Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001263627                                                           18    1935
NP_001263628                                                           18    1935
NP_001263626                                                           18    1935
NP_064506                                                              15    9605
NP_038464                                                              15    9605
NP_995314                                                              15    9605
NP_001186074                                                           15    9605
NP_001186072                                                           15    9605
NP_001073278                                                           15    9605
XP_006712264                                                           15    9605
XP_006712263                                                           15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 159 AMAIYKQS 166
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 120 AMAIYKQS 127
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 159 AMAIYKQS 166
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 159 AMAIYKQS 166
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 120 AMAIYKQS 127
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 120 AMAIYKQS 127
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 120 AMAIYKQS 127
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 159 AMAIYKQS 166
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AMAIYKQS 9
           AMAIYKQS
Sbjct: 120 AMAIYKQS 127
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  AMAIYKQS 9
          AMAIYKQS
Sbjct: 27 AMAIYKQS 34
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  AMAIYKQS 9
          AMAIYKQS
Sbjct: 27 AMAIYKQS 34
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  AMAIYKQS 9
          AMAIYKQS
Sbjct: 27 AMAIYKQS 34
>NP_001263627
          Length = 182

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3 MAIYKQS 9
         MAIYKQS
Sbjct: 1 MAIYKQS 7
>NP_001263628
          Length = 187

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3 MAIYKQS 9
         MAIYKQS
Sbjct: 1 MAIYKQS 7
>NP_001263626
          Length = 234

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3 MAIYKQS 9
         MAIYKQS
Sbjct: 1 MAIYKQS 7
>NP_064506
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MAIYKQS 9
          +AIYKQ+
Sbjct: 74 LAIYKQT 80
>NP_038464
          Length = 1128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    AIYKQS 9
            A+YKQS
Sbjct: 1118 AVYKQS 1123
>NP_995314
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    AIYKQS 9
            A+YKQS
Sbjct: 1124 AVYKQS 1129
>NP_001186074
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAMAIYKQS 9
           LAMA+ KQ+
Sbjct: 554 LAMALKKQT 562
>NP_001186072
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAMAIYKQS 9
           LAMA+ KQ+
Sbjct: 809 LAMALKKQT 817
>NP_001073278
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAMAIYKQS 9
           LAMA+ KQ+
Sbjct: 776 LAMALKKQT 784
>XP_006712264
          Length = 1126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    AIYKQS 9
            A+YKQS
Sbjct: 1116 AVYKQS 1121
>XP_006712263
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    AIYKQS 9
            A+YKQS
Sbjct: 1122 AVYKQS 1127
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.124    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 296,996
Number of extensions: 197
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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