Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
XP_005270499                                                           17    4312
XP_005262370                                                           16    5631
XP_005262369                                                           16    5631
XP_006724779                                                           16    5631
XP_006722254                                                           16    5631
XP_006712467                                                           16    5631
XP_005263970                                                           16    5631
XP_006712466                                                           16    5631
NP_443189                                                              16    5631
NP_054763                                                              16    5631
NP_852091                                                              16    7355
NP_997716                                                              16    7355
NP_001130015                                                           16    7355
NP_001130010                                                           16    7355
NP_055646                                                              16    7355
XP_006713495                                                           16    7355
NP_079523                                                              16    7355
NP_001107578                                                           15    9605
NP_001245271                                                           15    9605
NP_001245269                                                           15    9605
NP_689582                                                              15    9605
NP_001245270                                                           15    9605
NP_001245272                                                           15    9605
NP_722519                                                              15    9605
NP_001077362                                                           15    9605
XP_005270500                                                           15    9605
XP_005270498                                                           15    9605
XP_005270497                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KYFIK ANR
Sbjct: 102 KYFIKCANR 110
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KYFIK ANR
Sbjct: 102 KYFIKCANR 110
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KYFIK ANR
Sbjct: 102 KYFIKCANR 110
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KYFIK ANR
Sbjct: 102 KYFIKCANR 110
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KYFIK ANR
Sbjct: 102 KYFIKCANR 110
>XP_005270499
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           K F+KR+N+
Sbjct: 540 KSFVKRSNK 548
>XP_005262370
          Length = 664

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KY+ +++NR
Sbjct: 587 KYYARKSNR 595
>XP_005262369
          Length = 664

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KY+ +++NR
Sbjct: 587 KYYARKSNR 595
>XP_006724779
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KY+ +++NR
Sbjct: 614 KYYARKSNR 622
>XP_006722254
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KYFIKRANR 9
           KYF+  ANR
Sbjct: 190 KYFMIAANR 198
>XP_006712467
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYFIKRANR 9
           KY +KR +R
Sbjct: 139 KYLVKRQSR 147
>XP_005263970
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYFIKRANR 9
           KY +KR +R
Sbjct: 156 KYLVKRQSR 164
>XP_006712466
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYFIKRANR 9
           KY +KR +R
Sbjct: 156 KYLVKRQSR 164
>NP_443189
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           KY+ +++NR
Sbjct: 614 KYYARKSNR 622
>NP_054763
          Length = 259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYFIKRANR 9
           KY +KR +R
Sbjct: 139 KYLVKRQSR 147
>NP_852091
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YFIKRAN 8
           YFIK+A+
Sbjct: 513 YFIKKAH 519
>NP_997716
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  IKRANR 9
          IKRANR
Sbjct: 64 IKRANR 69
>NP_001130015
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  IKRANR 9
          IKRANR
Sbjct: 16 IKRANR 21
>NP_001130010
          Length = 1090

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFIKRANR 9
           Y+I+ ANR
Sbjct: 331 YYIRLANR 338
>NP_055646
          Length = 2925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    KYFIKR 6
            KYFI+R
Sbjct: 1669 KYFIRR 1674
>XP_006713495
          Length = 2969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    KYFIKR 6
            KYFI+R
Sbjct: 1713 KYFIRR 1718
>NP_079523
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFIKRANR 9
           Y+I+ ANR
Sbjct: 300 YYIRLANR 307
>NP_001107578
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 621 FVKRSNK 627
>NP_001245271
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 585 FVKRSNK 591
>NP_001245269
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 620 FVKRSNK 626
>NP_689582
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 573 FVKRSNK 579
>NP_001245270
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 588 FVKRSNK 594
>NP_001245272
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 553 FVKRSNK 559
>NP_722519
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYFIKRANR 9
           K+ I+R+NR
Sbjct: 281 KFDIRRSNR 289
>NP_001077362
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IKRANR 9
           +KRANR
Sbjct: 365 VKRANR 370
>XP_005270500
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 541 FVKRSNK 547
>XP_005270498
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 573 FVKRSNK 579
>XP_005270497
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FIKRANR 9
           F+KR+N+
Sbjct: 589 FVKRSNK 595
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.144    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,359
Number of extensions: 381
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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