Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_071934                                                              18    1135
NP_001026884                                                           18    1135
XP_005268062                                                           18    1135
XP_005268061                                                           18    1135
NP_001120929                                                           17    2528
NP_066940                                                              17    2528
NP_001153605                                                           17    4312
NP_062816                                                              17    4312
NP_001153606                                                           17    4312
NP_001153602                                                           17    4312
NP_001153604                                                           17    4312
NP_006586                                                              16    5631
NP_001136402                                                           16    5631
NP_001136403                                                           16    5631
NP_001230676                                                           16    5631
NP_061836                                                              16    5631
NP_387505                                                              16    5631
NP_057582                                                              16    5631
XP_006718422                                                           16    5631
NP_001005619                                                           16    7355
NP_001005731                                                           16    7355
NP_000204                                                              16    7355
NP_001127928                                                           16    7355
NP_659474                                                              16    7355
XP_005257369                                                           16    7355
XP_005257368                                                           16    7355
XP_006721933                                                           16    7355
XP_006721932                                                           16    7355
XP_006721931                                                           16    7355
XP_006721930                                                           16    7355
XP_005257366                                                           16    7355
XP_006721929                                                           16    7355
NP_003946                                                              15    9605
NP_598328                                                              15    9605
NP_002497                                                              15    9605
NP_775786                                                              15    9605
NP_148983                                                              15    9605
NP_002598                                                              15    9605
NP_008881                                                              15    9605
NP_510880                                                              15    9605
NP_976063                                                              15    9605
XP_006715796                                                           15    9605
XP_005249827                                                           15    9605
XP_006713376                                                           15    9605
XP_006713375                                                           15    9605
XP_006710728                                                           15    9605
XP_006710727                                                           15    9605
XP_006710726                                                           15    9605
>NP_071934
          Length = 1249

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LDTSLRKSF 9
            LDTSL KSF
Sbjct: 1185 LDTSLDKSF 1193
>NP_001026884
          Length = 1240

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LDTSLRKSF 9
            LDTSL KSF
Sbjct: 1185 LDTSLDKSF 1193
>XP_005268062
          Length = 1272

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LDTSLRKSF 9
            LDTSL KSF
Sbjct: 1217 LDTSLDKSF 1225
>XP_005268061
          Length = 1281

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LDTSLRKSF 9
            LDTSL KSF
Sbjct: 1217 LDTSLDKSF 1225
>NP_001120929
          Length = 532

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  LDTSLRK 7
          LDTSLRK
Sbjct: 20 LDTSLRK 26
>NP_066940
          Length = 614

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDTSLRK 7
           LDTSLRK
Sbjct: 102 LDTSLRK 108
>NP_001153605
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTSLRKSF 9
           D S+RKSF
Sbjct: 820 DRSMRKSF 827
>NP_062816
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTSLRKSF 9
           D S+RKSF
Sbjct: 801 DRSMRKSF 808
>NP_001153606
          Length = 822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTSLRKSF 9
           D S+RKSF
Sbjct: 691 DRSMRKSF 698
>NP_001153602
          Length = 923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTSLRKSF 9
           D S+RKSF
Sbjct: 792 DRSMRKSF 799
>NP_001153604
          Length = 942

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DTSLRKSF 9
           D S+RKSF
Sbjct: 811 DRSMRKSF 818
>NP_006586
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           L+T+LRK F
Sbjct: 303 LETNLRKLF 311
>NP_001136402
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           L+T+LRK F
Sbjct: 303 LETNLRKLF 311
>NP_001136403
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           L+T+LRK F
Sbjct: 249 LETNLRKLF 257
>NP_001230676
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           L+T+LRK F
Sbjct: 130 LETNLRKLF 138
>NP_061836
          Length = 2320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DTSLRKS 8
           DT+LRKS
Sbjct: 949 DTTLRKS 955
>NP_387505
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DTSLRKS 8
           DT+LRKS
Sbjct: 949 DTTLRKS 955
>NP_057582
          Length = 166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           LD+SLRK +
Sbjct: 149 LDSSLRKLY 157
>XP_006718422
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDTSLRKSF 9
           L+T+LRK F
Sbjct: 303 LETNLRKLF 311
>NP_001005619
          Length = 1805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>NP_001005731
          Length = 1752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>NP_000204
          Length = 1822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>NP_001127928
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDTSLRKSF 9
           LDT LR+ F
Sbjct: 505 LDTILRRMF 513
>NP_659474
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDTSLRKSF 9
           LDT LR+ F
Sbjct: 505 LDTILRRMF 513
>XP_005257369
          Length = 1752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>XP_005257368
          Length = 1875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>XP_006721933
          Length = 1787

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDTSLRKS 8
           +DT+LR+S
Sbjct: 127 IDTTLRRS 134
>XP_006721932
          Length = 1821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 38 IDTTLRRS 45
>XP_006721931
          Length = 1840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDTSLRKS 8
           +DT+LR+S
Sbjct: 127 IDTTLRRS 134
>XP_006721930
          Length = 1857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDTSLRKS 8
           +DT+LR+S
Sbjct: 127 IDTTLRRS 134
>XP_005257366
          Length = 1875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          +DT+LR+S
Sbjct: 92 IDTTLRRS 99
>XP_006721929
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDTSLRKS 8
           +DT+LR+S
Sbjct: 127 IDTTLRRS 134
>NP_003946
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LDTSLR 6
          LDTSLR
Sbjct: 16 LDTSLR 21
>NP_598328
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLRKSF 9
           SLRKSF
Sbjct: 571 SLRKSF 576
>NP_002497
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          LDT+LR++
Sbjct: 44 LDTALRRA 51
>NP_775786
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LDTSLRK 7
           +DTSL+K
Sbjct: 330 MDTSLKK 336
>NP_148983
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LDTSLR 6
          LDTSLR
Sbjct: 59 LDTSLR 64
>NP_002598
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LDTSLR 6
          LDTSLR
Sbjct: 59 LDTSLR 64
>NP_008881
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLRKSF 9
           SLRKSF
Sbjct: 694 SLRKSF 699
>NP_510880
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TSLRKSF 9
            TS+RK+F
Sbjct: 1003 TSMRKTF 1009
>NP_976063
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TSLRKSF 9
            TS+RK+F
Sbjct: 1003 TSMRKTF 1009
>XP_006715796
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LDTSLR 6
          LDTSLR
Sbjct: 59 LDTSLR 64
>XP_005249827
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LDTSLR 6
          LDTSLR
Sbjct: 73 LDTSLR 78
>XP_006713376
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLRKSF 9
           SLRKSF
Sbjct: 314 SLRKSF 319
>XP_006713375
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLRKSF 9
           SLRKSF
Sbjct: 410 SLRKSF 415
>XP_006710728
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          LDT+LR++
Sbjct: 44 LDTALRRA 51
>XP_006710727
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          LDT+LR++
Sbjct: 44 LDTALRRA 51
>XP_006710726
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LDTSLRKS 8
          LDT+LR++
Sbjct: 44 LDTALRRA 51
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.132    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 467,188
Number of extensions: 866
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package