Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           20     299
NP_001257437                                                           20     299
NP_006281                                                              20     299
XP_006715618                                                           20     299
XP_005267176                                                           20     299
NP_057452                                                              18    1135
NP_115970                                                              16    5631
NP_003602                                                              16    5631
NP_065880                                                              16    5631
NP_001129392                                                           16    5631
NP_001193486                                                           16    5631
XP_005274663                                                           16    5631
XP_005274662                                                           16    5631
XP_005274661                                                           16    5631
XP_005274660                                                           16    5631
XP_005274659                                                           16    5631
XP_005274658                                                           16    5631
XP_005274657                                                           16    5631
XP_005274656                                                           16    5631
XP_005251580                                                           16    5631
XP_006715862                                                           16    5631
XP_005249952                                                           16    5631
XP_005249951                                                           16    5631
NP_000616                                                              16    7355
NP_003460                                                              16    7355
NP_004590                                                              16    7355
NP_001265432                                                           16    7355
NP_689926                                                              16    7355
NP_569056                                                              16    7355
NP_001193809                                                           16    7355
NP_001093633                                                           16    7355
NP_001265433                                                           16    7355
NP_001027449                                                           16    7355
NP_077278                                                              16    7355
NP_055061                                                              16    7355
NP_001138722                                                           16    7355
NP_001092049                                                           16    7355
XP_006726574                                                           16    7355
XP_006724446                                                           16    7355
XP_006724373                                                           16    7355
XP_005254186                                                           16    7355
NP_003686                                                              16    7355
NP_006456                                                              16    7355
NP_001184033                                                           15    9605
NP_005924                                                              15    9605
NP_000307                                                              15    9605
NP_001171673                                                           15    9605
NP_542411                                                              15    9605
NP_115583                                                              15    9605
NP_001275763                                                           15    9605
NP_001273897                                                           15    9605
NP_005345                                                              15    9605
NP_055238                                                              15    9605
NP_065823                                                              15    9605
XP_006722983                                                           15    9605
XP_005272021                                                           15    9605
XP_006714650                                                           15    9605
XP_005272020                                                           15    9605
XP_006714541                                                           15    9605
XP_005248375                                                           15    9605
XP_005265401                                                           15    9605
XP_005265400                                                           15    9605
XP_005265399                                                           15    9605
XP_006713335                                                           15    9605
NP_060504                                                              15    9605
>NP_001257436
          Length = 790

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSPTSSRF 9
           KVSPT+SRF
Sbjct: 643 KVSPTASRF 651
>NP_001257437
          Length = 790

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSPTSSRF 9
           KVSPT+SRF
Sbjct: 643 KVSPTASRF 651
>NP_006281
          Length = 790

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSPTSSRF 9
           KVSPT+SRF
Sbjct: 643 KVSPTASRF 651
>XP_006715618
          Length = 577

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSPTSSRF 9
           KVSPT+SRF
Sbjct: 430 KVSPTASRF 438
>XP_005267176
          Length = 790

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVSPTSSRF 9
           KVSPT+SRF
Sbjct: 643 KVSPTASRF 651
>NP_057452
          Length = 558

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KVSPTSSRF 9
          KV PTS+RF
Sbjct: 40 KVHPTSTRF 48
>NP_115970
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSPTSSR 8
           +++PTSSR
Sbjct: 304 EITPTSSR 311
>NP_003602
          Length = 1012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 116 KINPTSSLY 124
>NP_065880
          Length = 1423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSPTSSRF 9
           ++P SSRF
Sbjct: 230 ITPVSSRF 237
>NP_001129392
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSPTSSRF 9
           ++P SSRF
Sbjct: 230 ITPVSSRF 237
>NP_001193486
          Length = 1386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSPTSSRF 9
           ++P SSRF
Sbjct: 230 ITPVSSRF 237
>XP_005274663
          Length = 964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KVSPTSSRF 9
          K++PTSS +
Sbjct: 68 KINPTSSLY 76
>XP_005274662
          Length = 971

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 116 KINPTSSLY 124
>XP_005274661
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 116 KINPTSSLY 124
>XP_005274660
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 123 KINPTSSLY 131
>XP_005274659
          Length = 982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 123 KINPTSSLY 131
>XP_005274658
          Length = 1011

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 116 KINPTSSLY 124
>XP_005274657
          Length = 1018

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 123 KINPTSSLY 131
>XP_005274656
          Length = 1019

