Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
XP_005266703                                                           20     390
NP_689752                                                              17    2528
NP_001030022                                                           16    5631
NP_004760                                                              16    5631
NP_064717                                                              16    5631
NP_061873                                                              16    5631
NP_064718                                                              16    5631
NP_056169                                                              16    5631
XP_005248369                                                           16    5631
NP_001157030                                                           16    7355
NP_000939                                                              16    7355
NP_001252516                                                           16    7355
NP_689618                                                              16    7355
NP_001123910                                                           16    7355
NP_003118                                                              16    7355
NP_775960                                                              16    7355
NP_001182461                                                           16    7355
NP_001271286                                                           16    7355
NP_056382                                                              16    7355
NP_001185947                                                           16    7355
NP_001185946                                                           16    7355
NP_001273506                                                           16    7355
NP_003117                                                              16    7355
NP_060161                                                              16    7355
XP_005254549                                                           16    7355
XP_005254096                                                           16    7355
XP_005254095                                                           16    7355
XP_006718558                                                           16    7355
XP_005273953                                                           16    7355
XP_005273952                                                           16    7355
XP_005273950                                                           16    7355
XP_006717317                                                           16    7355
XP_006717316                                                           16    7355
XP_006717315                                                           16    7355
XP_006717314                                                           16    7355
XP_006717313                                                           16    7355
XP_006717312                                                           16    7355
XP_006717311                                                           16    7355
XP_006717310                                                           16    7355
XP_006717309                                                           16    7355
XP_006717308                                                           16    7355
XP_006714593                                                           16    7355
XP_005248487                                                           16    7355
NP_079440                                                              15    9605
NP_001128360                                                           15    9605
NP_001268677                                                           15    9605
NP_001129476                                                           15    9605
NP_001116203                                                           15    9605
NP_056056                                                              15    9605
NP_689854                                                              15    9605
NP_055447                                                              15    9605
NP_001269596                                                           15    9605
NP_001269595                                                           15    9605
NP_001269594                                                           15    9605
NP_001269593                                                           15    9605
NP_001269597                                                           15    9605
NP_001269592                                                           15    9605
XP_005261319                                                           15    9605
XP_006724151                                                           15    9605
XP_006724150                                                           15    9605
XP_006724149                                                           15    9605
XP_006724148                                                           15    9605
XP_006724147                                                           15    9605
XP_006724146                                                           15    9605
XP_006724145                                                           15    9605
XP_006724144                                                           15    9605
XP_006719336                                                           15    9605
XP_006719335                                                           15    9605
XP_005271541                                                           15    9605
XP_005271538                                                           15    9605
XP_006718456                                                           15    9605
XP_006718455                                                           15    9605
XP_005253308                                                           15    9605
XP_006718454                                                           15    9605
XP_005253306                                                           15    9605
NP_976249                                                              15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LADRRESHK 9
            LAD RESHK
Sbjct: 1307 LADSRESHK 1315
>XP_005266703
          Length = 1501

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LADRRESHK 9
           LAD RESHK
Sbjct: 638 LADSRESHK 646
>NP_689752
          Length = 536

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LADRRESHK 9
           LADR+ +HK
Sbjct: 349 LADRQANHK 357
>NP_001030022
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADRRESHK 9
           AD+ +SHK
Sbjct: 271 ADKEKSHK 278
>NP_004760
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D RESH+
Sbjct: 77 DERESHR 83
>NP_064717
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D RESH+
Sbjct: 77 DERESHR 83
>NP_061873
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADRRESHK 9
           AD+ +SHK
Sbjct: 130 ADKEKSHK 137
>NP_064718
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D RESH+
Sbjct: 77 DERESHR 83
>NP_056169
          Length = 1749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LADRRESHK 9
           L DRRE H+
Sbjct: 287 LDDRRELHQ 295
>XP_005248369
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADRRESHK 9
           AD+ +SHK
Sbjct: 149 ADKEKSHK 156
>NP_001157030
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           RR+SHK
Sbjct: 204 RRDSHK 209
>NP_000939
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           RR+SHK
Sbjct: 204 RRDSHK 209
>NP_001252516
          Length = 157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  DRRESH 8
          D+RESH
Sbjct: 63 DQRESH 68
>NP_689618
          Length = 988

