Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_000479                                                              17    2528
XP_005245255                                                           17    2528
NP_004949                                                              17    4312
NP_219499                                                              17    4312
NP_056541                                                              17    4312
XP_005250692                                                           17    4312
XP_005250691                                                           17    4312
XP_005263496                                                           17    4312
XP_005263495                                                           17    4312
NP_008835                                                              16    5631
NP_001075109                                                           16    5631
NP_001106954                                                           16    5631
NP_001026910                                                           16    5631
NP_689943                                                              16    5631
XP_005266918                                                           16    5631
NP_149043                                                              16    7355
NP_001171588                                                           16    7355
NP_115492                                                              16    7355
NP_004888                                                              16    7355
NP_076917                                                              16    7355
NP_003889                                                              16    7355
NP_001014402                                                           16    7355
NP_008922                                                              16    7355
NP_008999                                                              16    7355
NP_001265137                                                           16    7355
NP_001020026                                                           16    7355
XP_006724176                                                           16    7355
XP_006724175                                                           16    7355
XP_006724174                                                           16    7355
XP_006724173                                                           16    7355
XP_005266631                                                           16    7355
XP_006718141                                                           16    7355
XP_006715655                                                           16    7355
XP_006715654                                                           16    7355
XP_005264840                                                           16    7355
NP_055724                                                              15    9605
NP_055692                                                              15    9605
NP_997190                                                              15    9605
XP_003403541                                                           15    9605
XP_005257947                                                           15    9605
XP_005257946                                                           15    9605
XP_005257945                                                           15    9605
XP_006722277                                                           15    9605
XP_005247947                                                           15    9605
XP_006713884                                                           15    9605
XP_006713883                                                           15    9605
XP_003846688                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2715 LVKGRDDLR 2723
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 1367 LVKGRDDLR 1375
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2367 LVKGRDDLR 2375
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2709 LVKGRDDLR 2717
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2715 LVKGRDDLR 2723
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2715 LVKGRDDLR 2723
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LAKGRDDLR 9
            L KGRDDLR
Sbjct: 2715 LVKGRDDLR 2723
>NP_000479
          Length = 464

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LAKGRDDL 8
           +A+GRDDL
Sbjct: 387 VAEGRDDL 394
>XP_005245255
          Length = 416

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LAKGRDDL 8
           +A+GRDDL
Sbjct: 339 VAEGRDDL 346
>NP_004949
          Length = 2549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            L KG +DLR
Sbjct: 2185 LLKGHEDLR 2193
>NP_219499
          Length = 1663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            +A  RDDLR
Sbjct: 1549 IADSRDDLR 1557
>NP_056541
          Length = 597

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           LA G DDL+
Sbjct: 208 LASGSDDLK 216
>XP_005250692
          Length = 964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           +A  RDDLR
Sbjct: 850 IADSRDDLR 858
>XP_005250691
          Length = 1645

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            +A  RDDLR
Sbjct: 1531 IADSRDDLR 1539
>XP_005263496
          Length = 2322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            L KG +DLR
Sbjct: 1958 LLKGHEDLR 1966
>XP_005263495
          Length = 2549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            L KG +DLR
Sbjct: 2185 LLKGHEDLR 2193
>NP_008835
          Length = 4128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            L KG +DLR
Sbjct: 3751 LVKGGEDLR 3759
>NP_001075109
          Length = 4097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LAKGRDDLR 9
            L KG +DLR
Sbjct: 3751 LVKGGEDLR 3759
>NP_001106954
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KGRDDL 8
           KGRDD+
Sbjct: 229 KGRDDI 234
>NP_001026910
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KGRDDL 8
           KGRDD+
Sbjct: 229 KGRDDI 234
>NP_689943
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L  GRDD+R
Sbjct: 762 LEYGRDDVR 770
>XP_005266918
          Length = 1298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L  GRDD+R
Sbjct: 762 LEYGRDDVR 770
>NP_149043
          Length = 1018

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AKGRDDL 8
           A+G+DDL
Sbjct: 933 ARGQDDL 939
>NP_001171588
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KGRDDLR 9
           KGR D+R
Sbjct: 149 KGRQDMR 155
>NP_115492
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AKGRDD 7
           A+GRDD
Sbjct: 158 ARGRDD 163
>NP_004888
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KGRDDLR 9
           KGR D+R
Sbjct: 149 KGRQDMR 155
>NP_076917
          Length = 357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GRDDLR 9
          G+DDLR
Sbjct: 25 GKDDLR 30
>NP_003889
          Length = 1496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AKGRDD 7
          A+GRDD
Sbjct: 25 ARGRDD 30
>NP_001014402
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AKGRDD 7
           A+GRDD
Sbjct: 158 ARGRDD 163
>NP_008922
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LAKGRDD 7
          L KG+DD
Sbjct: 16 LVKGKDD 22
>NP_008999
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 303 LRKGRGELR 311
>NP_001265137
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 248 LRKGRGELR 256
>NP_001020026
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LAKGRDD 7
          L KG+DD
Sbjct: 16 LVKGKDD 22
>XP_006724176
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 234 LRKGRGELR 242
>XP_006724175
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 248 LRKGRGELR 256
>XP_006724174
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 289 LRKGRGELR 297
>XP_006724173
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           L KGR +LR
Sbjct: 303 LRKGRGELR 311
>XP_005266631
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AKGRDD 7
           A+GRDD
Sbjct: 158 ARGRDD 163
>XP_006718141
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KGRDDLR 9
           KGR D+R
Sbjct: 149 KGRQDMR 155
>XP_006715655
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AKGRDD 7
          A+GRDD
Sbjct: 25 ARGRDD 30
>XP_006715654
          Length = 1495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AKGRDD 7
          A+GRDD
Sbjct: 25 ARGRDD 30
>XP_005264840
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LAKGRDD 7
          L KG+DD
Sbjct: 16 LVKGKDD 22
>NP_055724
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRDDLR 9
           GRDD R
Sbjct: 286 GRDDFR 291
>NP_055692
          Length = 1942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LAKGRDDLR 9
          LAKG D  R
Sbjct: 88 LAKGEDAFR 96
>NP_997190
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           LAK RD L+
Sbjct: 283 LAKHRDSLK 291
>XP_003403541
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LAKGRDD 7
          LAK RDD
Sbjct: 49 LAKERDD 55
>XP_005257947
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LAKGRDDLR 9
          LAKG D  R
Sbjct: 88 LAKGEDAFR 96
>XP_005257946
          Length = 1943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LAKGRDDLR 9
          LAKG D  R
Sbjct: 88 LAKGEDAFR 96
>XP_005257945
          Length = 1969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LAKGRDDLR 9
          LAKG D  R
Sbjct: 88 LAKGEDAFR 96
>XP_006722277
          Length = 1970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LAKGRDDLR 9
          LAKG D  R
Sbjct: 88 LAKGEDAFR 96
>XP_005247947
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           LAK RD L+
Sbjct: 283 LAKHRDSLK 291
>XP_006713884
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           LAK RD L+
Sbjct: 283 LAKHRDSLK 291
>XP_006713883
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKGRDDLR 9
           LAK RD L+
Sbjct: 283 LAKHRDSLK 291
>XP_003846688
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LAKGRDD 7
          LAK RDD
Sbjct: 49 LAKERDD 55
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.147    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 647,053
Number of extensions: 990
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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