Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     299
NP_001087241                                                           20     299
XP_005265799                                                           20     299
XP_005265798                                                           20     299
XP_005265797                                                           20     299
NP_005202                                                              20     390
NP_001275634                                                           20     390
NP_004110                                                              19     665
NP_543149                                                              17    3301
NP_001188512                                                           17    3301
NP_543150                                                              17    3301
NP_003238                                                              17    3301
NP_001124194                                                           17    3301
XP_006724526                                                           17    3301
XP_005274501                                                           17    3301
XP_005262816                                                           17    3301
NP_057383                                                              17    4312
NP_660335                                                              16    5631
NP_005048                                                              16    5631
NP_001180201                                                           16    5631
NP_001180202                                                           16    5631
XP_006715926                                                           16    5631
XP_006715925                                                           16    5631
XP_006711540                                                           16    5631
XP_006711539                                                           16    5631
XP_005245458                                                           16    5631
XP_005245457                                                           16    5631
XP_005245456                                                           16    5631
XP_005245455                                                           16    5631
NP_060264                                                              16    7355
NP_079160                                                              16    7355
NP_001269779                                                           16    7355
NP_065196                                                              16    7355
NP_001116436                                                           16    7355
NP_071898                                                              16    7355
NP_872432                                                              16    7355
NP_115682                                                              16    7355
XP_005259715                                                           16    7355
XP_005268134                                                           16    7355
XP_005268132                                                           16    7355
XP_005251551                                                           16    7355
XP_006716857                                                           16    7355
XP_005264505                                                           16    7355
XP_005264504                                                           16    7355
XP_005264503                                                           16    7355
XP_005264502                                                           16    7355
XP_005264501                                                           16    7355
XP_005264499                                                           16    7355
NP_004813                                                              15    9605
NP_003464                                                              15    9605
NP_004531                                                              15    9605
NP_055104                                                              15    9605
NP_208384                                                              15    9605
NP_001032412                                                           15    9605
NP_001020368                                                           15    9605
XP_006724072                                                           15    9605
XP_005261045                                                           15    9605
XP_006724071                                                           15    9605
XP_006724070                                                           15    9605
XP_006721658                                                           15    9605
XP_005252660                                                           15    9605
NP_003991                                                              15    9605
NP_001020370                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVVKGNAR
Sbjct: 823 YVVKGNAR 830
>NP_001087241
          Length = 972

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVVKGNAR
Sbjct: 819 YVVKGNAR 826
>XP_005265799
          Length = 973

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVVKGNAR
Sbjct: 820 YVVKGNAR 827
>XP_005265798
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVVKGNAR
Sbjct: 823 YVVKGNAR 830
>XP_005265797
          Length = 977

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVVKGNAR
Sbjct: 824 YVVKGNAR 831
>NP_005202
          Length = 972

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           Y+VKGNAR
Sbjct: 809 YIVKGNAR 816
>NP_001275634
          Length = 972

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           Y+VKGNAR
Sbjct: 809 YIVKGNAR 816
>NP_004110
          Length = 993

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           YVV+GNAR
Sbjct: 842 YVVRGNAR 849
>NP_543149
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 39 YIVKGNRK 46
>NP_001188512
          Length = 306

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 39 YIVKGNRK 46
>NP_543150
          Length = 329

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 42 YIVKGNRK 49
>NP_003238
          Length = 1172

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YVVKGNAR 9
           YV KG+AR
Sbjct: 191 YVAKGSAR 198
>NP_001124194
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KYVVKGNA 8
          KY+V GN+
Sbjct: 7  KYIVNGNS 14
>XP_006724526
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 39 YIVKGNRK 46
>XP_005274501
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 39 YIVKGNRK 46
>XP_005262816
          Length = 329

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YVVKGNAR 9
          Y+VKGN +
Sbjct: 42 YIVKGNRK 49
>NP_057383
          Length = 509

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           K+ V+GNAR
Sbjct: 248 KHDVRGNAR 256
>NP_660335
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYVVKGNAR 9
           KYV  GN R
Sbjct: 403 KYVTYGNIR 411
>NP_005048
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 264 EYIVAGSAR 272
>NP_001180201
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 264 EYIVAGSAR 272
>NP_001180202
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 137 EYIVAGSAR 145
>XP_006715926
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYVVKGNAR 9
           KYV  GN R
Sbjct: 403 KYVTYGNIR 411
>XP_006715925
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYVVKGNAR 9
           KYV  GN R
Sbjct: 403 KYVTYGNIR 411
>XP_006711540
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KYVVKGNAR 9
          +Y+V G+AR
Sbjct: 23 EYIVAGSAR 31
>XP_006711539
          Length = 444

