Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     869
NP_055573                                                              17    4312
XP_005271606                                                           17    4312
XP_005271605                                                           17    4312
XP_005271603                                                           17    4312
XP_005271602                                                           17    4312
XP_005245660                                                           17    4312
NP_001073895                                                           17    4312
NP_004706                                                              16    5631
NP_001189433                                                           16    5631
NP_430255                                                              16    5631
XP_006722637                                                           16    5631
XP_005266839                                                           16    5631
NP_659434                                                              15    9605
NP_056142                                                              15    9605
NP_001027467                                                           15    9605
NP_001273578                                                           15    9605
NP_003567                                                              15    9605
NP_001017979                                                           15    9605
NP_001153244                                                           15    9605
NP_001271236                                                           15    9605
NP_001271235                                                           15    9605
NP_071918                                                              15    9605
NP_001159580                                                           15    9605
NP_057165                                                              15    9605
NP_004618                                                              15    9605
NP_001139690                                                           15    9605
NP_001153073                                                           15    9605
NP_004240                                                              15    9605
XP_005261118                                                           15    9605
XP_005261117                                                           15    9605
XP_005261116                                                           15    9605
XP_005257079                                                           15    9605
XP_006721746                                                           15    9605
XP_006721745                                                           15    9605
XP_005257078                                                           15    9605
XP_005257077                                                           15    9605
XP_005256572                                                           15    9605
XP_005254649                                                           15    9605
XP_005254648                                                           15    9605
XP_005254135                                                           15    9605
XP_005254136                                                           15    9605
XP_005262922                                                           15    9605
XP_005262921                                                           15    9605
XP_005262920                                                           15    9605
XP_005262919                                                           15    9605
XP_005262918                                                           15    9605
XP_005248275                                                           15    9605
XP_006714050                                                           15    9605
XP_005248274                                                           15    9605
XP_005248272                                                           15    9605
XP_006711311                                                           15    9605
XP_005245106                                                           15    9605
NP_620148                                                              15    9605
NP_001153245                                                           15    9605
>NP_064450
          Length = 1722

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           L DAETESQ
Sbjct: 638 LEDAETESQ 646
>NP_055573
          Length = 992

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LADAETESQ 9
           L++AETES+
Sbjct: 704 LSEAETESK 712
>XP_005271606
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LADAETESQ 9
          L++AETES+
Sbjct: 84 LSEAETESK 92
>XP_005271605
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LADAETESQ 9
           L++AETES+
Sbjct: 129 LSEAETESK 137
>XP_005271603
          Length = 907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LADAETESQ 9
           L++AETES+
Sbjct: 704 LSEAETESK 712
>XP_005271602
          Length = 915

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LADAETESQ 9
           L++AETES+
Sbjct: 704 LSEAETESK 712
>XP_005245660
          Length = 1158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LADAETES 8
          ++DAETES
Sbjct: 41 VSDAETES 48
>NP_001073895
          Length = 1158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LADAETES 8
          ++DAETES
Sbjct: 41 VSDAETES 48
>NP_004706
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           +AETESQ
Sbjct: 553 EAETESQ 559
>NP_001189433
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           +AETESQ
Sbjct: 434 EAETESQ 440
>NP_430255
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           +AETESQ
Sbjct: 553 EAETESQ 559
>XP_006722637
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           +AETESQ
Sbjct: 452 EAETESQ 458
>XP_005266839
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           +AETESQ
Sbjct: 553 EAETESQ 559
>NP_659434
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LADAETESQ 9
           LAD E ES+
Sbjct: 289 LADLEEESE 297
>NP_056142
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           DAET+S+
Sbjct: 509 DAETDSE 515
>NP_001027467
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADAETESQ 9
           +DAET+ Q
Sbjct: 308 SDAETDGQ 315
>NP_001273578
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADAETESQ 9
           +DAET+ Q
Sbjct: 289 SDAETDGQ 296
>NP_003567
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADAETESQ 9
           +DAET+ Q
Sbjct: 320 SDAETDGQ 327
>NP_001017979
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>NP_001153244
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>NP_001271236
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LADAETES 8
           LADA T+S
Sbjct: 221 LADAATDS 228
>NP_001271235
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LADAETES 8
           LADA T+S
Sbjct: 178 LADAATDS 185
>NP_071918
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LADAETES 8
            LADA T+S
Sbjct: 993  LADAATDS 1000
>NP_001159580
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>NP_057165
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>NP_004618
          Length = 174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DAETESQ 9
          DAE ESQ
Sbjct: 42 DAEQESQ 48
>NP_001139690
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DAETESQ 9
          DAE ESQ
Sbjct: 8  DAEQESQ 14
>NP_001153073
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>NP_004240
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>XP_005261118
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DAETESQ 9
          DAE ESQ
Sbjct: 8  DAEQESQ 14
>XP_005261117
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DAETESQ 9
          DAE ESQ
Sbjct: 8  DAEQESQ 14
>XP_005261116
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DAETESQ 9
          DAE ESQ
Sbjct: 8  DAEQESQ 14
>XP_005257079
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>XP_006721746
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>XP_006721745
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>XP_005257078
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>XP_005257077
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>XP_005256572
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LADAETESQ 9
           LAD E ES+
Sbjct: 289 LADLEEESE 297
>XP_005254649
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LADAETES 8
            LADA T+S
Sbjct: 1016 LADAATDS 1023
>XP_005254648
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LADAETES 8
            LADA T+S
Sbjct: 1016 LADAATDS 1023
>XP_005254135
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADAETESQ 9
           +DAET+ Q
Sbjct: 210 SDAETDGQ 217
>XP_005254136
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADAETESQ 9
           +DAET+ Q
Sbjct: 210 SDAETDGQ 217
>XP_005262922
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>XP_005262921
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>XP_005262920
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>XP_005262919
          Length = 1383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>XP_005262918
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LADAETE 7
          +AD+ETE
Sbjct: 50 IADSETE 56
>XP_005248275
          Length = 136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>XP_006714050
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>XP_005248274
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>XP_005248272
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LADAETESQ 9
         ++D+E ESQ
Sbjct: 1 MSDSEEESQ 9
>XP_006711311
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           DAET+S+
Sbjct: 443 DAETDSE 449
>XP_005245106
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DAETESQ 9
           DAET+S+
Sbjct: 463 DAETDSE 469
>NP_620148
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
>NP_001153245
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LADAETESQ 9
           +AD +TES+
Sbjct: 110 IADLDTESR 118
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283    0.101    0.224 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,229
Number of extensions: 774
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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