Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     509
NP_002833                                                              16    5631
NP_001154912                                                           16    5631
NP_149072                                                              16    5631
NP_001092289                                                           16    5631
NP_001180298                                                           16    5631
NP_000914                                                              16    5631
NP_001092288                                                           16    5631
XP_006723375                                                           16    5631
NP_004163                                                              16    7355
NP_055731                                                              16    7355
NP_001160167                                                           16    7355
NP_001276868                                                           16    7355
NP_001276869                                                           16    7355
NP_001438                                                              16    7355
NP_689652                                                              16    7355
NP_116124                                                              16    7355
NP_001269542                                                           16    7355
NP_065928                                                              16    7355
XP_005256527                                                           16    7355
XP_006719318                                                           16    7355
XP_006719317                                                           16    7355
XP_006719316                                                           16    7355
XP_006719315                                                           16    7355
XP_006719314                                                           16    7355
XP_006714824                                                           16    7355
XP_006714551                                                           16    7355
XP_005248399                                                           16    7355
NP_653319                                                              15    9605
NP_000916                                                              15    9605
NP_001166939                                                           15    9605
NP_060123                                                              15    9605
NP_776152                                                              15    9605
NP_004552                                                              15    9605
XP_006722555                                                           15    9605
XP_006722554                                                           15    9605
XP_006722553                                                           15    9605
XP_006722552                                                           15    9605
XP_006722551                                                           15    9605
XP_006722550                                                           15    9605
XP_006722549                                                           15    9605
XP_006722548                                                           15    9605
XP_005274075                                                           15    9605
XP_005274074                                                           15    9605
XP_005269575                                                           15    9605
XP_006713578                                                           15    9605
XP_005246710                                                           15    9605
NP_061921                                                              15    9605
NP_061751                                                              15    9605
NP_115782                                                              15    9605
>NP_004351
          Length = 882

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVTAADAPN 9
           KVT ADAPN
Sbjct: 397 KVTDADAPN 405
>NP_002833
          Length = 1115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTAADAPN 9
           +TAA APN
Sbjct: 559 LTAATAPN 566
>NP_001154912
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTAADAPN 9
           +TAA APN
Sbjct: 381 LTAATAPN 388
>NP_149072
          Length = 2240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KVTAADAPN 9
            KVT  D PN
Sbjct: 1438 KVTVDDLPN 1446
>NP_001092289
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KVTAADAP 8
           KVTA +AP
Sbjct: 171 KVTAEEAP 178
>NP_001180298
          Length = 2240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KVTAADAPN 9
            KVT  D PN
Sbjct: 1438 KVTVDDLPN 1446
>NP_000914
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KVTAADAP 8
           KVTA +AP
Sbjct: 277 KVTAEEAP 284
>NP_001092288
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KVTAADAP 8
           KVTA +AP
Sbjct: 245 KVTAEEAP 252
>XP_006723375
          Length = 1137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTAADAPN 9
           +TAA APN
Sbjct: 581 LTAATAPN 588
>NP_004163
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 163 RVTAADA 169
>NP_055731
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KVTAADAPN 9
            K TAA+AP+
Sbjct: 1335 KPTAANAPD 1343
>NP_001160167
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 163 RVTAADA 169
>NP_001276868
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 117 RVTAADA 123
>NP_001276869
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 163 RVTAADA 169
>NP_001438
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVTAADAPN 9
           K+TA+D  N
Sbjct: 639 KITASDGKN 647
>NP_689652
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 292 ITAAEAP 298
>NP_116124
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 505 ITAAEAP 511
>NP_001269542
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 399 ITAAEAP 405
>NP_065928
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KVTAADAP 8
            K+T+ DAP
Sbjct: 2014 KLTSVDAP 2021
>XP_005256527
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KVTAADAP 8
            K+T+ DAP
Sbjct: 2014 KLTSVDAP 2021
>XP_006719318
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 343 ITAAEAP 349
>XP_006719317
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 377 ITAAEAP 383
>XP_006719316
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 399 ITAAEAP 405
>XP_006719315
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 427 ITAAEAP 433
>XP_006719314
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTAADAP 8
           +TAA+AP
Sbjct: 498 ITAAEAP 504
>XP_006714824
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVTAADAPN 9
           K+TA+D  N
Sbjct: 639 KITASDGKN 647
>XP_006714551
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 163 RVTAADA 169
>XP_005248399
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVTAADA 7
           +VTAADA
Sbjct: 163 RVTAADA 169
>NP_653319
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TAADAPN 9
           T+AD PN
Sbjct: 319 TSADLPN 325
>NP_000916
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KVTAADAP 8
           +VT AD P
Sbjct: 324 RVTGADVP 331
>NP_001166939
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KVTAADAP 8
           +VT AD P
Sbjct: 306 RVTGADVP 313
>NP_060123
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>NP_776152
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           +ADAPN
Sbjct: 603 SADAPN 608
>NP_004552
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVTAADAPN 9
           KVT  D+P+
Sbjct: 106 KVTLGDSPS 114
>XP_006722555
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722554
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722553
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722552
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722551
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_006722550
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 296 ASDAPN 301
>XP_006722549
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 296 ASDAPN 301
>XP_006722548
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           A+DAPN
Sbjct: 297 ASDAPN 302
>XP_005274075
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVTAADAPN 9
          KVT  D+P+
Sbjct: 44 KVTLGDSPS 52
>XP_005274074
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVTAADAPN 9
          KVT  D+P+
Sbjct: 44 KVTLGDSPS 52
>XP_005269575
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           +ADAPN
Sbjct: 562 SADAPN 567
>XP_006713578
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TAADAPN 9
           T+AD PN
Sbjct: 319 TSADLPN 325
>XP_005246710
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           AAD+PN
Sbjct: 393 AADSPN 398
>NP_061921
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AADAPN 9
           AAD+PN
Sbjct: 393 AADSPN 398
>NP_061751
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTAADAPN 9
           VTA+DA N
Sbjct: 425 VTASDAGN 432
>NP_115782
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTAADAPN 9
           VTA+DA N
Sbjct: 425 VTASDAGN 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.111    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 487,596
Number of extensions: 653
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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