Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              18    1482
NP_001277131                                                           18    1482
NP_849191                                                              18    1482
NP_001092105                                                           18    1482
NP_065916                                                              17    4312
NP_001107869                                                           17    4312
NP_001229759                                                           16    7355
NP_068586                                                              16    7355
NP_001229757                                                           16    7355
NP_062548                                                              16    7355
NP_001348                                                              16    7355
NP_001136069                                                           16    7355
XP_006718488                                                           16    7355
XP_005249324                                                           16    7355
XP_005249323                                                           16    7355
NP_006822                                                              16    7355
NP_612480                                                              16    7355
NP_001026                                                              15    9605
NP_976041                                                              15    9605
NP_976042                                                              15    9605
NP_976040                                                              15    9605
NP_976038                                                              15    9605
NP_976039                                                              15    9605
NP_001258                                                              15    9605
XP_006726201                                                           15    9605
XP_006714986                                                           15    9605
XP_006711873                                                           15    9605
XP_006711872                                                           15    9605
XP_006711871                                                           15    9605
XP_006711870                                                           15    9605
XP_006711869                                                           15    9605
XP_006711868                                                           15    9605
XP_006711867                                                           15    9605
XP_006711866                                                           15    9605
XP_006711865                                                           15    9605
>NP_115803
          Length = 1156

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LDIK IRVG
Sbjct: 201 LDIKRIRVG 209
>NP_001277131
          Length = 869

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LDIKIIRVG 9
           LDI+++R+G
Sbjct: 508 LDIRVLRIG 516
>NP_849191
          Length = 994

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LDIKIIRVG 9
           LDI+++R+G
Sbjct: 633 LDIRVLRIG 641
>NP_001092105
          Length = 993

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LDIKIIRVG 9
           LDI+++R+G
Sbjct: 633 LDIRVLRIG 641
>NP_065916
          Length = 1008

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           L IKI+R+G
Sbjct: 641 LQIKILRLG 649
>NP_001107869
          Length = 994

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           L IKI+R+G
Sbjct: 627 LQIKILRLG 635
>NP_001229759
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DIKIIRV 8
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>NP_068586
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DIKIIRV 8
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>NP_001229757
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DIKIIRV 8
           D+KIIRV
Sbjct: 133 DMKIIRV 139
>NP_062548
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K++ +G
Sbjct: 354 LDLKVVSLG 362
>NP_001348
          Length = 1270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           L IK++R+G
Sbjct: 803 LSIKLLRLG 811
>NP_001136069
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DIKIIRVG 9
           D+KI +VG
Sbjct: 259 DVKIYKVG 266
>XP_006718488
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DIKIIRVG 9
           D+KI +VG
Sbjct: 323 DVKIYKVG 330
>XP_005249324
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DIKIIRV 8
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>XP_005249323
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DIKIIRV 8
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>NP_006822
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DIKIIRVG 9
           D+KI +VG
Sbjct: 323 DVKIYKVG 330
>NP_612480
          Length = 381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDIKIIRV 8
           LD+++IRV
Sbjct: 321 LDLQVIRV 328
>NP_001026
          Length = 4967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>NP_976041
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 151 LDLKGVRLG 159
>NP_976042
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 177 LDLKGVRLG 185
>NP_976040
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 151 LDLKGVRLG 159
>NP_976038
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 359 LDLKGVRLG 367
>NP_976039
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 151 LDLKGVRLG 159
>NP_001258
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DIKIIRVG 9
           DI+++R G
Sbjct: 110 DIRVLRAG 117
>XP_006726201
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K++ +G
Sbjct: 144 LDLKVVGLG 152
>XP_006714986
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           LD+K +R+G
Sbjct: 151 LDLKGVRLG 159
>XP_006711873
          Length = 4954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711872
          Length = 2735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711871
          Length = 4906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711870
          Length = 4965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711869
          Length = 4973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711868
          Length = 4975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711867
          Length = 4977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711866
          Length = 4984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
>XP_006711865
          Length = 4985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDIKIIRVG 9
           +D+K +R+G
Sbjct: 377 VDVKSVRMG 385
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.167    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,217
Number of extensions: 619
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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