Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           20     390
NP_000242                                                              20     390
XP_005264389                                                           20     390
XP_003960787                                                           17    2528
XP_003118801                                                           17    2528
XP_003119723                                                           17    2528
NP_056263                                                              17    3301
NP_055452                                                              17    3301
NP_001139311                                                           17    3301
XP_006717808                                                           17    3301
XP_005251384                                                           17    3301
XP_006716547                                                           17    3301
NP_001139310                                                           17    3301
NP_059107                                                              16    7355
NP_075013                                                              16    7355
NP_075014                                                              16    7355
NP_000335                                                              16    7355
NP_075015                                                              16    7355
NP_075012                                                              16    7355
NP_003986                                                              16    7355
NP_079303                                                              16    7355
XP_005248632                                                           16    7355
XP_005276832                                                           16    7355
XP_005259334                                                           16    7355
XP_005259333                                                           16    7355
XP_005251536                                                           16    7355
XP_006716841                                                           16    7355
XP_005251535                                                           16    7355
XP_006714740                                                           16    7355
NP_000543                                                              15    9605
NP_060617                                                              15    9605
NP_001028204                                                           15    9605
NP_001028203                                                           15    9605
NP_001028202                                                           15    9605
NP_085152                                                              15    9605
XP_006709992                                                           15    9605
XP_005244773                                                           15    9605
XP_005244772                                                           15    9605
XP_006710392                                                           15    9605
XP_006710191                                                           15    9605
NP_001004688                                                           15    9605
NP_001004691                                                           15    9605
NP_001004690                                                           15    9605
>NP_001245210
          Length = 868

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDAVASFAH 9
           LDAV SFAH
Sbjct: 536 LDAVVSFAH 544
>NP_000242
          Length = 934

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDAVASFAH 9
           LDAV SFAH
Sbjct: 602 LDAVVSFAH 610
>XP_005264389
          Length = 921

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LDAVASFAH 9
           LDAV SFAH
Sbjct: 602 LDAVVSFAH 610
>XP_003960787
          Length = 675

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           LDAVA+FA
Sbjct: 511 LDAVAAFA 518
>XP_003118801
          Length = 675

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           LDAVA+FA
Sbjct: 511 LDAVAAFA 518
>XP_003119723
          Length = 675

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           LDAVA+FA
Sbjct: 511 LDAVAAFA 518
>NP_056263
          Length = 203

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAVASFAH 9
           DA+ SFAH
Sbjct: 154 DALLSFAH 161
>NP_055452
          Length = 333

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  DAVASFA 8
          DAVASFA
Sbjct: 71 DAVASFA 77
>NP_001139311
          Length = 348

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  DAVASFA 8
          DAVASFA
Sbjct: 71 DAVASFA 77
>XP_006717808
          Length = 373

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAVASFAH 9
           DA+ SFAH
Sbjct: 324 DALLSFAH 331
>XP_005251384
          Length = 320

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  DAVASFA 8
          DAVASFA
Sbjct: 58 DAVASFA 64
>XP_006716547
          Length = 348

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  DAVASFA 8
          DAVASFA
Sbjct: 71 DAVASFA 77
>NP_001139310
          Length = 300

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  DAVASFA 8
          DAVASFA
Sbjct: 38 DAVASFA 44
>NP_059107
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_075013
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_075014
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_000335
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_075015
          Length = 250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_075012
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_003986
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LDAVASF 7
           LDAV+SF
Sbjct: 938 LDAVSSF 944
>NP_079303
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DAVASFAH 9
           DAV SF H
Sbjct: 293 DAVKSFNH 300
>XP_005248632
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>XP_005276832
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>XP_005259334
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DAVASFAH 9
           DAV SF H
Sbjct: 203 DAVKSFNH 210
>XP_005259333
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DAVASFAH 9
           DAV SF H
Sbjct: 293 DAVKSFNH 300
>XP_005251536
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LDAVASF 7
           LDAV+SF
Sbjct: 612 LDAVSSF 618
>XP_006716841
          Length = 1026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LDAVASF 7
           LDAV+SF
Sbjct: 917 LDAVSSF 923
>XP_005251535
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LDAVASF 7
           LDAV+SF
Sbjct: 941 LDAVSSF 947
>XP_006714740
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AVASFAH 9
          AVASF H
Sbjct: 46 AVASFKH 52
>NP_000543
          Length = 2813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DAVASFAH 9
            + +AS+AH
Sbjct: 2175 EVIASYAH 2182
>NP_060617
          Length = 179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LDAVASFAH 9
          +DA++ FA+
Sbjct: 67 IDAISGFAY 75
>NP_001028204
          Length = 179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LDAVASFAH 9
          +DA++ FA+
Sbjct: 67 IDAISGFAY 75
>NP_001028203
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LDAVASFAH 9
          +DA++ FA+
Sbjct: 89 IDAISGFAY 97
>NP_001028202
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LDAVASFAH 9
           +DA++ FA+
Sbjct: 101 IDAISGFAY 109
>NP_085152
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDAVASFAH 9
           LD++ SF H
Sbjct: 187 LDSMLSFMH 195
>XP_006709992
          Length = 1311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAVASFAH 9
           DAV SFA+
Sbjct: 899 DAVLSFAN 906
>XP_005244773
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDAVASFAH 9
           LD++ SF H
Sbjct: 145 LDSMLSFMH 153
>XP_005244772
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDAVASFAH 9
           LD++ SF H
Sbjct: 187 LDSMLSFMH 195
>XP_006710392
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LDAVASFAH 9
           LD++ SF H
Sbjct: 187 LDSMLSFMH 195
>XP_006710191
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DAVASFAH 9
            DAV SFA+
Sbjct: 1282 DAVLSFAN 1289
>NP_001004688
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           +DAVA+F+
Sbjct: 158 IDAVATFS 165
>NP_001004691
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           +DAVA+F+
Sbjct: 158 IDAVATFS 165
>NP_001004690
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LDAVASFA 8
           +DAVA+F+
Sbjct: 158 IDAVATFS 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.128    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 313,668
Number of extensions: 444
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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