Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              19     665
NP_001120972                                                           19     665
XP_006716052                                                           19     665
XP_006716051                                                           19     665
NP_066192                                                              17    3301
NP_060681                                                              17    3301
XP_006710801                                                           17    3301
NP_659489                                                              17    4312
NP_067018                                                              16    7355
NP_055817                                                              16    7355
NP_055285                                                              16    7355
NP_296373                                                              16    7355
NP_077320                                                              15    9605
NP_775110                                                              15    9605
NP_000061                                                              15    9605
NP_001186681                                                           15    9605
NP_001129524                                                           15    9605
NP_689572                                                              15    9605
NP_001186682                                                           15    9605
NP_001136197                                                           15    9605
NP_542394                                                              15    9605
NP_006169                                                              15    9605
XP_006725689                                                           15    9605
XP_006725339                                                           15    9605
XP_006723072                                                           15    9605
XP_005258564                                                           15    9605
XP_005258563                                                           15    9605
XP_005258562                                                           15    9605
XP_006721992                                                           15    9605
>NP_000236
          Length = 1390

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LARQLGASL 9
           LARQ+GASL
Sbjct: 329 LARQIGASL 337
>NP_001120972
          Length = 1408

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LARQLGASL 9
           LARQ+GASL
Sbjct: 329 LARQIGASL 337
>XP_006716052
          Length = 1409

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LARQLGASL 9
           LARQ+GASL
Sbjct: 348 LARQIGASL 356
>XP_006716051
          Length = 1427

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LARQLGASL 9
           LARQ+GASL
Sbjct: 348 LARQIGASL 356
>NP_066192
          Length = 217

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LARQLGASL 9
           L R+LGASL
Sbjct: 156 LKRELGASL 164
>NP_060681
          Length = 678

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L RQLGAS
Sbjct: 204 LGRQLGAS 211
>XP_006710801
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L RQLGAS
Sbjct: 160 LGRQLGAS 167
>NP_659489
          Length = 309

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LARQLGASL 9
           L+RQ+GA L
Sbjct: 102 LSRQIGAQL 110
>NP_067018
          Length = 220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RQLGASL 9
           R+LGASL
Sbjct: 158 RELGASL 164
>NP_055817
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           +ARQLG  L
Sbjct: 311 IARQLGVPL 319
>NP_055285
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LARQLGASL 9
           +A+QLGA +
Sbjct: 155 IAKQLGAEI 163
>NP_296373
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           +ARQLG  L
Sbjct: 311 IARQLGVPL 319
>NP_077320
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RQLGASL 9
           R+LGASL
Sbjct: 493 RKLGASL 499
>NP_775110
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RQLGASL 9
           R+LGASL
Sbjct: 445 RKLGASL 451
>NP_000061
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RQLGASL 9
           R+LGASL
Sbjct: 493 RKLGASL 499
>NP_001186681
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 787 LSRQTGAS 794
>NP_001129524
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 776 LSRQTGAS 783
>NP_689572
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 787 LSRQTGAS 794
>NP_001186682
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 787 LSRQTGAS 794
>NP_001136197
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LARQLG 6
          LARQLG
Sbjct: 6  LARQLG 11
>NP_542394
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LARQLG 6
          LARQLG
Sbjct: 6  LARQLG 11
>NP_006169
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           LARQ+G  L
Sbjct: 269 LARQIGKML 277
>XP_006725689
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           LARQ+G  L
Sbjct: 269 LARQIGKML 277
>XP_006725339
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           LARQ+G  L
Sbjct: 269 LARQIGKML 277
>XP_006723072
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 658 LSRQTGAS 665
>XP_005258564
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 736 LSRQTGAS 743
>XP_005258563
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 787 LSRQTGAS 794
>XP_005258562
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LARQLGAS 8
           L+RQ GAS
Sbjct: 787 LSRQTGAS 794
>XP_006721992
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LARQLGASL 9
           LARQ+G  L
Sbjct: 269 LARQIGKML 277
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.134    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 368,859
Number of extensions: 447
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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