Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              20     509
NP_003897                                                              17    3301
XP_006724127                                                           17    3301
XP_005261262                                                           17    3301
XP_005261261                                                           17    3301
XP_005261263                                                           17    3301
XP_005261260                                                           17    3301
NP_777602                                                              17    4312
NP_660337                                                              17    4312
XP_006720926                                                           17    4312
XP_006720925                                                           17    4312
XP_006720924                                                           17    4312
XP_006720923                                                           17    4312
XP_005255218                                                           17    4312
XP_005255217                                                           17    4312
XP_005268862                                                           17    4312
XP_005268861                                                           17    4312
NP_001182155                                                           16    5631
NP_005928                                                              16    5631
NP_057686                                                              16    5631
NP_057419                                                              16    5631
XP_006725391                                                           16    5631
XP_006725390                                                           16    5631
XP_006725387                                                           16    5631
XP_006724999                                                           16    5631
XP_006724998                                                           16    5631
XP_005257438                                                           16    5631
XP_005257437                                                           16    5631
XP_005257436                                                           16    5631
NP_005076                                                              16    7355
NP_056039                                                              16    7355
NP_001106207                                                           16    7355
NP_001274170                                                           16    7355
NP_001012534                                                           16    7355
NP_001012532                                                           16    7355
NP_112188                                                              16    7355
XP_005256892                                                           16    7355
XP_005256891                                                           16    7355
XP_005256890                                                           16    7355
XP_005272276                                                           16    7355
XP_005272275                                                           16    7355
XP_006717355                                                           16    7355
XP_005272274                                                           16    7355
XP_005272273                                                           16    7355
XP_006713141                                                           16    7355
XP_006713140                                                           16    7355
XP_005265056                                                           16    7355
NP_060098                                                              15    9605
NP_001120680                                                           15    9605
NP_001138363                                                           15    9605
NP_057670                                                              15    9605
NP_001229808                                                           15    9605
NP_001229807                                                           15    9605
NP_001229805                                                           15    9605
NP_037460                                                              15    9605
NP_064501                                                              15    9605
NP_001121899                                                           15    9605
NP_001121900                                                           15    9605
NP_001229806                                                           15    9605
NP_001229804                                                           15    9605
NP_060725                                                              15    9605
XP_005267813                                                           15    9605
XP_005267812                                                           15    9605
XP_005267811                                                           15    9605
XP_006714306                                                           15    9605
XP_006714305                                                           15    9605
XP_005263139                                                           15    9605
NP_803875                                                              15    9605
>NP_005350
          Length = 552

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAFQPAISN 9
           LAFQP ISN
Sbjct: 308 LAFQPPISN 316
>NP_003897
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>XP_006724127
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>XP_005261262
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>XP_005261261
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>XP_005261263
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>XP_005261260
          Length = 1980

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AFQPAISN 9
           AF PA+SN
Sbjct: 221 AFTPALSN 228
>NP_777602
          Length = 694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           LAFQ  +SN
Sbjct: 293 LAFQKGVSN 301
>NP_660337
          Length = 1748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_006720926
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_006720925
          Length = 1674

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_006720924
          Length = 1679

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_006720923
          Length = 1738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_005255218
          Length = 1750

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_005255217
          Length = 1751

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           L F+PAIS
Sbjct: 182 LCFEPAIS 189
>XP_005268862
          Length = 694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           LAFQ  +SN
Sbjct: 293 LAFQKGVSN 301
>XP_005268861
          Length = 694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           LAFQ  +SN
Sbjct: 293 LAFQKGVSN 301
>NP_001182155
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FQPAIS 8
           FQPAIS
Sbjct: 278 FQPAIS 283
>NP_005928
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 342 FQPAVSS 348
>NP_057686
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AFQPAIS 8
          AFQP++S
Sbjct: 42 AFQPSVS 48
>NP_057419
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FQPAIS 8
           FQPAIS
Sbjct: 386 FQPAIS 391
>XP_006725391
          Length = 992

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 369 FQPAVSS 375
>XP_006725390
          Length = 1004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 253 FQPAVSS 259
>XP_006725387
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 369 FQPAVSS 375
>XP_006724999
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FQPAIS 8
           FQPAIS
Sbjct: 195 FQPAIS 200
>XP_006724998
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FQPAIS 8
           FQPAIS
Sbjct: 386 FQPAIS 391
>XP_005257438
          Length = 992