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVSPTSSRF 9
           K++PTSS +
Sbjct: 123 KINPTSSLY 131
>XP_005251580
          Length = 1422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSPTSSRF 9
           ++P SSRF
Sbjct: 229 ITPVSSRF 236
>XP_006715862
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSPTSSR 8
           +++PTSSR
Sbjct: 129 EITPTSSR 136
>XP_005249952
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSPTSSR 8
           +++PTSSR
Sbjct: 304 EITPTSSR 311
>XP_005249951
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KVSPTSSR 8
           +++PTSSR
Sbjct: 304 EITPTSSR 311
>NP_000616
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 745 SPTSSR 750
>NP_003460
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K++P S RF
Sbjct: 561 KLAPVSKRF 569
>NP_004590
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KVSPTS 6
           KVSPTS
Sbjct: 115 KVSPTS 120
>NP_001265432
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K+SP + RF
Sbjct: 322 KISPWTGRF 330
>NP_689926
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K+SP + RF
Sbjct: 322 KISPWTGRF 330
>NP_569056
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 202 SPTSSR 207
>NP_001193809
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 202 SPTSSR 207
>NP_001093633
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 111 SPTSSR 116
>NP_001265433
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K+SP + RF
Sbjct: 230 KISPWTGRF 238
>NP_001027449
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SPTSSRF 9
          +PTS+RF
Sbjct: 53 APTSTRF 59
>NP_077278
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SPTSSRF 9
          +PTS+RF
Sbjct: 53 APTSTRF 59
>NP_055061
          Length = 3014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SPTSSR 8
            SPTSSR
Sbjct: 2960 SPTSSR 2965
>NP_001138722
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SPTSSRF 9
           SPTSS F
Sbjct: 95  SPTSSAF 101
>NP_001092049
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 193 SPTSSR 198
>XP_006726574
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 397 SPTSSR 402
>XP_006724446
          Length = 3019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SPTSSR 8
            SPTSSR
Sbjct: 2960 SPTSSR 2965
>XP_006724373
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  KVSPTS 6
          KVSPTS
Sbjct: 85 KVSPTS 90
>XP_005254186
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 543 SPTSSR 548
>NP_003686
          Length = 128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  VSPTSSRF 9
          V P SSRF
Sbjct: 37 VCPASSRF 44
>NP_006456
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SPTSSR 8
           SPTSSR
Sbjct: 542 SPTSSR 547
>NP_001184033
          Length = 3972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K+SP  S+F
Sbjct: 277 KLSPLKSKF 285
>NP_005924
          Length = 3969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K+SP  S+F
Sbjct: 277 KLSPLKSKF 285
>NP_000307
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K +PT SR+
Sbjct: 95  KEAPTGSRY 103
>NP_001171673
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K +PT SR+
Sbjct: 95  KEAPTGSRY 103
>NP_542411
          Length = 1736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           +V PT+ RF
Sbjct: 319 QVPPTADRF 327
>NP_115583
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVSPTSSRF 9
          K++P  SRF
Sbjct: 42 KIAPGHSRF 50
>NP_001275763
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVSPTSSRF 9
          K++P  SRF
Sbjct: 42 KIAPGHSRF 50
>NP_001273897
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SPTSSRF 9
          +PTSS+F
Sbjct: 74 TPTSSQF 80
>NP_005345
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SPTSSRF 9
           +PTSS+F
Sbjct: 117 TPTSSQF 123
>NP_055238
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KVSPTSS 7
           KVSP SS
Sbjct: 485 KVSPASS 491
>NP_065823
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VSPTSS 7
           VSPTSS
Sbjct: 375 VSPTSS 380
>XP_006722983
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVSPTSSRF 9
          K++P  SRF
Sbjct: 42 KIAPGHSRF 50
>XP_005272021
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KVSPTSS 7
           KVSP SS
Sbjct: 107 KVSPASS 113
>XP_006714650
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KVSPTSS 7
           KVSP SS
Sbjct: 456 KVSPASS 462
>XP_005272020
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KVSPTSS 7
           KVSP SS
Sbjct: 485 KVSPASS 491
>XP_006714541
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VSPTSSR 8
          + PTSSR
Sbjct: 80 IEPTSSR 86
>XP_005248375
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VSPTSSR 8
          + PTSSR
Sbjct: 79 IEPTSSR 85
>XP_005265401
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVSPTSSRF 9
          K +PT SR+
Sbjct: 64 KEAPTGSRY 72
>XP_005265400
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KVSPTSSRF 9
          K +PT SR+
Sbjct: 77 KEAPTGSRY 85
>XP_005265399
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K +PT SR+
Sbjct: 95  KEAPTGSRY 103
>XP_006713335
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVSPTSSRF 9
           K +PT SR+
Sbjct: 108 KEAPTGSRY 116
>NP_060504
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VSPTSSR 8
          + PTSSR
Sbjct: 80 IEPTSSR 86
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.116    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 699,936
Number of extensions: 875
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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