Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              18    1135
XP_005268094                                                           18    1135
XP_005250044                                                           18    1935
XP_005250043                                                           18    1935
NP_001001802                                                           18    1935
NP_001005287                                                           18    1935
NP_000483                                                              17    3301
XP_006715905                                                           17    3301
NP_036497                                                              16    5631
NP_002238                                                              16    7355
NP_001258448                                                           16    7355
NP_001154825                                                           16    7355
NP_001258447                                                           16    7355
NP_001154824                                                           16    7355
NP_001014797                                                           16    7355
NP_055994                                                              16    7355
NP_001138586                                                           16    7355
NP_005472                                                              16    7355
NP_001271266                                                           16    7355
XP_006722663                                                           16    7355
XP_005269842                                                           16    7355
XP_005269838                                                           16    7355
XP_005269835                                                           16    7355
XP_005269837                                                           16    7355
XP_006717893                                                           16    7355
XP_005269844                                                           16    7355
XP_005269833                                                           16    7355
XP_006717891                                                           16    7355
XP_006717890                                                           16    7355
XP_005269854                                                           16    7355
XP_005269853                                                           16    7355
XP_005269852                                                           16    7355
XP_006717889                                                           16    7355
XP_005269849                                                           16    7355
XP_005269846                                                           16    7355
XP_006717888                                                           16    7355
XP_006717887                                                           16    7355
XP_006717886                                                           16    7355
XP_006717885                                                           16    7355
XP_006717884                                                           16    7355
XP_005269836                                                           16    7355
NP_996776                                                              16    7355
NP_001139623                                                           15    9605
NP_000045                                                              15    9605
NP_000184                                                              15    9605
NP_001026794                                                           15    9605
NP_057063                                                              15    9605
NP_001139129                                                           15    9605
NP_612382                                                              15    9605
NP_001018655                                                           15    9605
NP_001277117                                                           15    9605
NP_001277118                                                           15    9605
NP_001018656                                                           15    9605
NP_001277121                                                           15    9605
NP_001277120                                                           15    9605
NP_001277123                                                           15    9605
NP_001018657                                                           15    9605
NP_001277122                                                           15    9605
NP_001277119                                                           15    9605
NP_001018654                                                           15    9605
NP_004821                                                              15    9605
NP_001257451                                                           15    9605
NP_001257450                                                           15    9605
NP_001139130                                                           15    9605
NP_002876                                                              15    9605
XP_006724891                                                           15    9605
XP_005267280                                                           15    9605
XP_005249051                                                           15    9605
XP_006710870                                                           15    9605
XP_005246013                                                           15    9605
XP_006710869                                                           15    9605
XP_005246012                                                           15    9605
XP_005246011                                                           15    9605
XP_006710868                                                           15    9605
XP_006710867                                                           15    9605
>NP_000360
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LALAHIVFV 9
           LALA+IVFV
Sbjct: 578 LALAYIVFV 586
>XP_005268094
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LALAHIVFV 9
           LALA+IVFV
Sbjct: 578 LALAYIVFV 586
>XP_005250044
          Length = 310

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH+V +
Sbjct: 154 LALAHVVLI 162
>XP_005250043
          Length = 329

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH+V +
Sbjct: 173 LALAHVVLI 181
>NP_001001802
          Length = 310

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH+V +
Sbjct: 154 LALAHVVLI 162
>NP_001005287
          Length = 310

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH+V +
Sbjct: 154 LALAHVVLI 162
>NP_000483
          Length = 1480

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH V++
Sbjct: 195 LALAHFVWI 203
>XP_006715905
          Length = 1588