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  DRRESHK 9
          D RE HK
Sbjct: 22 DEREKHK 28
>NP_001123910
          Length = 2477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 399 LLDRHQEHK 407
>NP_003118
          Length = 2472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 399 LLDRHQEHK 407
>NP_775960
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LADRRESH 8
           LADR E H
Sbjct: 126 LADRYECH 133
>NP_001182461
          Length = 2452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 399 LLDRHQEHK 407
>NP_001271286
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           +RESHK
Sbjct: 315 KRESHK 320
>NP_056382
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DRRESH 8
           +RRESH
Sbjct: 821 ERRESH 826
>NP_001185947
          Length = 642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           +RESHK
Sbjct: 281 KRESHK 286
>NP_001185946
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           +RESHK
Sbjct: 330 KRESHK 335
>NP_001273506
          Length = 2353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRESHK 9
            RRE+HK
Sbjct: 2237 RRENHK 2242
>NP_003117
          Length = 2419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 408 LLDRHQQHK 416
>NP_060161
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           +RESHK
Sbjct: 325 KRESHK 330
>XP_005254549
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRESHK 9
          +RESHK
Sbjct: 31 KRESHK 36
>XP_005254096
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DRRESH 8
           +RRESH
Sbjct: 821 ERRESH 826
>XP_005254095
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DRRESH 8
           +RRESH
Sbjct: 821 ERRESH 826
>XP_006718558
          Length = 1841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRESHK 9
            RRE+HK
Sbjct: 1724 RRENHK 1729
>XP_005273953
          Length = 2171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRESHK 9
            RRE+HK
Sbjct: 2054 RRENHK 2059
>XP_005273952
          Length = 2245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRESHK 9
            RRE+HK
Sbjct: 2128 RRENHK 2133
>XP_005273950
          Length = 2354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRESHK 9
            RRE+HK
Sbjct: 2237 RRENHK 2242
>XP_006717317
          Length = 2498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 399 LLDRHQEHK 407
>XP_006717316
          Length = 2464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717315
          Length = 2469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717314
          Length = 2478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 399 LLDRHQEHK 407
>XP_006717313
          Length = 2483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717312
          Length = 2484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717311
          Length = 2489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717310
          Length = 2490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717309
          Length = 2505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006717308
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 411 LLDRHQEHK 419
>XP_006714593
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  DRRESHK 9
          D RE HK
Sbjct: 22 DEREKHK 28
>XP_005248487
          Length = 947

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  DRRESHK 9
          D RE HK
Sbjct: 22 DEREKHK 28
>NP_079440
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 382 LCDRHKRHK 390
>NP_001128360
          Length = 1358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DRRESHK 9
           DRRE H+
Sbjct: 209 DRREFHE 215
>NP_001268677
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 223 LCDRHKRHK 231
>NP_001129476
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001116203
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_056056
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_689854
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LADRRESHK 9
           ++DR +SH+
Sbjct: 250 ISDRNKSHE 258
>NP_055447
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269596
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269595
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269594
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269593
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269597
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_001269592
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_005261319
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724151
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724150
          Length = 2154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724149
          Length = 2168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724148
          Length = 2176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724147
          Length = 2187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724146
          Length = 2193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724145
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006724144
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006719336
          Length = 1779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LADRRESHK 9
           ++DR +SH+
Sbjct: 250 ISDRNKSHE 258
>XP_006719335
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LADRRESHK 9
           ++DR +SH+
Sbjct: 250 ISDRNKSHE 258
>XP_005271541
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 324 LCDRHKRHK 332
>XP_005271538
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LADRRESHK 9
           L DR + HK
Sbjct: 382 LCDRHKRHK 390
>XP_006718456
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006718455
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_005253308
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_006718454
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>XP_005253306
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRRESHK 9
          D+R SHK
Sbjct: 70 DKRGSHK 76
>NP_976249
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRESHK 9
           RRESH+
Sbjct: 120 RRESHQ 125
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.125    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 635,473
Number of extensions: 1268
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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