Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              22      79
NP_002871                                                              22      79
XP_005250103                                                           22      79
XP_005250102                                                           22      79
XP_005265417                                                           22      79
XP_005265416                                                           22      79
XP_005265415                                                           22      79
XP_005265414                                                           22      79
XP_005265412                                                           22      79
NP_001243125                                                           20     299
NP_001645                                                              20     299
XP_006724592                                                           20     299
NP_001007467                                                           18    1135
NP_064630                                                              18    1135
XP_005267114                                                           18    1135
NP_001011718                                                           17    3301
NP_001129122                                                           17    4312
NP_004271                                                              17    4312
NP_001138508                                                           16    5631
NP_031383                                                              16    5631
XP_005253387                                                           16    5631
XP_006719103                                                           16    5631
XP_005253383                                                           16    5631
NP_001156909                                                           16    7355
NP_149106                                                              16    7355
NP_001156908                                                           16    7355
NP_001156907                                                           16    7355
NP_775871                                                              16    7355
XP_005259087                                                           16    7355
XP_006723320                                                           16    7355
XP_005259086                                                           16    7355
XP_006723319                                                           16    7355
XP_005259085                                                           16    7355
XP_006714482                                                           16    7355
NP_060498                                                              16    7355
NP_001277482                                                           15    9605
NP_001277486                                                           15    9605
NP_001277558                                                           15    9605
NP_057083                                                              15    9605
NP_001127923                                                           15    9605
NP_001127922                                                           15    9605
NP_690877                                                              15    9605
NP_077283                                                              15    9605
XP_006726390                                                           15    9605
XP_006726389                                                           15    9605
XP_006726388                                                           15    9605
XP_006726387                                                           15    9605
XP_006711142                                                           15    9605
XP_006711141                                                           15    9605
XP_006711140                                                           15    9605
XP_006710131                                                           15    9605
XP_006710130                                                           15    9605
XP_006710129                                                           15    9605
XP_006710128                                                           15    9605
>NP_004324
          Length = 766

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 525 LAIVTQWCE 533
>NP_002871
          Length = 648

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 417 LAIVTQWCE 425
>XP_005250103
          Length = 758

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 525 LAIVTQWCE 533
>XP_005250102
          Length = 767

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 525 LAIVTQWCE 533
>XP_005265417
          Length = 494

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 417 LAIVTQWCE 425
>XP_005265416
          Length = 534

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 303 LAIVTQWCE 311
>XP_005265415
          Length = 567

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 336 LAIVTQWCE 344
>XP_005265414
          Length = 615

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 384 LAIVTQWCE 392
>XP_005265412
          Length = 648

 Score = 22.3 bits (46), Expect =    79
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAIVAQWCE 9
           LAIV QWCE
Sbjct: 417 LAIVTQWCE 425
>NP_001243125
          Length = 609

 Score = 20.4 bits (41), Expect =   299
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIVAQWCE 9
           AI+ QWCE
Sbjct: 382 AIITQWCE 389
>NP_001645
          Length = 606

 Score = 20.4 bits (41), Expect =   299
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIVAQWCE 9
           AI+ QWCE
Sbjct: 379 AIITQWCE 386
>XP_006724592
          Length = 611

 Score = 20.4 bits (41), Expect =   299
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIVAQWCE 9
           AI+ QWCE
Sbjct: 384 AIITQWCE 391
>NP_001007467
          Length = 678

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IVAQWC 8
           +VAQWC
Sbjct: 288 VVAQWC 293
>NP_064630
          Length = 1543

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IVAQWC 8
           +VAQWC
Sbjct: 288 VVAQWC 293
>XP_005267114
          Length = 1543

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IVAQWC 8
           +VAQWC
Sbjct: 288 VVAQWC 293
>NP_001011718
          Length = 579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   IVAQWC 8
           IVA WC
Sbjct: 332 IVAHWC 337
>NP_001129122
          Length = 139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  AIVAQWCE 9
          AIV QW E
Sbjct: 69 AIVQQWLE 76
>NP_004271
          Length = 174

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  AIVAQWCE 9
          AIV QW E
Sbjct: 69 AIVQQWLE 76
>NP_001138508
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AIVAQWCE 9
           AI+ QW E
Sbjct: 628 AIIQQWLE 635
>NP_031383
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AIVAQWCE 9
           AI+ QW E
Sbjct: 629 AIIQQWLE 636
>XP_005253387
          Length = 1156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          LA++ QW E
Sbjct: 41 LAVLYQWLE 49
>XP_006719103
          Length = 1296

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          LA++ QW E
Sbjct: 41 LAVLYQWLE 49
>XP_005253383
          Length = 1333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          LA++ QW E
Sbjct: 41 LAVLYQWLE 49
>NP_001156909
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          L +VA+ CE
Sbjct: 67 LVVVAEHCE 75
>NP_149106
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          L +VA+ CE
Sbjct: 67 LVVVAEHCE 75
>NP_001156908
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          L +VA+ CE
Sbjct: 67 LVVVAEHCE 75
>NP_001156907
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          L +VA+ CE
Sbjct: 67 LVVVAEHCE 75
>NP_775871
          Length = 8384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3  IVAQWC 8
          +VA WC
Sbjct: 9  VVALWC 14
>XP_005259087
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006723320
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_005259086
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006723319
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_005259085
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>XP_006714482
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LAIVAQWCE 9
          L +VA+ CE
Sbjct: 67 LVVVAEHCE 75
>NP_060498
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AIVAQW 7
          AIV+QW
Sbjct: 66 AIVSQW 71
>NP_001277482
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   IVAQW 7
           IVAQW
Sbjct: 251 IVAQW 255
>NP_001277486
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   IVAQW 7
           IVAQW
Sbjct: 251 IVAQW 255
>NP_001277558
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   IVAQW 7
           IVAQW
Sbjct: 251 IVAQW 255
>NP_057083
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   IVAQW 7
           IVAQW
Sbjct: 251 IVAQW 255
>NP_001127923
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAIVAQWCE 9
           L +VA+W E
Sbjct: 106 LKVVAEWEE 114
>NP_001127922
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAIVAQWCE 9
           L +VA+W E
Sbjct: 208 LKVVAEWEE 216
>NP_690877
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAIVAQWCE 9
           L +VA+W E
Sbjct: 208 LKVVAEWEE 216
>NP_077283
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LAIVAQW 7
           LA+V++W
Sbjct: 250 LAVVSKW 256
>XP_006726390
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 466 LAVFFLWCQ 474
>XP_006726389
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 584 LAVFFLWCQ 592
>XP_006726388
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
>XP_006726387
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
>XP_006711142
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 584 LAVFFLWCQ 592
>XP_006711141
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
>XP_006711140
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
>XP_006710131
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 466 LAVFFLWCQ 474
>XP_006710130
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 584 LAVFFLWCQ 592
>XP_006710129
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
>XP_006710128
          Length = 1497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   LAIVAQWCE 9
           LA+   WC+
Sbjct: 602 LAVFFLWCQ 610
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.133    0.525 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 589,188
Number of extensions: 539
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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