Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     390
NP_066124                                                              20     390
XP_006717999                                                           20     390
NP_006747                                                              17    3301
NP_958845                                                              17    3301
XP_006716530                                                           17    3301
NP_071765                                                              16    7355
NP_037529                                                              16    7355
NP_653240                                                              16    7355
NP_001159446                                                           16    7355
NP_775113                                                              15    9605
NP_077320                                                              15    9605
NP_775111                                                              15    9605
NP_775110                                                              15    9605
NP_775112                                                              15    9605
NP_000061                                                              15    9605
NP_001171940                                                           15    9605
NP_689512                                                              15    9605
NP_001003793                                                           15    9605
NP_001003792                                                           15    9605
XP_005261969                                                           15    9605
XP_005265122                                                           15    9605
XP_005265120                                                           15    9605
XP_005265121                                                           15    9605
XP_006713171                                                           15    9605
XP_005265119                                                           15    9605
XP_005265118                                                           15    9605
XP_005265117                                                           15    9605
>NP_065681
          Length = 1072

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LCRTMIAAA 9
           LCRT+IAAA
Sbjct: 633 LCRTVIAAA 641
>NP_066124
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LCRTMIAAA 9
           LCRT+IAAA
Sbjct: 633 LCRTVIAAA 641
>XP_006717999
          Length = 1207

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LCRTMIAAA 9
           LCRT+IAAA
Sbjct: 726 LCRTVIAAA 734
>NP_006747
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CRTMIAAA 9
           CR M+AAA
Sbjct: 144 CREMLAAA 151
>NP_958845
          Length = 280

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CRTMIAAA 9
           CR M+AAA
Sbjct: 123 CREMLAAA 130
>XP_006716530
          Length = 254

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CRTMIAAA 9
           CR M+AAA
Sbjct: 97  CREMLAAA 104
>NP_071765
          Length = 1386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LCRTMIAAA 9
           L RT++AAA
Sbjct: 840 LYRTLVAAA 848
>NP_037529
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LCRTMIAAA 9
           L RT++AAA
Sbjct: 283 LSRTLLAAA 291
>NP_653240
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CRTMIAAA 9
           C+T +AAA
Sbjct: 95  CQTKVAAA 102
>NP_001159446
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CRTMIAAA 9
           C+T +AAA
Sbjct: 95  CQTKVAAA 102
>NP_775113
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRTMIA 7
          CR+MIA
Sbjct: 32 CRSMIA 37
>NP_077320
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTMIA 7
           CR+MIA
Sbjct: 691 CRSMIA 696
>NP_775111
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTMIA 7
           CR+MIA
Sbjct: 185 CRSMIA 190
>NP_775110
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTMIA 7
           CR+MIA
Sbjct: 605 CRSMIA 610
>NP_775112
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRTMIA 7
          CR+MIA
Sbjct: 32 CRSMIA 37
>NP_000061
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRTMIA 7
           CR+MIA
Sbjct: 697 CRSMIA 702
>NP_001171940
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCRTMIAA 8
           +CR+M+A+
Sbjct: 550 VCRSMLAS 557
>NP_689512
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCRTMIAA 8
           +CR+M+A+
Sbjct: 549 VCRSMLAS 556
>NP_001003793
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 364 LCQYMTAAA 372
>NP_001003792
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 346 LCQYMTAAA 354
>XP_005261969
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCRTMIAA 8
           +CR+M+A+
Sbjct: 523 VCRSMLAS 530
>XP_005265122
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 255 LCQYMTAAA 263
>XP_005265120
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 269 LCQYMTAAA 277
>XP_005265121
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 269 LCQYMTAAA 277
>XP_006713171
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 330 LCQYMTAAA 338
>XP_005265119
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 347 LCQYMTAAA 355
>XP_005265118
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 347 LCQYMTAAA 355
>XP_005265117
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCRTMIAAA 9
           LC+ M AAA
Sbjct: 363 LCQYMTAAA 371
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.131    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 410,995
Number of extensions: 326
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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