Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_001258934                                                           16    5631
NP_055891                                                              16    5631
NP_001243064                                                           16    5631
NP_057323                                                              16    5631
NP_839947                                                              16    5631
NP_001307                                                              16    5631
XP_005256732                                                           16    5631
XP_005266930                                                           16    5631
XP_006715465                                                           16    5631
NP_653264                                                              16    5631
NP_003259                                                              16    7355
XP_006720661                                                           16    7355
XP_006720660                                                           16    7355
XP_006711570                                                           16    7355
XP_006711569                                                           16    7355
XP_006711568                                                           16    7355
XP_005273300                                                           16    7355
XP_006711567                                                           16    7355
XP_006711566                                                           16    7355
XP_005273298                                                           16    7355
XP_005273299                                                           16    7355
NP_001181927                                                           15    9605
NP_055800                                                              15    9605
NP_001080                                                              15    9605
NP_003958                                                              15    9605
NP_037496                                                              15    9605
NP_001269464                                                           15    9605
NP_569057                                                              15    9605
NP_056328                                                              15    9605
NP_001273387                                                           15    9605
NP_071737                                                              15    9605
NP_066022                                                              15    9605
NP_003461                                                              15    9605
NP_878905                                                              15    9605
NP_001273386                                                           15    9605
XP_006723369                                                           15    9605
XP_006722421                                                           15    9605
XP_006720500                                                           15    9605
XP_005265446                                                           15    9605
XP_005265445                                                           15    9605
NP_001070883                                                           15    9605
NP_001128350                                                           15    9605
NP_542401                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            LALQQVFL
Sbjct: 3028 LALQQVFL 3035
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            LALQQVFL
Sbjct: 3020 LALQQVFL 3027
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            LALQQVFL
Sbjct: 2981 LALQQVFL 2988
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            LALQQVFL
Sbjct: 3060 LALQQVFL 3067
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            LALQQVFL
Sbjct: 3073 LALQQVFL 3080
>NP_001258934
          Length = 578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LALQQVFLG 9
          LAL  VFLG
Sbjct: 76 LALNVVFLG 84
>NP_055891
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LALQQVFL 8
          +ALQ+VFL
Sbjct: 79 IALQKVFL 86
>NP_001243064
          Length = 915

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALQQVFLG 9
           LALQ++F G
Sbjct: 748 LALQEIFDG 756
>NP_057323
          Length = 3530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALQQVFL 8
            LALQQ F+
Sbjct: 2451 LALQQAFI 2458
>NP_839947
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALQQVFLG 9
           LAL  VFLG
Sbjct: 94  LALNVVFLG 102
>NP_001307
          Length = 971

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALQQVFLG 9
           LALQ++F G
Sbjct: 804 LALQEIFDG 812
>XP_005256732
          Length = 3531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALQQVFL 8
            LALQQ F+
Sbjct: 2452 LALQQAFI 2459
>XP_005266930
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LALQQVFL 8
          +ALQ+VFL
Sbjct: 79 IALQKVFL 86
>XP_006715465
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LALQQVFL 8
          +ALQ+VFL
Sbjct: 19 IALQKVFL 26
>NP_653264
          Length = 217

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALQQVFLG 9
           LAL QVF G
Sbjct: 189 LALLQVFAG 197
>NP_003259
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_006720661
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LQQVFLG 9
           +QQ+FLG
Sbjct: 510 MQQLFLG 516
>XP_006720660
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LQQVFLG 9
           +QQ+FLG
Sbjct: 510 MQQLFLG 516
>XP_006711570
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_006711569
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_006711568
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_005273300
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_006711567
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_006711566
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_005273298
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>XP_005273299
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALQQVFLG 9
           +L+Q+FLG
Sbjct: 474 SLEQLFLG 481
>NP_001181927
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LQQVFLG 9
           LQQ FLG
Sbjct: 221 LQQQFLG 227
>NP_055800
          Length = 1654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LQQVFLG 9
           LQQ FLG
Sbjct: 221 LQQQFLG 227
>NP_001080
          Length = 1704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LALQQVFL 8
            ++L+QVFL
Sbjct: 1683 ISLEQVFL 1690
>NP_003958
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LALQQVFLG 9
          LAL  +FLG
Sbjct: 76 LALADMFLG 84
>NP_037496
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 235 ALQQVF 240
>NP_001269464
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 235 ALQQVF 240
>NP_569057
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQQVFL 8
           LQQVFL
Sbjct: 244 LQQVFL 249
>NP_056328
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LALQQVFLG 9
           + LQQ+F G
Sbjct: 364 VVLQQMFFG 372
>NP_001273387
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LALQQVF 7
           LALQ+VF
Sbjct: 159 LALQRVF 165
>NP_071737
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 119 ALQQVF 124
>NP_066022
          Length = 2564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LALQQVF 7
           LALQ+VF
Sbjct: 535 LALQKVF 541
>NP_003461
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LALQQVF 7
           LALQ+VF
Sbjct: 258 LALQRVF 264
>NP_878905
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 119 ALQQVF 124
>NP_001273386
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LALQQVF 7
           LALQ+VF
Sbjct: 242 LALQRVF 248
>XP_006723369
          Length = 2394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LALQQVF 7
           LALQ+VF
Sbjct: 535 LALQKVF 541
>XP_006722421
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LQQVFL 8
           LQQVFL
Sbjct: 244 LQQVFL 249
>XP_006720500
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LQQVFLG 9
           LQQ FLG
Sbjct: 221 LQQQFLG 227
>XP_005265446
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 152 ALQQVF 157
>XP_005265445
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 152 ALQQVF 157
>NP_001070883
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LALQQVFLG 9
           + LQQ+F G
Sbjct: 364 VVLQQMFFG 372
>NP_001128350
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALQQVF 7
           ALQQVF
Sbjct: 119 ALQQVF 124
>NP_542401
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LALQQVFL 8
           LALQ +FL
Sbjct: 217 LALQNLFL 224
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.152    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 379,145
Number of extensions: 543
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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