Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           19     665
NP_000170                                                              19     665
NP_001268422                                                           19     665
NP_001268423                                                           19     665
XP_005264328                                                           19     665
NP_060116                                                              18    1935
XP_006710769                                                           18    1935
XP_005271011                                                           18    1935
NP_115984                                                              17    2528
NP_690007                                                              17    3301
NP_690008                                                              17    3301
NP_071907                                                              17    3301
XP_005259213                                                           17    3301
XP_005259212                                                           17    3301
XP_005259211                                                           17    3301
XP_006723388                                                           17    3301
XP_005259210                                                           17    3301
XP_006723387                                                           17    3301
XP_005259209                                                           17    3301
NP_690009                                                              17    3301
NP_003244                                                              17    4312
XP_005261096                                                           17    4312
XP_005261095                                                           17    4312
XP_005261094                                                           17    4312
NP_005436                                                              16    7355
NP_056125                                                              16    7355
XP_006726589                                                           16    7355
XP_006718462                                                           16    7355
XP_005273518                                                           16    7355
XP_006716381                                                           16    7355
XP_006710010                                                           16    7355
NP_001005207                                                           15    9605
NP_056109                                                              15    9605
NP_001258540                                                           15    9605
NP_001258539                                                           15    9605
NP_003756                                                              15    9605
NP_060439                                                              15    9605
NP_001075                                                              15    9605
NP_001258538                                                           15    9605
XP_005257447                                                           15    9605
XP_005257446                                                           15    9605
XP_005257445                                                           15    9605
XP_005257444                                                           15    9605
XP_005257443                                                           15    9605
XP_005257442                                                           15    9605
XP_006712689                                                           15    9605
XP_005263764                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LDSD VSTT
Sbjct: 582 LDSDTVSTT 590
>NP_000170
          Length = 1360

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LDSD VSTT
Sbjct: 712 LDSDTVSTT 720
>NP_001268422
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LDSD VSTT
Sbjct: 410 LDSDTVSTT 418
>NP_001268423
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LDSD VSTT
Sbjct: 410 LDSDTVSTT 418
>XP_005264328
          Length = 1261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LDSD VSTT
Sbjct: 613 LDSDTVSTT 621
>NP_060116
          Length = 467

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDSDAVST 8
           LDSDAV+T
Sbjct: 429 LDSDAVNT 436
>XP_006710769
          Length = 326

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDSDAVST 8
           LDSDAV+T
Sbjct: 288 LDSDAVNT 295
>XP_005271011
          Length = 386

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDSDAVST 8
           LDSDAV+T
Sbjct: 348 LDSDAVNT 355
>NP_115984
          Length = 817

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LDSDAVSTT 9
           LD+DAVS T
Sbjct: 199 LDADAVSPT 207
>NP_690007
          Length = 667

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 279 LDSDAVS 285
>NP_690008
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 281 LDSDAVS 287
>NP_071907
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 212 LDSDAVS 218
>XP_005259213
          Length = 587

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 325 LDSDAVS 331
>XP_005259212
          Length = 587

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 325 LDSDAVS 331
>XP_005259211
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 212 LDSDAVS 218
>XP_006723388
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 212 LDSDAVS 218
>XP_005259210
          Length = 612

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 230 LDSDAVS 236
>XP_006723387
          Length = 667

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 279 LDSDAVS 285
>XP_005259209
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 325 LDSDAVS 331
>NP_690009
          Length = 450

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LDSDAVS 7
           LDSDAVS
Sbjct: 212 LDSDAVS 218
>NP_003244
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LDSDAVSTT 9
            +DSDAVS +
Sbjct: 1457 IDSDAVSAS 1465
>XP_005261096
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LDSDAVSTT 9
            +DSDAVS +
Sbjct: 1457 IDSDAVSAS 1465
>XP_005261095
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LDSDAVSTT 9
            +DSDAVS +
Sbjct: 1457 IDSDAVSAS 1465
>XP_005261094
          Length = 1591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LDSDAVSTT 9
            +DSDAVS +
Sbjct: 1457 IDSDAVSAS 1465
>NP_005436
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDSDAVST 8
           +DSD VST
Sbjct: 563 VDSDEVST 570
>NP_056125
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDSDAVST 8
           LD DAVS+
Sbjct: 156 LDQDAVSS 163
>XP_006726589
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDSDAVSTT 9
           +DSD  STT
Sbjct: 109 VDSDCPSTT 117
>XP_006718462
          Length = 4966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LDSDAVSTT 9
            +DSD  STT
Sbjct: 4134 VDSDCPSTT 4142
>XP_005273518
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDSDAVST 8
           LD DAVS+
Sbjct: 156 LDQDAVSS 163
>XP_006716381
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDSDAVST 8
           LD DAVS+
Sbjct: 123 LDQDAVSS 130
>XP_006710010
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDSDAVSTT 9
           +DSD  STT
Sbjct: 330 VDSDCPSTT 338
>NP_001005207
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 833 LDSDAV 838
>NP_056109
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 833 LDSDAV 838
>NP_001258540
          Length = 200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LDSDAVSTT 9
          LD+ AVS T
Sbjct: 88 LDASAVSAT 96
>NP_001258539
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDSDAVSTT 9
           LD+ AVS T
Sbjct: 137 LDASAVSAT 145
>NP_003756
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDSDAVSTT 9
           LD+ AVS T
Sbjct: 137 LDASAVSAT 145
>NP_060439
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSDAVS 7
           DSDAVS
Sbjct: 421 DSDAVS 426
>NP_001075
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LDSDAVST 8
           LD+DAV T
Sbjct: 391 LDADAVLT 398
>NP_001258538
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDSDAVSTT 9
           LD+ AVS T
Sbjct: 137 LDASAVSAT 145
>XP_005257447
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 833 LDSDAV 838
>XP_005257446
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 833 LDSDAV 838
>XP_005257445
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 790 LDSDAV 795
>XP_005257444
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 799 LDSDAV 804
>XP_005257443
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 799 LDSDAV 804
>XP_005257442
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDSDAV 6
           LDSDAV
Sbjct: 833 LDSDAV 838
>XP_006712689
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSDAVS 7
           DSDAVS
Sbjct: 426 DSDAVS 431
>XP_005263764
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DSDAVS 7
           DSDAVS
Sbjct: 426 DSDAVS 431
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.108    0.256 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,070
Number of extensions: 534
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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