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 369 FQPAVSS 375
>XP_005257437
          Length = 1004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 253 FQPAVSS 259
>XP_005257436
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FQPAISN 9
           FQPA+S+
Sbjct: 369 FQPAVSS 375
>NP_005076
          Length = 2090

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1545 QPAVSN 1550
>NP_056039
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAFQPAISN 9
           ++ QPA+SN
Sbjct: 762 ISAQPALSN 770
>NP_001106207
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LAFQPAISN 9
            ++ QPA+SN
Sbjct: 1199 ISAQPALSN 1207
>NP_001274170
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LAFQPAIS 8
          ++FQPA++
Sbjct: 4  ISFQPAVA 11
>NP_001012534
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LAFQPAIS 8
          ++FQPA++
Sbjct: 4  ISFQPAVA 11
>NP_001012532
          Length = 220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LAFQPAIS 8
          ++FQPA++
Sbjct: 4  ISFQPAVA 11
>NP_112188
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LAFQPAIS 8
          ++FQPA++
Sbjct: 4  ISFQPAVA 11
>XP_005256892
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LAFQPAIS 8
          L FQPA++
Sbjct: 18 LGFQPALA 25
>XP_005256891
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LAFQPAIS 8
          L FQPA++
Sbjct: 18 LGFQPALA 25
>XP_005256890
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LAFQPAIS 8
          L FQPA++
Sbjct: 18 LGFQPALA 25
>XP_005272276
          Length = 2036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1491 QPAVSN 1496
>XP_005272275
          Length = 2083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1538 QPAVSN 1543
>XP_006717355
          Length = 2120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1575 QPAVSN 1580
>XP_005272274
          Length = 2121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1576 QPAVSN 1581
>XP_005272273
          Length = 2132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QPAISN 9
            QPA+SN
Sbjct: 1587 QPAVSN 1592
>XP_006713141
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAFQPAISN 9
           ++ QPA+SN
Sbjct: 803 ISAQPALSN 811
>XP_006713140
          Length = 1629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LAFQPAISN 9
            ++ QPA+SN
Sbjct: 1158 ISAQPALSN 1166
>XP_005265056
          Length = 1670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LAFQPAISN 9
            ++ QPA+SN
Sbjct: 1199 ISAQPALSN 1207
>NP_060098
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           L +QP +SN
Sbjct: 590 LQYQPNLSN 598
>NP_001120680
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           L +QP +SN
Sbjct: 590 LQYQPNLSN 598
>NP_001138363
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFQPAI 7
          AFQPA+
Sbjct: 65 AFQPAL 70
>NP_057670
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFQPAI 7
          AFQPA+
Sbjct: 65 AFQPAL 70
>NP_001229808
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 465 VAFQPSI 471
>NP_001229807
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 465 VAFQPSI 471
>NP_001229805
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 530 VAFQPSI 536
>NP_037460
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LAFQPA 6
           +AFQPA
Sbjct: 109 MAFQPA 114
>NP_064501
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           LAFQP+ +
Sbjct: 742 LAFQPSFT 749
>NP_001121899
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           LAFQP+ +
Sbjct: 741 LAFQPSFT 748
>NP_001121900
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LAFQPAIS 8
           LAFQP+ +
Sbjct: 732 LAFQPSFT 739
>NP_001229806
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 509 VAFQPSI 515
>NP_001229804
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 600 VAFQPSI 606
>NP_060725
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LAFQPAI 7
           +AFQP+I
Sbjct: 535 VAFQPSI 541
>XP_005267813
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFQPAI 7
          AFQPA+
Sbjct: 65 AFQPAL 70
>XP_005267812
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFQPAI 7
          AFQPA+
Sbjct: 65 AFQPAL 70
>XP_005267811
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFQPAI 7
          AFQPA+
Sbjct: 65 AFQPAL 70
>XP_006714306
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           L +QP +SN
Sbjct: 590 LQYQPNLSN 598
>XP_006714305
          Length = 1902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           L +QP +SN
Sbjct: 590 LQYQPNLSN 598
>XP_005263139
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAFQPAISN 9
           L +QP +SN
Sbjct: 590 LQYQPNLSN 598
>NP_803875
          Length = 4243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    FQPAISN 9
            F P+ISN
Sbjct: 1564 FSPSISN 1570
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.130    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 582,649
Number of extensions: 623
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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