Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1135
XP_005266703                                                           18    1135
NP_003625                                                              17    3301
NP_001189431                                                           17    3301
NP_001074008                                                           17    3301
XP_005261846                                                           17    3301
NP_001243506                                                           16    5631
NP_006004                                                              16    5631
NP_004035                                                              16    5631
NP_940862                                                              16    5631
XP_006726617                                                           16    5631
XP_006720409                                                           16    5631
XP_005250198                                                           16    5631
XP_006712608                                                           16    5631
XP_005270606                                                           16    5631
XP_006710456                                                           16    5631
XP_006710039                                                           16    5631
NP_660311                                                              16    5631
NP_542784                                                              16    5631
NP_060783                                                              16    7355
NP_005602                                                              16    7355
NP_001139281                                                           16    7355
NP_115609                                                              16    7355
NP_001070654                                                           16    7355
NP_079005                                                              16    7355
XP_006723449                                                           16    7355
XP_005256140                                                           16    7355
XP_005268184                                                           16    7355
XP_005268183                                                           16    7355
XP_006713297                                                           16    7355
XP_006713296                                                           16    7355
XP_006713295                                                           16    7355
XP_005265345                                                           16    7355
XP_006713294                                                           16    7355
XP_006713293                                                           16    7355
XP_006713292                                                           16    7355
XP_006713291                                                           16    7355
XP_006713290                                                           16    7355
XP_006713289                                                           16    7355
XP_005265340                                                           16    7355
XP_005265339                                                           16    7355
XP_006713288                                                           16    7355
XP_005265337                                                           16    7355
XP_005265336                                                           16    7355
XP_006713287                                                           16    7355
XP_006713286                                                           16    7355
XP_005265332                                                           16    7355
XP_006713285                                                           16    7355
XP_006713284                                                           16    7355
XP_006713283                                                           16    7355
NP_689681                                                              15    9605
NP_877398                                                              15    9605
NP_056007                                                              15    9605
NP_076919                                                              15    9605
XP_005260738                                                           15    9605
XP_006723618                                                           15    9605
XP_006721789                                                           15    9605
XP_006721788                                                           15    9605
>NP_443179
          Length = 2170

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KYEQSNSEA 9
           KYEQS SEA
Sbjct: 738 KYEQSISEA 746
>XP_005266703
          Length = 1501

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KYEQSNSEA 9
          KYEQS SEA
Sbjct: 69 KYEQSISEA 77
>NP_003625
          Length = 284

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYEQSNSEA 9
           KY Q N EA
Sbjct: 209 KYRQENQEA 217
>NP_001189431
          Length = 264

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYEQSNSEA 9
           KY Q N EA
Sbjct: 189 KYRQENQEA 197
>NP_001074008
          Length = 1101

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KYEQSNSE 8
           KY Q+NSE
Sbjct: 598 KYAQANSE 605
>XP_005261846
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KYEQSNSEA 9
           KY Q N EA
Sbjct: 185 KYRQENQEA 193
>NP_001243506
          Length = 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KYEQSNSEA 9
          +YEQ +SEA
Sbjct: 56 EYEQLSSEA 64
>NP_006004
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KYEQSNSEA 9
          +YEQ +SEA
Sbjct: 56 EYEQLSSEA 64
>NP_004035
          Length = 592

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KYEQSNS 7
           KY QSNS
Sbjct: 426 KYTQSNS 432
>NP_940862
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KYEQSNSE 8
           KYE+ N+E
Sbjct: 567 KYEEMNAE 574
>XP_006726617
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYEQSNSEA 9
           KY ++N+EA
Sbjct: 781 KYNKNNTEA 789
>XP_006720409
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYEQSNSEA 9
           KY ++N+EA
Sbjct: 781 KYNKNNTEA 789
>XP_005250198
          Length = 183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EQSNSEA 9
          E+SNSEA
Sbjct: 92 EESNSEA 98
>XP_006712608
          Length = 533

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KYEQSNS 7
           KY QSNS
Sbjct: 367 KYTQSNS 373
>XP_005270606
          Length = 503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KYEQSNSE 8
           KYE+ N+E
Sbjct: 437 KYEEMNAE 444
>XP_006710456
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KYEQSNSE 8
           KYE+ N+E
Sbjct: 567 KYEEMNAE 574
>XP_006710039
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KYEQSNSEA 9
           KY ++N+EA
Sbjct: 677 KYNKNNTEA 685
>NP_660311
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EQSNSEA 9
           E+SNSEA
Sbjct: 153 EESNSEA 159
>NP_542784
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KYEQSNSEA 9
          +YEQ +SEA
Sbjct: 56 EYEQLSSEA 64
>NP_060783
          Length = 1582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>NP_005602
          Length = 1139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KYEQSNSEA 9
            KY Q+N +A
Sbjct: 1023 KYSQANMDA 1031
>NP_001139281
          Length = 2036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EQSNSE 8
            EQSNSE
Sbjct: 1806 EQSNSE 1811
>NP_115609
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYEQSN 6
           KYE+SN
Sbjct: 501 KYEESN 506
>NP_001070654
          Length = 2003

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EQSNSE 8
            EQSNSE
Sbjct: 1773 EQSNSE 1778
>NP_079005
          Length = 1995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EQSNSE 8
            EQSNSE
Sbjct: 1765 EQSNSE 1770
>XP_006723449
          Length = 2003

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EQSNSE 8
            EQSNSE
Sbjct: 1773 EQSNSE 1778
>XP_005256140
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           KY Q+N +A
Sbjct: 949 KYSQANMDA 957
>XP_005268184
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYEQSN 6
           KYE+SN
Sbjct: 402 KYEESN 407
>XP_005268183
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KYEQSN 6
           KYE+SN
Sbjct: 443 KYEESN 448
>XP_006713297
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713296
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713295
          Length = 1620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 351 RYEEGESEA 359
>XP_005265345
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713294
          Length = 1652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713293
          Length = 1667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713292
          Length = 1670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713291
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713290
          Length = 1690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 351 RYEEGESEA 359
>XP_006713289
          Length = 1697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_005265340
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_005265339
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_006713288
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_005265337
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_005265336
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_006713287
          Length = 1704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 365 RYEEGESEA 373
>XP_006713286
          Length = 1707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_005265332
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713285
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713284
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>XP_006713283
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           +YE+  SEA
Sbjct: 383 RYEEGESEA 391
>NP_689681
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   KYEQSNSE 8
           KY Q N E
Sbjct: 322 KYSQDNKE 329
>NP_877398
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           KYE +NS A
Sbjct: 277 KYEPNNSLA 285
>NP_056007
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           KYE +NS A
Sbjct: 277 KYEPNNSLA 285
>NP_076919
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YEQSNS 7
          Y+QSNS
Sbjct: 58 YQQSNS 63
>XP_005260738
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           KYE +NS A
Sbjct: 277 KYEPNNSLA 285
>XP_006723618
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KYEQSNSEA 9
           KYE +NS A
Sbjct: 277 KYEPNNSLA 285
>XP_006721789
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   KYEQSNSE 8
           KY Q N E
Sbjct: 322 KYSQDNKE 329
>XP_006721788
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   KYEQSNSE 8
           KY Q N E
Sbjct: 99  KYSQDNKE 106
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.275   0.0949    0.216 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 476,477
Number of extensions: 876
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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