Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_001129246                                                           17    4312
NP_003481                                                              17    4312
NP_598344                                                              17    4312
NP_001269633                                                           16    5631
NP_001269634                                                           16    5631
NP_001269635                                                           16    5631
NP_005733                                                              16    5631
NP_001269636                                                           16    5631
XP_005246202                                                           16    5631
XP_006711919                                                           16    5631
NP_001026                                                              16    7355
NP_065140                                                              16    7355
NP_001243325                                                           16    7355
NP_001243324                                                           16    7355
NP_116231                                                              16    7355
NP_112592                                                              16    7355
XP_005269228                                                           16    7355
XP_005250714                                                           16    7355
XP_005250712                                                           16    7355
XP_006711873                                                           16    7355
XP_006711872                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
NP_055178                                                              15    9605
NP_001264984                                                           15    9605
NP_640337                                                              15    9605
NP_001121187                                                           15    9605
NP_055851                                                              15    9605
NP_001004754                                                           15    9605
NP_004843                                                              15    9605
NP_003578                                                              15    9605
NP_055214                                                              15    9605
NP_001157711                                                           15    9605
XP_005266395                                                           15    9605
XP_006715402                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALNSLYS 8
            LALNSLYS
Sbjct: 2540 LALNSLYS 2547
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LALNSLYS 8
            LALNSLYS
Sbjct: 2540 LALNSLYS 2547
>NP_001129246
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALNSLYSL 9
           A+NSLYS+
Sbjct: 190 AVNSLYSV 197
>NP_003481
          Length = 580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALNSLYSL 9
           A+NSLYS+
Sbjct: 191 AVNSLYSV 198
>NP_598344
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALNSLYSL 9
           A+NSLYS+
Sbjct: 191 AVNSLYSV 198
>NP_001269633
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 67 LAVNGLYS 74
>NP_001269634
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 63 LAVNGLYS 70
>NP_001269635
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 20 LAVNGLYS 27
>NP_005733
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 15 LAVNGLYS 22
>NP_001269636
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 12 LAVNGLYS 19
>XP_005246202
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 15 LAVNGLYS 22
>XP_006711919
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LALNSLYS 8
          LA+N LYS
Sbjct: 15 LAVNGLYS 22
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>NP_065140
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALNSLYSL 9
           ALN+ YSL
Sbjct: 251 ALNTYYSL 258
>NP_001243325
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALNSLYSL 9
           ALN+ YSL
Sbjct: 221 ALNTYYSL 228
>NP_001243324
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALNSLYSL 9
           ALN+ YSL
Sbjct: 182 ALNTYYSL 189
>NP_116231
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LALNSLYSL 9
          LAL SL+SL
Sbjct: 68 LALASLFSL 76
>NP_112592
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ALNSLYS 8
          A+NS+YS
Sbjct: 68 AINSIYS 74
>XP_005269228
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ALNSLYS 8
          A+NS+YS
Sbjct: 68 AINSIYS 74
>XP_005250714
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LALNSLYSL 9
          LAL SL+SL
Sbjct: 68 LALASLFSL 76
>XP_005250712
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LALNSLYSL 9
          LAL SL+SL
Sbjct: 67 LALASLFSL 75
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711872
          Length = 2735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSLYSL 9
           LNSLY L
Sbjct: 530 LNSLYEL 536
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ALNSLYSL 9
            ALN LYS+
Sbjct: 2758 ALNVLYSV 2765
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ALNSLYSL 9
            ALN LYS+
Sbjct: 2611 ALNVLYSV 2618
>NP_640337
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALNSLYSL 9
           LA+NS Y L
Sbjct: 635 LAVNSSYGL 643
>NP_001121187
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALNSLYSL 9
           LA+NS Y L
Sbjct: 635 LAVNSSYGL 643
>NP_055851
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LALNSLYSL 9
          LAL SL++L
Sbjct: 7  LALGSLFAL 15
>NP_001004754
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LALNSLYSL 9
           +++NS+Y L
Sbjct: 192 ISINSIYGL 200
>NP_004843
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ALNSLYS 8
           A+N+LYS
Sbjct: 206 AMNNLYS 212
>NP_003578
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALNSLYSL 9
           LAL  LY+L
Sbjct: 791 LALEQLYAL 799
>NP_055214
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALNSLYSL 9
          ALN LY+L
Sbjct: 15 ALNLLYTL 22
>NP_001157711
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALNSLYSL 9
           LAL  LY+L
Sbjct: 731 LALEQLYAL 739
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ALNSLYSL 9
            ALN LYS+
Sbjct: 2767 ALNVLYSV 2774
>XP_006715402
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LALNSLYSL 9
           LA+NS Y L
Sbjct: 635 LAVNSSYGL 643
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.133    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,846
Number of extensions: 574
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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