Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              19     665
XP_005268094                                                           19     665
XP_006716440                                                           17    4312
NP_444504                                                              16    7355
XP_005267162                                                           16    7355
XP_005267161                                                           16    7355
XP_005267159                                                           16    7355
XP_006710372                                                           16    7355
XP_005270458                                                           16    7355
XP_005270457                                                           16    7355
NP_001036014                                                           16    7355
NP_775789                                                              15    9605
NP_001275675                                                           15    9605
NP_065937                                                              15    9605
XP_005267361                                                           15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_006717589                                                           15    9605
XP_006717588                                                           15    9605
XP_006717587                                                           15    9605
XP_006717586                                                           15    9605
XP_006717585                                                           15    9605
XP_006717584                                                           15    9605
XP_006716496                                                           15    9605
XP_006716495                                                           15    9605
XP_005251231                                                           15    9605
XP_006716493                                                           15    9605
XP_006716492                                                           15    9605
XP_006716491                                                           15    9605
XP_006716490                                                           15    9605
NP_001129632                                                           15    9605
NP_071387                                                              15    9605
NP_001032365                                                           15    9605
NP_612469                                                              15    9605
>NP_000360
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LALSYIVFV 9
           LAL+YIVFV
Sbjct: 578 LALAYIVFV 586
>XP_005268094
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LALSYIVFV 9
           LAL+YIVFV
Sbjct: 578 LALAYIVFV 586
>XP_006716440
          Length = 171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALSYIVFV 9
           A+SYI+F+
Sbjct: 156 AMSYIIFL 163
>NP_444504
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALSYIVFV 9
           +L+Y+VFV
Sbjct: 288 SLAYLVFV 295
>XP_005267162
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ALSYIVF 8
           ALSY VF
Sbjct: 380 ALSYFVF 386
>XP_005267161
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ALSYIVF 8
           ALSY VF
Sbjct: 380 ALSYFVF 386
>XP_005267159
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ALSYIVF 8
           ALSY VF
Sbjct: 572 ALSYFVF 578
>XP_006710372
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALSYIVFV 9
           +L+Y+VFV
Sbjct: 121 SLAYLVFV 128
>XP_005270458
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALSYIVFV 9
           +L+Y+VFV
Sbjct: 246 SLAYLVFV 253
>XP_005270457
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALSYIVFV 9
           +L+Y+VFV
Sbjct: 288 SLAYLVFV 295
>NP_001036014
          Length = 213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LSYIVFV 9
           LSY+VF+
Sbjct: 186 LSYMVFI 192
>NP_775789
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>NP_001275675
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LALSYIVFV 9
          LAL+ I+F+
Sbjct: 42 LALTLIIFI 50
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 917 ALSYLVY 923
>XP_005267361
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LALSYIVFV 9
          LAL+ I+F+
Sbjct: 42 LALTLIIFI 50
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 760 ALSYLVY 766
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 885 ALSYLVY 891
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 886 ALSYLVY 892
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 918 ALSYLVY 924
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 920 ALSYLVY 926
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 958 ALSYLVY 964
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 977 ALSYLVY 983
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 979 ALSYLVY 985
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALSYIVF 8
           ALSY+V+
Sbjct: 980 ALSYLVY 986
>XP_006717589
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006717588
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006717587
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006717586
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006717585
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006717584
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALSYIVFV 9
           L  +YIVFV
Sbjct: 171 LECTYIVFV 179
>XP_006716496
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 344 ALKYLVFL 351
>XP_006716495
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 344 ALKYLVFL 351
>XP_005251231
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 523 ALKYLVFL 530
>XP_006716493
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>XP_006716492
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 559 ALKYLVFL 566
>XP_006716491
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 566 ALKYLVFL 573
>XP_006716490
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 568 ALKYLVFL 575
>NP_001129632
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ALSYIVFV 9
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>NP_071387
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LSYIVFV 9
           LS+IVF+
Sbjct: 579 LSFIVFI 585
>NP_001032365
          Length = 125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LALSYIVFV 9
          LAL+ I+F+
Sbjct: 42 LALTLIIFI 50
>NP_612469
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LALSYIVFV 9
          LAL+ I+F+
Sbjct: 42 LALTLIIFI 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.157    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 357,750
Number of extensions: 437
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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