Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              21     175
NP_001263689                                                           21     175
NP_001119584                                                           21     175
NP_001119590                                                           21     175
NP_001263690                                                           21     175
NP_001119587                                                           21     175
NP_001263626                                                           21     175
NP_114480                                                              18    1135
NP_114481                                                              18    1135
NP_061737                                                              18    1135
NP_689957                                                              18    1482
NP_620177                                                              16    5631
NP_000910                                                              16    5631
NP_620121                                                              16    5631
NP_620176                                                              16    5631
NP_001170777                                                           16    5631
XP_006725534                                                           16    5631
XP_006714703                                                           16    5631
XP_006714702                                                           16    5631
XP_006714701                                                           16    5631
XP_006714700                                                           16    5631
XP_006714699                                                           16    5631
XP_006714698                                                           16    5631
XP_006714697                                                           16    5631
XP_006714696                                                           16    5631
XP_006714695                                                           16    5631
NP_443155                                                              16    5631
NP_001119585                                                           16    7355
NP_001263624                                                           16    7355
NP_001119589                                                           16    7355
NP_694972                                                              16    7355
NP_001263628                                                           16    7355
NP_001438                                                              16    7355
XP_006714824                                                           16    7355
NP_001119586                                                           15    9605
NP_001263625                                                           15    9605
NP_001119588                                                           15    9605
NP_001136272                                                           15    9605
NP_899645                                                              15    9605
NP_899647                                                              15    9605
NP_899648                                                              15    9605
NP_004281                                                              15    9605
NP_001188294                                                           15    9605
NP_001269649                                                           15    9605
NP_001269650                                                           15    9605
NP_001269648                                                           15    9605
NP_899646                                                              15    9605
NP_068744                                                              15    9605
NP_001269651                                                           15    9605
NP_001269652                                                           15    9605
NP_001269653                                                           15    9605
NP_001263627                                                           15    9605
NP_003150                                                              15    9605
NP_001032420                                                           15    9605
NP_079357                                                              15    9605
XP_006724574                                                           15    9605
XP_005268598                                                           15    9605
XP_005268597                                                           15    9605
XP_005268596                                                           15    9605
XP_005268595                                                           15    9605
XP_005268594                                                           15    9605
XP_005268593                                                           15    9605
XP_006714302                                                           15    9605
XP_005263127                                                           15    9605
NP_001138424                                                           15    9605
NP_061908                                                              15    9605
>NP_000537
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 326 EYFTLQIRG 334
>NP_001263689
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 287 EYFTLQIRG 295
>NP_001119584
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 326 EYFTLQIRG 334
>NP_001119590
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 287 EYFTLQIRG 295
>NP_001263690
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 287 EYFTLQIRG 295
>NP_001119587
          Length = 261

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 194 EYFTLQIRG 202
>NP_001263626
          Length = 234

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KYFTLQIRG 9
           +YFTLQIRG
Sbjct: 167 EYFTLQIRG 175
>NP_114480
          Length = 837

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   YFTLQIRG 9
           YF+LQ+RG
Sbjct: 178 YFSLQLRG 185
>NP_114481
          Length = 750

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   YFTLQIRG 9
           YF+LQ+RG
Sbjct: 178 YFSLQLRG 185
>NP_061737
          Length = 935

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   YFTLQIRG 9
           YF+LQ+RG
Sbjct: 178 YFSLQLRG 185
>NP_689957
          Length = 2213

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    KYFTLQIR 8
            +YFT+Q+R
Sbjct: 1510 RYFTMQVR 1517
>NP_620177
          Length = 887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>NP_000910
          Length = 974

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>NP_620121
          Length = 905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>NP_620176
          Length = 866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>NP_001170777
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006725534
          Length = 1174

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           KYF+LQ+
Sbjct: 746 KYFSLQL 752
>XP_006714703
          Length = 866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714702
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714701
          Length = 905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714700
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714699
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714698
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714697
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714696
          Length = 974

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>XP_006714695
          Length = 974

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KYFTLQI 7
           KYF LQ+
Sbjct: 160 KYFVLQV 166
>NP_443155
          Length = 1325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           KYF+LQ+
Sbjct: 897 KYFSLQL 903
>NP_001119585
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           +YFTLQ+
Sbjct: 326 EYFTLQM 332
>NP_001263624
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           +YFTLQ+
Sbjct: 287 EYFTLQM 293
>NP_001119589
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           +YFTLQ+
Sbjct: 194 EYFTLQM 200
>NP_694972
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 851 YFTLQL 856
>NP_001263628
          Length = 187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           +YFTLQ+
Sbjct: 167 EYFTLQM 173
>NP_001438
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YFTLQIRG 9
           YF  QIRG
Sbjct: 342 YFYSQIRG 349
>XP_006714824
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YFTLQIRG 9
           YF  QIRG
Sbjct: 342 YFYSQIRG 349
>NP_001119586
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYFTLQ 6
           +YFTLQ
Sbjct: 326 EYFTLQ 331
>NP_001263625
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYFTLQ 6
           +YFTLQ
Sbjct: 287 EYFTLQ 292
>NP_001119588
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYFTLQ 6
           +YFTLQ
Sbjct: 194 EYFTLQ 199
>NP_001136272
          Length = 3144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FTLQIR 8
            FTLQ+R
Sbjct: 2578 FTLQVR 2583
>NP_899645
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 124 YFEIQIR 130
>NP_899647
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>NP_899648
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>NP_004281
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>NP_001188294
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>NP_001269649
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 95  YFTLQM 100
>NP_001269650
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YFTLQI 7
          YFTLQ+
Sbjct: 13 YFTLQM 18
>NP_001269648
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 101 YFTLQM 106
>NP_899646
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>NP_068744
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 143 YFTLQM 148
>NP_001269651
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YFTLQI 7
          YFTLQ+
Sbjct: 13 YFTLQM 18
>NP_001269652
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 143 YFTLQM 148
>NP_001269653
          Length = 124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YFTLQI 7
           YFTLQ+
Sbjct: 101 YFTLQM 106
>NP_001263627
          Length = 182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYFTLQ 6
           +YFTLQ
Sbjct: 167 EYFTLQ 172
>NP_003150
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TLQIRG 9
           TLQ+RG
Sbjct: 977 TLQVRG 982
>NP_001032420
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TLQIRG 9
           TLQ+RG
Sbjct: 977 TLQVRG 982
>NP_079357
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YFTLQIRG 9
          YF LQ+ G
Sbjct: 50 YFWLQLEG 57
>XP_006724574
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TLQIRG 9
           TLQ+RG
Sbjct: 977 TLQVRG 982
>XP_005268598
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 124 YFEIQIR 130
>XP_005268597
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 124 YFEIQIR 130
>XP_005268596
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 124 YFEIQIR 130
>XP_005268595
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>XP_005268594
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>XP_005268593
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YFTLQIR 8
           YF +QIR
Sbjct: 250 YFEIQIR 256
>XP_006714302
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           K+FT+QI
Sbjct: 449 KHFTVQI 455
>XP_005263127
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           K+FT+QI
Sbjct: 449 KHFTVQI 455
>NP_001138424
          Length = 2172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    KYFTLQIR 8
            +Y+T+Q R
Sbjct: 1433 RYYTIQTR 1440
>NP_061908
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KYFTLQI 7
           K+FT+QI
Sbjct: 449 KHFTVQI 455
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.153    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 412,024
Number of extensions: 446
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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