Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001438                                                              19     869
XP_006714824                                                           19     869
NP_005179                                                              18    1935
NP_001276090                                                           17    3301
NP_001276089                                                           17    3301
NP_005922                                                              17    3301
XP_006726158                                                           17    3301
XP_006726065                                                           17    3301
NP_689549                                                              17    4312
NP_000493                                                              17    4312
XP_006722191                                                           17    4312
NP_001180451                                                           16    5631
NP_001180453                                                           16    5631
NP_001180452                                                           16    5631
NP_078795                                                              16    5631
NP_001271286                                                           16    5631
NP_057028                                                              16    5631
NP_001185947                                                           16    5631
NP_001185946                                                           16    5631
NP_001139287                                                           16    5631
NP_060161                                                              16    5631
NP_057655                                                              16    5631
XP_006721333                                                           16    5631
XP_006721332                                                           16    5631
XP_006713999                                                           16    5631
XP_005246782                                                           16    5631
XP_005246780                                                           16    5631
XP_005246776                                                           16    5631
XP_006712723                                                           16    5631
XP_006712722                                                           16    5631
XP_005246775                                                           16    5631
NP_065983                                                              16    7355
NP_002901                                                              15    9605
NP_001159445                                                           15    9605
NP_057311                                                              15    9605
NP_001007526                                                           15    9605
NP_001277284                                                           15    9605
NP_001186623                                                           15    9605
NP_001186622                                                           15    9605
NP_001186621                                                           15    9605
NP_001073341                                                           15    9605
NP_003579                                                              15    9605
NP_003031                                                              15    9605
XP_006724848                                                           15    9605
XP_006724847                                                           15    9605
XP_005262538                                                           15    9605
XP_005269501                                                           15    9605
XP_006716157                                                           15    9605
>NP_001438
          Length = 4349

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LARRTLSHI 9
            LARRTL H+
Sbjct: 1008 LARRTLCHV 1016
>XP_006714824
          Length = 4349

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LARRTLSHI 9
            LARRTL H+
Sbjct: 1008 LARRTLCHV 1016
>NP_005179
          Length = 906

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LARRTLSHI 9
           LARRTLS I
Sbjct: 785 LARRTLSDI 793
>NP_001276090
          Length = 340

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           RRTL+HI
Sbjct: 97  RRTLTHI 103
>NP_001276089
          Length = 351

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RRTLSHI 9
          RRTL+HI
Sbjct: 65 RRTLTHI 71
>NP_005922
          Length = 383

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           RRTL+HI
Sbjct: 97  RRTLTHI 103
>XP_006726158
          Length = 351

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RRTLSHI 9
          RRTL+HI
Sbjct: 65 RRTLTHI 71
>XP_006726065
          Length = 351

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RRTLSHI 9
          RRTL+HI
Sbjct: 65 RRTLTHI 71
>NP_689549
          Length = 1066

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LARRTLSH 8
          LAR+ LSH
Sbjct: 61 LARKNLSH 68
>NP_000493
          Length = 715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ARRTLSH 8
           ARRTL H
Sbjct: 444 ARRTLGH 450
>XP_006722191
          Length = 715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ARRTLSH 8
           ARRTL H
Sbjct: 444 ARRTLGH 450
>NP_001180451
          Length = 1223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 450 RTLSHI 455
>NP_001180453
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 460 RTLSHI 465
>NP_001180452
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 466 RTLSHI 471
>NP_078795
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 446 RTLSHI 451
>NP_001271286
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARRTLSHI 9
           LAR  LSH+
Sbjct: 197 LARNFLSHV 205
>NP_057028
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARRTLSH 8
           +ARR LSH
Sbjct: 94  VARRILSH 101
>NP_001185947
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARRTLSHI 9
           LAR  LSH+
Sbjct: 163 LARNFLSHV 171
>NP_001185946
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARRTLSHI 9
           LAR  LSH+
Sbjct: 212 LARNFLSHV 220
>NP_001139287
          Length = 594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARRTLSH 8
           +ARR LSH
Sbjct: 94  VARRILSH 101
>NP_060161
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARRTLSHI 9
           LAR  LSH+
Sbjct: 207 LARNFLSHV 215
>NP_057655
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LARRTLSHI 9
           +A+R LSH+
Sbjct: 187 IAKRQLSHL 195
>XP_006721333
          Length = 1238

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 466 RTLSHI 471
>XP_006721332
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLSHI 9
           RTLSHI
Sbjct: 466 RTLSHI 471
>XP_006713999
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ARRTLSHI 9
          ARR LSH+
Sbjct: 36 ARRGLSHL 43

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ARRTLSH 8
           ARR LSH
Sbjct: 209 ARRGLSH 215
>XP_005246782
          Length = 732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 690 KRTLSHL 696
>XP_005246780
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 916 KRTLSHL 922
>XP_005246776
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 938 KRTLSHL 944
>XP_006712723
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 938 KRTLSHL 944
>XP_006712722
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 938 KRTLSHL 944
>XP_005246775
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           +RTLSH+
Sbjct: 938 KRTLSHL 944
>NP_065983
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ARRTLSHI 9
           A RTL+H+
Sbjct: 790 AARTLNHV 797
>NP_002901
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARRTLSHI 9
           ARR L H+
Sbjct: 221 ARRILQHV 228
>NP_001159445
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           R+T+SH+
Sbjct: 311 RKTISHL 317
>NP_057311
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LARRTLSHI 9
           +A RT+ HI
Sbjct: 155 IALRTIGHI 163
>NP_001007526
          Length = 1432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARRTLSHI 9
           ARRTLS +
Sbjct: 511 ARRTLSPV 518
>NP_001277284
          Length = 1429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARRTLSHI 9
           ARRTLS +
Sbjct: 376 ARRTLSPV 383
>NP_001186623
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           RRTL+H
Sbjct: 363 RRTLAH 368
>NP_001186622
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           RRTL+H
Sbjct: 368 RRTLAH 373
>NP_001186621
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           RRTL+H
Sbjct: 377 RRTLAH 382
>NP_001073341
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           R+TLSH
Sbjct: 843 RKTLSH 848
>NP_003579
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           R+TLSH
Sbjct: 861 RKTLSH 866
>NP_003031
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           RRTL+H
Sbjct: 377 RRTLAH 382
>XP_006724848
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           R+TLSH
Sbjct: 848 RKTLSH 853
>XP_006724847
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           R+TLSH
Sbjct: 850 RKTLSH 855
>XP_005262538
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           R+TLSH
Sbjct: 863 RKTLSH 868
>XP_005269501
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RRTLSHI 9
           R+T+SH+
Sbjct: 532 RKTISHL 538
>XP_006716157
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRTLSH 8
           RRTL+H
Sbjct: 377 RRTLAH 382
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.137    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 472,823
Number of extensions: 735
Number of successful extensions: 49
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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