Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              20     299
XP_005250598                                                           20     299
NP_036292                                                              17    3301
NP_001265645                                                           17    3301
XP_005266987                                                           17    3301
XP_006715521                                                           17    3301
NP_064592                                                              16    5631
XP_005252384                                                           16    5631
NP_002102                                                              16    7355
NP_001196                                                              16    7355
NP_053582                                                              16    7355
NP_055026                                                              16    7355
XP_006716419                                                           16    7355
XP_005265931                                                           16    7355
XP_005265930                                                           16    7355
XP_005265929                                                           16    7355
NP_001123543                                                           15    9605
NP_001017928                                                           15    9605
NP_001399                                                              15    9605
NP_001361                                                              15    9605
NP_006867                                                              15    9605
XP_005258887                                                           15    9605
XP_005258886                                                           15    9605
XP_006723241                                                           15    9605
XP_006723240                                                           15    9605
XP_006723239                                                           15    9605
XP_005247165                                                           15    9605
XP_006712935                                                           15    9605
XP_006712934                                                           15    9605
XP_006712933                                                           15    9605
XP_006712019                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
NP_852118                                                              15    9605
NP_001123544                                                           15    9605
NP_037465                                                              15    9605
NP_004482                                                              15    9605
>NP_919047
          Length = 520

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSQTCKLA 9
           KVS+TCKLA
Sbjct: 364 KVSRTCKLA 372
>XP_005250598
          Length = 457

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSQTCKLA 9
           KVS+TCKLA
Sbjct: 301 KVSRTCKLA 309
>NP_036292
          Length = 621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSQTCKL 8
           +++QTCKL
Sbjct: 302 RLAQTCKL 309
>NP_001265645
          Length = 621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSQTCKL 8
           +++QTCKL
Sbjct: 302 RLAQTCKL 309
>XP_005266987
          Length = 597

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSQTCKL 8
           +++QTCKL
Sbjct: 302 RLAQTCKL 309
>XP_006715521
          Length = 621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSQTCKL 8
           +++QTCKL
Sbjct: 302 RLAQTCKL 309
>NP_064592
          Length = 1561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KVSQTCKL 8
            K+SQ C L
Sbjct: 1333 KISQVCSL 1340
>XP_005252384
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KVSQTCKL 8
           K+SQ C L
Sbjct: 613 KISQVCSL 620
>NP_002102
          Length = 3144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SQTCKLA 9
           S TCKLA
Sbjct: 822 SVTCKLA 828
>NP_001196
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSQTCKLA 9
           K + TCK+A
Sbjct: 97  KANLTCKIA 105
>NP_053582
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSQTCKLA 9
           K + TCK+A
Sbjct: 140 KANLTCKIA 148
>NP_055026
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SQTCKL 8
           +QTCKL
Sbjct: 171 TQTCKL 176
>XP_006716419
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KVSQTCKL 8
           K+SQ C L
Sbjct: 600 KISQMCSL 607
>XP_005265931
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SQTCKL 8
           +QTCKL
Sbjct: 171 TQTCKL 176
>XP_005265930
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SQTCKL 8
           +QTCKL
Sbjct: 171 TQTCKL 176
>XP_005265929
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SQTCKL 8
          +QTCKL
Sbjct: 92 TQTCKL 97
>NP_001123543
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KVSQTCK 7
           +VSQ CK
Sbjct: 202 RVSQQCK 208
>NP_001017928
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  SQTCK 7
          SQTCK
Sbjct: 50 SQTCK 54
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTCKLA 9
           Q+CKLA
Sbjct: 146 QSCKLA 151
>NP_001361
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    KVSQTCK 7
            KVS+ CK
Sbjct: 2873 KVSKACK 2879
>NP_006867
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KVSQTCKL 8
           ++SQ C+L
Sbjct: 349 RISQACEL 356
>XP_005258887
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KVSQTCK 7
          +VSQ CK
Sbjct: 91 RVSQQCK 97
>XP_005258886
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KVSQTCK 7
          +VSQ CK
Sbjct: 91 RVSQQCK 97
>XP_006723241
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KVSQTCK 7
           +VSQ CK
Sbjct: 151 RVSQQCK 157
>XP_006723240
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KVSQTCK 7
           +VSQ CK
Sbjct: 151 RVSQQCK 157
>XP_006723239
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KVSQTCK 7
           +VSQ CK
Sbjct: 151 RVSQQCK 157
>XP_005247165
          Length = 130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  SQTCK 7
          SQTCK
Sbjct: 36 SQTCK 40
>XP_006712935
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVSQTC 6
           +VSQTC
Sbjct: 887 EVSQTC 892
>XP_006712934
          Length = 1583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVSQTC 6
           +VSQTC
Sbjct: 783 EVSQTC 788
>XP_006712933
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVSQTC 6
           +VSQTC
Sbjct: 887 EVSQTC 892
>XP_006712019
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    KVSQTCK 7
            KVS+ CK
Sbjct: 2873 KVSKACK 2879
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTCKLA 9
           Q+CKLA
Sbjct: 146 QSCKLA 151
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTCKLA 9
           Q+CKLA
Sbjct: 146 QSCKLA 151
>NP_852118
          Length = 1684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVSQTC 6
           +VSQTC
Sbjct: 884 EVSQTC 889
>NP_001123544
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KVSQTCK 7
          +VSQ CK
Sbjct: 91 RVSQQCK 97
>NP_037465
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KVSQTCK 7
          +VSQ CK
Sbjct: 91 RVSQQCK 97
>NP_004482
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   SQTCK 7
           SQTCK
Sbjct: 806 SQTCK 810
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.117    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 510,951
Number of extensions: 336
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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