Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     509
NP_066124                                                              20     509
XP_006717999                                                           20     509
NP_001707                                                              17    3301
NP_116743                                                              17    3301
NP_001186948                                                           17    3301
NP_057209                                                              17    3301
NP_872588                                                              17    3301
NP_000904                                                              17    3301
XP_006723863                                                           17    3301
XP_005260263                                                           17    3301
XP_006723862                                                           17    3301
NP_001107033                                                           17    4312
NP_001027004                                                           17    4312
NP_543155                                                              17    4312
XP_005262140                                                           17    4312
XP_006714654                                                           17    4312
XP_006714653                                                           17    4312
XP_006714652                                                           17    4312
NP_001274143                                                           16    5631
NP_001274145                                                           16    5631
NP_001625                                                              16    5631
NP_001274144                                                           16    5631
NP_066919                                                              16    5631
NP_001003406                                                           16    5631
XP_006724411                                                           16    5631
NP_000827                                                              16    5631
NP_001268718                                                           16    7355
NP_694993                                                              16    7355
NP_001265482                                                           16    7355
NP_009077                                                              16    7355
NP_955453                                                              16    7355
NP_000826                                                              16    7355
XP_005257701                                                           16    7355
XP_005257700                                                           16    7355
XP_006721911                                                           16    7355
XP_006721910                                                           16    7355
XP_006721909                                                           16    7355
XP_006721908                                                           16    7355
NP_543143                                                              16    7355
NP_002973                                                              15    9605
NP_006210                                                              15    9605
NP_061956                                                              15    9605
XP_005247589                                                           15    9605
XP_006713722                                                           15    9605
XP_005247588                                                           15    9605
XP_005247587                                                           15    9605
XP_005271002                                                           15    9605
>NP_065681
          Length = 1072

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LCRTVIAA
Sbjct: 633 LCRTVIAA 640
>NP_066124
          Length = 1114

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LCRTVIAA
Sbjct: 633 LCRTVIAA 640
>XP_006717999
          Length = 1207

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LCRTVIAA
Sbjct: 726 LCRTVIAA 733
>NP_001707
          Length = 372

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 121 LCKTVIA 127
>NP_116743
          Length = 327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LCRTVIA 7
          LC+TVIA
Sbjct: 76 LCKTVIA 82
>NP_001186948
          Length = 370

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 122 LCKTVIA 128
>NP_057209
          Length = 435

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LCRTVI+
Sbjct: 411 LCRTVIS 417
>NP_872588
          Length = 370

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 122 LCKTVIA 128
>NP_000904
          Length = 370

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 122 LCKTVIA 128
>XP_006723863
          Length = 289

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LCRTVIA 7
          LC+TVIA
Sbjct: 41 LCKTVIA 47
>XP_005260263
          Length = 365

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 117 LCKTVIA 123
>XP_006723862
          Length = 370

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+TVIA
Sbjct: 122 LCKTVIA 128
>NP_001107033
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LCRT+I+
Sbjct: 472 LCRTIIS 478
>NP_001027004
          Length = 278

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CRTVIAAT 9
           CRT+++ T
Sbjct: 197 CRTIVSCT 204
>NP_543155
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CRTVIAAT 9
           CRT+++ T
Sbjct: 197 CRTIVSCT 204
>XP_005262140
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CRTVIAAT 9
           CRT+++ T
Sbjct: 197 CRTIVSCT 204
>XP_006714654
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LCRT+I+
Sbjct: 472 LCRTIIS 478
>XP_006714653
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LCRT+I+
Sbjct: 472 LCRTIIS 478
>XP_006714652
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LCRT+I+
Sbjct: 472 LCRTIIS 478
>NP_001274143
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CRTVIAA 8
           CRTV+A+
Sbjct: 263 CRTVLAS 269
>NP_001274145
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CRTVIAA 8
           CRTV+A+
Sbjct: 172 CRTVLAS 178
>NP_001625
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CRTVIAA 8
           CRTV+A+
Sbjct: 292 CRTVLAS 298
>NP_001274144
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CRTVIAA 8
           CRTV+A+
Sbjct: 223 CRTVLAS 229
>NP_066919
          Length = 2223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LCRTVIA 7
            LC+T+IA
Sbjct: 1162 LCQTIIA 1168
>NP_001003406
          Length = 2188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LCRTVIA 7
            LC+T+IA
Sbjct: 1127 LCQTIIA 1133
>XP_006724411
          Length = 1528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LCRTVIA 7
           LC+T+IA
Sbjct: 467 LCQTIIA 473
>NP_000827
          Length = 1336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 592 MCLTVVAVT 600
>NP_001268718
          Length = 125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTVIA 7
           CRTV+A
Sbjct: 99  CRTVLA 104
>NP_694993
          Length = 142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTVIA 7
           CRTV+A
Sbjct: 116 CRTVLA 121
>NP_001265482
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 562 MCLTVVAIT 570
>NP_009077
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           LC+T  AAT
Sbjct: 384 LCQTSTAAT 392
>NP_955453
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LCRTVI 6
           +CRTVI
Sbjct: 392 ICRTVI 397
>NP_000826
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 562 MCLTVVAIT 570
>XP_005257701
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           LC+T  AAT
Sbjct: 381 LCQTSTAAT 389
>XP_005257700
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           LC+T  AAT
Sbjct: 390 LCQTSTAAT 398
>XP_006721911
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 626 MCLTVVAIT 634
>XP_006721910
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 637 MCLTVVAIT 645
>XP_006721909
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 636 MCLTVVAIT 644
>XP_006721908
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCRTVIAAT 9
           +C TV+A T
Sbjct: 637 MCLTVVAIT 645
>NP_543143
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LCRTVI 6
           +CRTVI
Sbjct: 392 ICRTVI 397
>NP_002973
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LCRTVIAAT 9
          LC  +IAAT
Sbjct: 8  LCLLLIAAT 16
>NP_006210
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LC+T++++
Sbjct: 364 LCKTIVSS 371
>NP_061956
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  CRTVIAA 8
          CR V+AA
Sbjct: 30 CRMVVAA 36
>XP_005247589
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LC+T++++
Sbjct: 364 LCKTIVSS 371
>XP_006713722
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LC+T++++
Sbjct: 364 LCKTIVSS 371
>XP_005247588
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LC+T++++
Sbjct: 364 LCKTIVSS 371
>XP_005247587
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1   LCRTVIAA 8
           LC+T++++
Sbjct: 364 LCKTIVSS 371
>XP_005271002
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  CRTVIAA 8
          CR V+AA
Sbjct: 30 CRMVVAA 36
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,340
Number of extensions: 394
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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