Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_005237                                                              16    5631
XP_005271980                                                           16    5631
XP_006714636                                                           16    5631
XP_006714635                                                           16    5631
NP_001136245                                                           16    7355
NP_001136239                                                           16    7355
NP_001136236                                                           16    7355
NP_001136244                                                           16    7355
NP_001136238                                                           16    7355
NP_001136240                                                           16    7355
NP_001136243                                                           16    7355
NP_001136242                                                           16    7355
NP_001136235                                                           16    7355
NP_001136237                                                           16    7355
NP_001136241                                                           16    7355
NP_149045                                                              16    7355
NP_001138775                                                           16    7355
NP_653287                                                              16    7355
NP_003990                                                              16    7355
NP_848639                                                              16    7355
XP_005258911                                                           16    7355
XP_005258910                                                           16    7355
XP_006718013                                                           16    7355
XP_006714572                                                           16    7355
XP_005248442                                                           16    7355
XP_005248441                                                           16    7355
NP_001001924                                                           15    9605
NP_001001925                                                           15    9605
NP_722581                                                              15    9605
NP_065928                                                              15    9605
NP_001239542                                                           15    9605
NP_001239541                                                           15    9605
NP_001014972                                                           15    9605
NP_055312                                                              15    9605
XP_005256527                                                           15    9605
XP_005273640                                                           15    9605
XP_005273639                                                           15    9605
XP_005273638                                                           15    9605
XP_005273637                                                           15    9605
XP_005273636                                                           15    9605
XP_005273635                                                           15    9605
XP_005273634                                                           15    9605
XP_006712053                                                           15    9605
XP_005264320                                                           15    9605
XP_006712052                                                           15    9605
XP_005264319                                                           15    9605
XP_005264318                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KVTQTELTR 9
            KVTQTEL R
Sbjct: 1872 KVTQTELMR 1880
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KVTQTELTR 9
            KVTQTEL R
Sbjct: 1872 KVTQTELMR 1880
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KVTQTELTR 9
            KVTQTEL R
Sbjct: 1825 KVTQTELMR 1833
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KVTQTELTR 9
            KVTQTEL R
Sbjct: 1904 KVTQTELMR 1912
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KVTQTELTR 9
            KVTQTEL R
Sbjct: 1904 KVTQTELMR 1912
>NP_005237
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TEL +
Sbjct: 127 KVTKTELEK 135
>XP_005271980
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KVTQTELTR 9
          KVT+TEL +
Sbjct: 54 KVTKTELEK 62
>XP_006714636
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TEL +
Sbjct: 127 KVTKTELEK 135
>XP_006714635
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TEL +
Sbjct: 127 KVTKTELEK 135
>NP_001136245
          Length = 1932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 432 VTQTGITR 439
>NP_001136239
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 417 VTQTGITR 424
>NP_001136236
          Length = 1957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001136244
          Length = 1677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001136238
          Length = 1952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001136240
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 432 VTQTGITR 439
>NP_001136243
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 459 VTQTGITR 466
>NP_001136242
          Length = 1539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001136235
          Length = 1962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 459 VTQTGITR 466
>NP_001136237
          Length = 1886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001136241
          Length = 1790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 466 VTQTGITR 473
>NP_149045
          Length = 1955

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>NP_001138775
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KVTQTEL 7
          +VTQTEL
Sbjct: 78 EVTQTEL 84
>NP_653287
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KVTQTEL 7
          +VTQTEL
Sbjct: 72 EVTQTEL 78
>NP_003990
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VTQTELTR 9
           +T+TELT+
Sbjct: 827 LTETELTK 834
>NP_848639
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QTELTR 9
           QTELTR
Sbjct: 453 QTELTR 458
>XP_005258911
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QTELTR 9
           QTELTR
Sbjct: 415 QTELTR 420
>XP_005258910
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QTELTR 9
           QTELTR
Sbjct: 427 QTELTR 432
>XP_006718013
          Length = 1778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTQTELTR 9
           VTQT +TR
Sbjct: 454 VTQTGITR 461
>XP_006714572
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VTQTELTR 9
           +T+TELT+
Sbjct: 495 LTETELTK 502
>XP_005248442
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VTQTELTR 9
           +T+TELT+
Sbjct: 828 LTETELTK 835
>XP_005248441
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VTQTELTR 9
           +T+TELT+
Sbjct: 828 LTETELTK 835
>NP_001001924
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>NP_001001925
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>NP_722581
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVTQTELT 8
           +VT+TE+T
Sbjct: 406 QVTKTEIT 413
>NP_065928
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KVTQTELT 8
            K+T TE+T
Sbjct: 3580 KITATEVT 3587
>NP_001239542
          Length = 1957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1457 KPTQSSLTR 1465
>NP_001239541
          Length = 1978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1457 KPTQSSLTR 1465
>NP_001014972
          Length = 1978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1457 KPTQSSLTR 1465
>NP_055312
          Length = 1978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1457 KPTQSSLTR 1465
>XP_005256527
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KVTQTELT 8
            K+T TE+T
Sbjct: 3580 KITATEVT 3587
>XP_005273640
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273639
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273638
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273637
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273636
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273635
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_005273634
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVTQTELTR 9
           KVT+TE T+
Sbjct: 370 KVTETEDTQ 378
>XP_006712053
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVTQTELTR 9
           K TQ+ LTR
Sbjct: 946 KPTQSSLTR 954
>XP_005264320
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVTQTELTR 9
           K TQ+ LTR
Sbjct: 946 KPTQSSLTR 954
>XP_006712052
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVTQTELTR 9
           K TQ+ LTR
Sbjct: 946 KPTQSSLTR 954
>XP_005264319
          Length = 2049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1563 KPTQSSLTR 1571
>XP_005264318
          Length = 2084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVTQTELTR 9
            K TQ+ LTR
Sbjct: 1563 KPTQSSLTR 1571
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.115    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 350,729
Number of extensions: 430
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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