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 299 EYIVAGSAR 307
>XP_005245458
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 264 EYIVAGSAR 272
>XP_005245457
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 299 EYIVAGSAR 307
>XP_005245456
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 299 EYIVAGSAR 307
>XP_005245455
          Length = 573

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYVVKGNAR 9
           +Y+V G+AR
Sbjct: 299 EYIVAGSAR 307
>NP_060264
          Length = 1801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VVKGNA 8
           VVKGNA
Sbjct: 955 VVKGNA 960
>NP_079160
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YVVKGN 7
           Y+VKGN
Sbjct: 294 YLVKGN 299
>NP_001269779
          Length = 817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 575 RYITKGN 581
>NP_065196
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 522 RYITKGN 528
>NP_001116436
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 607 RYITKGN 613
>NP_071898
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VVKGNAR 9
          V+KGN R
Sbjct: 33 VIKGNGR 39
>NP_872432
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YVVKGN 7
          YV+KGN
Sbjct: 36 YVLKGN 41
>NP_115682
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           Y+++G+AR
Sbjct: 165 YILRGSAR 172
>XP_005259715
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YVVKGNAR 9
           Y+++G+AR
Sbjct: 139 YILRGSAR 146
>XP_005268134
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YVVKGN 7
           Y+VKGN
Sbjct: 112 YLVKGN 117
>XP_005268132
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YVVKGN 7
           Y+VKGN
Sbjct: 294 YLVKGN 299
>XP_005251551
          Length = 1801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VVKGNA 8
           VVKGNA
Sbjct: 955 VVKGNA 960
>XP_006716857
          Length = 1834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VVKGNA 8
           VVKGNA
Sbjct: 988 VVKGNA 993
>XP_005264505
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 302 RYITKGN 308
>XP_005264504
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 399 RYITKGN 405
>XP_005264503
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 522 RYITKGN 528
>XP_005264502
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 554 RYITKGN 560
>XP_005264501
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 554 RYITKGN 560
>XP_005264499
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           +Y+ KGN
Sbjct: 607 RYITKGN 613
>NP_004813
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KYVVKGNA 8
           KY++ GNA
Sbjct: 554 KYLLLGNA 561
>NP_003464
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YVVKGNAR 9
           Y+V GNA+
Sbjct: 414 YLVAGNAQ 421
>NP_004531
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KYVVKGN 7
           KY++KG+
Sbjct: 256 KYILKGS 262
>NP_055104
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYVVKGN 7
           KY+ KGN
Sbjct: 460 KYLKKGN 466
>NP_208384
          Length = 2080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YVVKGN 7
           YV KGN
Sbjct: 189 YVAKGN 194
>NP_001032412
          Length = 2649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YVVKGN 7
           YV KGN
Sbjct: 758 YVAKGN 763
>NP_001020368
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YVVKGN 7
           Y VKGN
Sbjct: 316 YAVKGN 321
>XP_006724072
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  KYVVKGN 7
          KY++KG+
Sbjct: 92 KYILKGS 98
>XP_005261045
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  KYVVKGN 7
          KY++KG+
Sbjct: 92 KYILKGS 98
>XP_006724071
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KYVVKGN 7
           KY++KG+
Sbjct: 256 KYILKGS 262
>XP_006724070
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KYVVKGN 7
           KY++KG+
Sbjct: 256 KYILKGS 262
>XP_006721658
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KYVVKGNA 8
           KY++ GNA
Sbjct: 554 KYLLLGNA 561
>XP_005252660
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YVVKGNAR 9
           Y+V GNA+
Sbjct: 364 YLVAGNAQ 371
>NP_003991
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YVVKGN 7
           Y VKGN
Sbjct: 326 YAVKGN 331
>NP_001020370
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   YVVKGN 7
           Y VKGN
Sbjct: 247 YAVKGN 252
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.133    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 562,957
Number of extensions: 1018
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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