                              16    7355
NP_001167639                                                           16    7355
NP_001167638                                                           16    7355
NP_001128524                                                           16    7355
NP_003168                                                              16    7355
NP_001973                                                              16    7355
NP_001316                                                              16    7355
NP_003322                                                              16    7355
NP_115604                                                              16    7355
XP_005252204                                                           16    7355
XP_005265800                                                           16    7355
XP_006714103                                                           16    7355
XP_006714102                                                           16    7355
XP_006712792                                                           16    7355
XP_006712791                                                           16    7355
XP_005264072                                                           16    7355
NP_065142                                                              16    7355
NP_073591                                                              16    7355
NP_056050                                                              16    7355
NP_004295                                                              15    9605
NP_002684                                                              15    9605
NP_001119603                                                           15    9605
NP_004751                                                              15    9605
>NP_000213
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L ARNILLT
Sbjct: 793 LAARNILLT 801
>NP_001087241
          Length = 972

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L ARNILLT
Sbjct: 789 LAARNILLT 797
>XP_005265799
          Length = 973

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L ARNILLT
Sbjct: 790 LAARNILLT 798
>XP_005265798
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L ARNILLT
Sbjct: 793 LAARNILLT 801
>XP_005265797
          Length = 977

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L ARNILLT
Sbjct: 794 LAARNILLT 802
>NP_005202
          Length = 972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARNILLT 9
           ARN+LLT
Sbjct: 781 ARNVLLT 787
>NP_002011
          Length = 1298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LEARNILLT 9
            L ARNILL+
Sbjct: 1038 LAARNILLS 1046
>NP_891555
          Length = 1363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LEARNILLT 9
            L ARNILL+
Sbjct: 1038 LAARNILLS 1046
>NP_000634
          Length = 1532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1118 VEARNIIL 1125
>NP_000635
          Length = 1532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1118 VEARNIIL 1125
>NP_000636
          Length = 1515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1101 VEARNIIL 1108
>NP_000019
          Length = 1532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1118 VEARNIIL 1125
>NP_000637
          Length = 1516

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1102 VEARNIIL 1109
>NP_000633
          Length = 1532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1118 VEARNIIL 1125
>NP_001275634
          Length = 972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARNILLT 9
           ARN+LLT
Sbjct: 781 ARNVLLT 787
>NP_002244
          Length = 1356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LEARNILLT 9
            L ARNILL+
Sbjct: 1029 LAARNILLS 1037
>NP_002010
          Length = 1338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LEARNILLT 9
            L ARNILL+
Sbjct: 1023 LAARNILLS 1031
>NP_068379
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L A+N+LLT
Sbjct: 527 LRAKNLLLT 535
>NP_060392
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   EARNILLT 9
           EARNIL T
Sbjct: 439 EARNILKT 446
>XP_005270614
          Length = 1532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LEARNILL 8
            +EARNI+L
Sbjct: 1118 VEARNIIL 1125
>NP_000344
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LEARNILLT 9
           LEA++++LT
Sbjct: 133 LEAKDVILT 141
>NP_006197
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 819 LAARNVLL 826
>NP_001070
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 462 LAARNVLL 469
>NP_997402
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 155 LAARNVLL 162
>NP_001167639
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 472 LAARNVLL 479
>NP_001167638
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 495 LAARNVLL 502
>NP_001128524
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 472 LAARNVLL 479
>NP_003168
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 495 LAARNVLL 502
>NP_001973
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 835 LAARNVLL 842
>NP_001316
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARNILL 8
           EARN+LL
Sbjct: 157 EARNMLL 163
>NP_003322
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LEARNILL 8
            L ARN+LL
Sbjct: 1024 LAARNVLL 1031
>NP_115604
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EARNILLT 9
          E +N+LLT
Sbjct: 9  EGKNVLLT 16
>XP_005252204
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 495 LAARNVLL 502
>XP_005265800
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 819 LAARNVLL 826
>XP_006714103
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 841 LAARNVLL 848
>XP_006714102
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 844 LAARNVLL 851
>XP_006712792
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 155 LAARNVLL 162
>XP_006712791
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 462 LAARNVLL 469
>XP_005264072
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           L ARN+LL
Sbjct: 456 LAARNVLL 463
>NP_065142
          Length = 250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L+ RN+LLT
Sbjct: 106 LKERNMLLT 114
>NP_073591
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EARNILLT 9
          + RNILLT
Sbjct: 33 DPRNILLT 40
>NP_056050
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARNILL 8
           EARN+LL
Sbjct: 157 EARNMLL 163
>NP_004295
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LEARNILLT 9
            + ARN LLT
Sbjct: 1250 IAARNCLLT 1258
>NP_002684
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           LEA N+LL
Sbjct: 151 LEAANLLL 158
>NP_001119603
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LEARNILL 8
           LEA N+LL
Sbjct: 151 LEAANLLL 158
>NP_004751
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEARNILLT 9
           L+ +NILLT
Sbjct: 187 LKPQNILLT 195
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.141    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 339,733
Number of extensions: 472
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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