Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_056507                                                              18    1482
NP_006669                                                              17    4312
NP_653221                                                              17    4312
NP_001243316                                                           17    4312
NP_001243315                                                           17    4312
NP_001243314                                                           17    4312
XP_005270516                                                           17    4312
NP_001265604                                                           16    7355
NP_765975                                                              16    7355
NP_001265598                                                           16    7355
NP_765977                                                              16    7355
NP_765976                                                              16    7355
NP_001265602                                                           16    7355
NP_006153                                                              16    7355
NP_765978                                                              16    7355
NP_001265601                                                           16    7355
NP_001265599                                                           16    7355
NP_004546                                                              16    7355
NP_775186                                                              16    7355
NP_775188                                                              16    7355
NP_060570                                                              16    7355
NP_001165891                                                           16    7355
NP_001070671                                                           16    7355
NP_001269732                                                           16    7355
NP_001269731                                                           16    7355
NP_001269730                                                           16    7355
NP_079216                                                              16    7355
NP_065705                                                              16    7355
NP_835260                                                              16    7355
XP_006722541                                                           16    7355
XP_006722540                                                           16    7355
XP_006716465                                                           16    7355
XP_005273707                                                           16    7355
XP_006714522                                                           16    7355
XP_006714521                                                           16    7355
XP_006714520                                                           16    7355
XP_005248327                                                           16    7355
XP_005248326                                                           16    7355
XP_006714519                                                           16    7355
XP_005247719                                                           16    7355
XP_005270502                                                           16    7355
NP_001108624                                                           16    7355
NP_001002925                                                           16    7355
NP_940908                                                              15    9605
NP_703191                                                              15    9605
NP_001137429                                                           15    9605
NP_110411                                                              15    9605
NP_703190                                                              15    9605
NP_001190192                                                           15    9605
NP_116121                                                              15    9605
XP_006715633                                                           15    9605
XP_006715632                                                           15    9605
XP_006713423                                                           15    9605
XP_006713422                                                           15    9605
XP_006713421                                                           15    9605
XP_006713420                                                           15    9605
XP_006713419                                                           15    9605
XP_006713418                                                           15    9605
XP_006713416                                                           15    9605
XP_006713414                                                           15    9605
XP_006713413                                                           15    9605
XP_006713412                                                           15    9605
XP_006713411                                                           15    9605
XP_006713410                                                           15    9605
XP_006713409                                                           15    9605
>NP_056507
          Length = 1932

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    LAVLEMPLL 9
            +AVLE+PLL
Sbjct: 1618 MAVLEVPLL 1626
>NP_006669
          Length = 224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAVLEMPLL 9
           L +LE+PLL
Sbjct: 187 LVLLELPLL 195
>NP_653221
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LAVLEMPLL 9
           LAVL MP L
Sbjct: 193 LAVLNMPAL 201
>NP_001243316
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LAVLEMPLL 9
           LAVL MP L
Sbjct: 193 LAVLNMPAL 201
>NP_001243315
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LAVLEMPLL 9
           LAVL MP L
Sbjct: 193 LAVLNMPAL 201
>NP_001243314
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LAVLEMPLL 9
           LAVL MP L
Sbjct: 193 LAVLNMPAL 201
>XP_005270516
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LAVLEMPLL 9
           LAVL MP L
Sbjct: 193 LAVLNMPAL 201
>NP_001265604
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 503 VLEIPLL 509
>NP_765975
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 503 VLEIPLL 509
>NP_001265598
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 516 VLEIPLL 522
>NP_765977
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 503 VLEIPLL 509
>NP_765976
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VLEMPLL 9
          VLE+PLL
Sbjct: 44 VLEIPLL 50
>NP_001265602
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VLEMPLL 9
          VLE+PLL
Sbjct: 44 VLEIPLL 50
>NP_006153
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 516 VLEIPLL 522
>NP_765978
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 516 VLEIPLL 522
>NP_001265601
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 503 VLEIPLL 509
>NP_001265599
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 516 VLEIPLL 522
>NP_004546
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 520 VLEIPLL 526
>NP_775186
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 520 VLEIPLL 526
>NP_775188
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 520 VLEIPLL 526
>NP_060570
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAVLEMPL 8
           LAVLE P+
Sbjct: 423 LAVLESPI 430
>NP_001165891
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAVLEMPL 8
           LAVLE P+
Sbjct: 404 LAVLESPI 411
>NP_001070671
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 414 ALLELPLI 421
>NP_001269732
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 315 ALLELPLI 322
>NP_001269731
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 446 ALLELPLI 453
>NP_001269730
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 413 ALLELPLI 420
>NP_079216
          Length = 1870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAVLEMPLL 9
            L  L+MPLL
Sbjct: 1592 LIALQMPLL 1600
>NP_065705
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 479 ALLELPLI 486
>NP_835260
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_006722541
          Length = 639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 516 VLEIPLL 522
>XP_006722540
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLEMPLL 9
           VLE+PLL
Sbjct: 109 VLEIPLL 115
>XP_006716465
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAVLEMPLL 9
            L  L+MPLL
Sbjct: 1592 LIALQMPLL 1600
>XP_005273707
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAVLEMPLL 9
            L  L+MPLL
Sbjct: 1592 LIALQMPLL 1600
>XP_006714522
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_006714521
          Length = 2781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_006714520
          Length = 2802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_005248327
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_005248326
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_006714519
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AVLEMPLL 9
          AVL +PLL
Sbjct: 8  AVLHLPLL 15
>XP_005247719
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           A+LE+PL+
Sbjct: 348 ALLELPLI 355
>XP_005270502
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAVLEMPL 8
           L VLE+PL
Sbjct: 749 LKVLELPL 756
>NP_001108624
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAVLEMPLL 9
           L +LE+PLL
Sbjct: 169 LFLLELPLL 177
>NP_001002925
          Length = 316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAVLEMPLL 9
           +AVL+MP L
Sbjct: 229 IAVLKMPSL 237
>NP_940908
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVLEMPLL 9
           ++L+MPLL
Sbjct: 124 SLLDMPLL 131
>NP_703191
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 426 VLEFPLL 432
>NP_001137429
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LAVLEMP 7
           LAVL MP
Sbjct: 130 LAVLNMP 136
>NP_110411
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LAVLEMP 7
           LAVL MP
Sbjct: 130 LAVLNMP 136
>NP_703190
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 355 VLEFPLL 361
>NP_001190192
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 355 VLEFPLL 361
>NP_116121
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 340 VLEFPLL 346
>XP_006715633
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LAVLEMP 7
           LAVL MP
Sbjct: 130 LAVLNMP 136
>XP_006715632
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LAVLEMP 7
           LAVL MP
Sbjct: 130 LAVLNMP 136
>XP_006713423
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 315 VLEFPLL 321
>XP_006713422
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 327 VLEFPLL 333
>XP_006713421
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 330 VLEFPLL 336
>XP_006713420
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 330 VLEFPLL 336
>XP_006713419
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 340 VLEFPLL 346
>XP_006713418
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 355 VLEFPLL 361
>XP_006713416
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 401 VLEFPLL 407
>XP_006713414
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 411 VLEFPLL 417
>XP_006713413
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 413 VLEFPLL 419
>XP_006713412
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 426 VLEFPLL 432
>XP_006713411
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 413 VLEFPLL 419
>XP_006713410
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 426 VLEFPLL 432
>XP_006713409
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLEMPLL 9
           VLE PLL
Sbjct: 426 VLEFPLL 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.150    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 555,050
Number of extensions: 642
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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