Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_006725527                                                           18    1935
XP_006714809                                                           18    1935
NP_001004058                                                           17    3301
NP_006824                                                              17    3301
NP_001004462                                                           17    4312
NP_001040                                                              17    4312
NP_783853                                                              17    4312
NP_001230028                                                           17    4312
NP_000555                                                              17    4312
XP_005247166                                                           17    4312
NP_001073909                                                           17    4312
NP_001004463                                                           17    4312
NP_001004464                                                           17    4312
NP_775869                                                              16    5631
NP_945344                                                              16    5631
XP_005257358                                                           16    5631
XP_006719420                                                           16    5631
NP_001136336                                                           16    7355
NP_001167594                                                           16    7355
XP_006722587                                                           16    7355
XP_006721417                                                           16    7355
XP_006721416                                                           16    7355
NP_001166031                                                           15    9605
NP_001044                                                              15    9605
NP_110447                                                              15    9605
NP_001683                                                              15    9605
NP_001265616                                                           15    9605
NP_001042                                                              15    9605
NP_001185951                                                           15    9605
NP_055526                                                              15    9605
NP_659403                                                              15    9605
NP_001171175                                                           15    9605
NP_055211                                                              15    9605
NP_001684                                                              15    9605
XP_005261778                                                           15    9605
XP_006724374                                                           15    9605
XP_006721168                                                           15    9605
XP_005255778                                                           15    9605
XP_005255776                                                           15    9605
XP_006720999                                                           15    9605
XP_006716792                                                           15    9605
XP_005251441                                                           15    9605
XP_005251440                                                           15    9605
XP_006716786                                                           15    9605
XP_005251439                                                           15    9605
XP_006715287                                                           15    9605
XP_006715286                                                           15    9605
XP_005264425                                                           15    9605
NP_542198                                                              15    9605
>XP_006725527
          Length = 1322

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LCHVLIILS 9
          LC +L+ILS
Sbjct: 80 LCSILVILS 88
>XP_006714809
          Length = 1574

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LCHVLIILS 9
          LC +L+ILS
Sbjct: 80 LCSILVILS 88
>NP_001004058
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LCHVLI 6
           LCHVL+
Sbjct: 140 LCHVLV 145
>NP_006824
          Length = 327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LCHVLIILS 9
           LCH L +LS
Sbjct: 263 LCHCLPVLS 271
>NP_001004462
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CHVLIILS 9
           C VLI+LS
Sbjct: 209 CFVLIVLS 216
>NP_001040
          Length = 391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LCHVLII 7
           LC+VLII
Sbjct: 241 LCYVLII 247
>NP_783853
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LCHVLIILS 9
           +C +L+ILS
Sbjct: 351 ICFILLILS 359
>NP_001230028
          Length = 378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LCHVLIILS 9
           +C +L+ILS
Sbjct: 351 ICFILLILS 359
>NP_000555
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LCHVLIILS 9
           +C +L+ILS
Sbjct: 351 ICFILLILS 359
>XP_005247166
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LCHVLIILS 9
          LC +LIIL+
Sbjct: 7  LCAILIILA 15
>NP_001073909
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LCHVLIILS 9
          LC +LIIL+
Sbjct: 7  LCAILIILA 15
>NP_001004463
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CHVLIILS 9
           C VLI+LS
Sbjct: 209 CFVLIVLS 216
>NP_001004464
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CHVLIILS 9
           C VLI+LS
Sbjct: 209 CFVLIVLS 216
>NP_775869
          Length = 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CHVLII 7
           CH+LII
Sbjct: 427 CHLLII 432
>NP_945344
          Length = 411

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LCHVLII 7
           LCH LI+
Sbjct: 126 LCHQLIV 132
>XP_005257358
          Length = 284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LCHVLII 7
           LCH LI+
Sbjct: 126 LCHQLIV 132
>XP_006719420
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CHVLII 7
           CH+LII
Sbjct: 456 CHLLII 461
>NP_001136336
          Length = 2521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LCHVLIILS 9
            LC+ +IIL+
Sbjct: 1690 LCYFIIILN 1698
>NP_001167594
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LCHVLIILS 9
          LC V IILS
Sbjct: 20 LCAVRIILS 28
>XP_006722587
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LCHVLIILS 9
          LC V IILS
Sbjct: 20 LCAVRIILS 28
>XP_006721417
          Length = 2497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LCHVLIILS 9
            LC+ +IIL+
Sbjct: 1666 LCYFIIILN 1674
>XP_006721416
          Length = 2504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LCHVLIILS 9
            LC+ +IIL+
Sbjct: 1673 LCYFIIILN 1681
>NP_001166031
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 219 LCYLLIVV 226
>NP_001044
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 219 LCYLLIVV 226
>NP_110447
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LCHVLIIL 8
          LC VL++L
Sbjct: 8  LCMVLVLL 15
>NP_001683
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVLIILS 9
           HVL+IL+
Sbjct: 286 HVLVILT 292
>NP_001265616
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 224 LCYLLIVV 231
>NP_001042
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 224 LCYLLIVV 231
>NP_001185951
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 386 CHILI 390
>NP_055526
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 386 CHILI 390
>NP_659403
          Length = 2179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2    CHVLI 6
            CH+LI
Sbjct: 2064 CHILI 2068
>NP_001171175
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 600 CHILI 604
>NP_055211
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCHVLIILS 9
           LC  L++LS
Sbjct: 277 LCDQLVVLS 285
>NP_001684
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVLIILS 9
           HVL+IL+
Sbjct: 292 HVLVILT 298
>XP_005261778
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 224 LCYLLIVV 231
>XP_006724374
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 224 LCYLLIVV 231
>XP_006721168
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 386 CHILI 390
>XP_005255778
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 386 CHILI 390
>XP_005255776
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 386 CHILI 390
>XP_006720999
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LCHVLIIL 8
           LC++LI++
Sbjct: 219 LCYLLIVV 226
>XP_006716792
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 600 CHILI 604
>XP_005251441
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 600 CHILI 604
>XP_005251440
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   CHVLI 6
           CH+LI
Sbjct: 601 CHILI 605
>XP_006716786
          Length = 2179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2    CHVLI 6
            CH+LI
Sbjct: 2064 CHILI 2068
>XP_005251439
          Length = 2179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2    CHVLI 6
            CH+LI
Sbjct: 2064 CHILI 2068
>XP_006715287
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LCHVLIIL 8
          LC VL++L
Sbjct: 8  LCMVLVLL 15
>XP_006715286
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LCHVLIIL 8
          LC VL++L
Sbjct: 8  LCMVLVLL 15
>XP_005264425
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVLIILS 9
           HVL+IL+
Sbjct: 244 HVLVILT 250
>NP_542198
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LCHVLIILS 9
           LC  L++LS
Sbjct: 252 LCDQLVVLS 260
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.349    0.158    0.514 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 531,937
Number of extensions: 784
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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