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LALAH V++
Sbjct: 303 LALAHFVWI 311
>NP_036497
          Length = 311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LALAHIVFV 9
           LAL H+V +
Sbjct: 155 LALVHVVLI 163
>NP_002238
          Length = 1178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>NP_001258448
          Length = 1208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 819 LKHIVFV 825
>NP_001154825
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 857 LKHIVFV 863
>NP_001258447
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 766 LKHIVFV 772
>NP_001154824
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 874 LKHIVFV 880
>NP_001014797
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 820 LKHIVFV 826
>NP_055994
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LALAHIVF 8
           LAL H++F
Sbjct: 922 LALTHLLF 929
>NP_001138586
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LALAHIVF 8
           LAL H++F
Sbjct: 861 LALTHLLF 868
>NP_005472
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LAL H++F+
Sbjct: 469 LALRHLLFL 477
>NP_001271266
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LALAHIVF 8
           LAL H++F
Sbjct: 822 LALTHLLF 829
>XP_006722663
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LALAHIVFV 9
           LAL H++F+
Sbjct: 469 LALRHLLFL 477
>XP_005269842
          Length = 1234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 820 LKHIVFV 826
>XP_005269838
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 874 LKHIVFV 880
>XP_005269835
          Length = 1239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 878 LKHIVFV 884
>XP_005269837
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 881 LKHIVFV 887
>XP_006717893
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 845 LKHIVFV 851
>XP_005269844
          Length = 1230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>XP_005269833
          Length = 1257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>XP_006717891
          Length = 1143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 754 LKHIVFV 760
>XP_006717890
          Length = 1145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 756 LKHIVFV 762
>XP_005269854
          Length = 1177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>XP_005269853
          Length = 1178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>XP_005269852
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 820 LKHIVFV 826
>XP_006717889
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 816 LKHIVFV 822
>XP_005269849
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 845 LKHIVFV 851
>XP_005269846
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 820 LKHIVFV 826
>XP_006717888
          Length = 1210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 849 LKHIVFV 855
>XP_006717887
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 849 LKHIVFV 855
>XP_006717886
          Length = 1234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 845 LKHIVFV 851
>XP_006717885
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 849 LKHIVFV 855
>XP_006717884
          Length = 1238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 849 LKHIVFV 855
>XP_005269836
          Length = 1238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           L HIVFV
Sbjct: 849 LKHIVFV 855
>NP_996776
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LALAHIVF 8
          +AL H+VF
Sbjct: 67 IALLHLVF 74
>NP_001139623
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LALAHIVFV 9
          LAL  IVFV
Sbjct: 41 LALLSIVFV 49
>NP_000045
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LALAHIVFV 9
          LAL  IVFV
Sbjct: 41 LALLSIVFV 49
>NP_000184
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LALAHIVFV 9
           L  AH++FV
Sbjct: 266 LTAAHLLFV 274
>NP_001026794
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           + HIVFV
Sbjct: 885 MTHIVFV 891
>NP_057063
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALAHIVF 8
            LALAH V+
Sbjct: 1215 LALAHAVW 1222
>NP_001139129
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 108 ALGHLVF 114
>NP_612382
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001018655
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277117
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277118
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001018656
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277121
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277120
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277123
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001018657
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277122
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001277119
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_001018654
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AHIVFV 9
           AH+VFV
Sbjct: 315 AHLVFV 320
>NP_004821
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALAHIVF 8
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001257451
          Length = 1364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALAHIVF 8
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001257450
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALAHIVF 8
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001139130
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 172 ALGHLVF 178
>NP_002876
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 108 ALGHLVF 114
>XP_006724891
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LALAHIVFV 9
          LAL  IVFV
Sbjct: 41 LALLSIVFV 49
>XP_005267280
          Length = 1374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LALAHIVF 8
            LALAH V+
Sbjct: 1215 LALAHAVW 1222
>XP_005249051
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LAHIVFV 9
           + HIVFV
Sbjct: 885 MTHIVFV 891
>XP_006710870
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 139 ALGHLVF 145
>XP_005246013
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710869
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 172 ALGHLVF 178
>XP_005246012
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_005246011
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710868
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710867
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ALAHIVF 8
           AL H+VF
Sbjct: 245 ALGHLVF 251
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.353    0.155    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,027
Number of extensions: 575
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package