Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     390
NP_001087241                                                           20     390
XP_006714101                                                           20     390
XP_005265799                                                           20     390
XP_005265798                                                           20     390
XP_005265797                                                           20     390
NP_055750                                                              17    3301
NP_148978                                                              17    3301
NP_006192                                                              17    3301
XP_006724598                                                           17    3301
XP_006724597                                                           17    3301
XP_005272672                                                           17    3301
XP_005272671                                                           17    3301
XP_006711286                                                           17    3301
XP_005245025                                                           17    3301
XP_005245024                                                           17    3301
XP_006711285                                                           17    3301
XP_006711284                                                           17    3301
XP_006711283                                                           17    3301
XP_006711282                                                           17    3301
XP_006711281                                                           17    3301
XP_006711280                                                           17    3301
XP_006711279                                                           17    3301
XP_006711278                                                           17    3301
XP_006711277                                                           17    3301
XP_005245023                                                           17    3301
XP_006711276                                                           17    3301
XP_006711275                                                           17    3301
NP_001163931                                                           17    3301
NP_001229392                                                           17    4312
NP_006411                                                              17    4312
XP_006723746                                                           17    4312
XP_005260309                                                           17    4312
NP_002649                                                              16    7355
NP_001138503                                                           16    7355
NP_002438                                                              16    7355
NP_001231866                                                           16    7355
NP_001074003                                                           16    7355
NP_001254824                                                           16    7355
NP_597712                                                              16    7355
XP_005261390                                                           16    7355
XP_005261387                                                           16    7355
XP_005261386                                                           16    7355
XP_006724195                                                           16    7355
XP_005261385                                                           16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_006717956                                                           16    7355
XP_005265227                                                           16    7355
NP_001255213                                                           15    9605
NP_001028222                                                           15    9605
NP_079474                                                              15    9605
NP_079337                                                              15    9605
XP_005272554                                                           15    9605
XP_006719676                                                           15    9605
XP_006719675                                                           15    9605
NP_699189                                                              15    9605
NP_001123357                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>NP_001087241
          Length = 972

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>XP_006714101
          Length = 526

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>XP_005265799
          Length = 973

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>XP_005265798
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>XP_005265797
          Length = 977

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KVRPAFKVV 9
           KVRPAFK V
Sbjct: 203 KVRPAFKAV 211
>NP_055750
          Length = 1048

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPA+KVV
Sbjct: 856 RPAYKVV 862
>NP_148978
          Length = 502

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 492 RPAFRVV 498
>NP_006192
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 486 RPAFRVV 492
>XP_006724598
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 486 RPAFRVV 492
>XP_006724597
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 486 RPAFRVV 492
>XP_005272672
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 486 RPAFRVV 492
>XP_005272671
          Length = 543

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 533 RPAFRVV 539
>XP_006711286
          Length = 1021

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPA+KVV
Sbjct: 829 RPAYKVV 835
>XP_005245025
          Length = 1156

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPA+KVV
Sbjct: 964 RPAYKVV 970
>XP_005245024
          Length = 1177

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPA+KVV
Sbjct: 985 RPAYKVV 991
>XP_006711285
          Length = 1193

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1001 RPAYKVV 1007
>XP_006711284
          Length = 1193

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1001 RPAYKVV 1007
>XP_006711283
          Length = 1193

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1001 RPAYKVV 1007
>XP_006711282
          Length = 1227

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1035 RPAYKVV 1041
>XP_006711281
          Length = 1233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1041 RPAYKVV 1047
>XP_006711280
          Length = 1251

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1059 RPAYKVV 1065
>XP_006711279
          Length = 1254

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1062 RPAYKVV 1068
>XP_006711278
          Length = 1256

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1064 RPAYKVV 1070
>XP_006711277
          Length = 1280

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1109 RPAYKVV 1115
>XP_005245023
          Length = 1281

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1089 RPAYKVV 1095
>XP_006711276
          Length = 1283

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1091 RPAYKVV 1097
>XP_006711275
          Length = 1301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RPAFKVV 9
            RPA+KVV
Sbjct: 1109 RPAYKVV 1115
>NP_001163931
          Length = 570

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RPAFKVV 9
           RPAF+VV
Sbjct: 560 RPAFRVV 566
>NP_001229392
          Length = 262

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VRPAFK 7
           VRPAFK
Sbjct: 123 VRPAFK 128
>NP_006411
          Length = 1785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           VRP FK+V
Sbjct: 890 VRPMFKLV 897
>XP_006723746
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           VRP FK+V
Sbjct: 282 VRPMFKLV 289
>XP_005260309
          Length = 1784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           VRP FK+V
Sbjct: 889 VRPMFKLV 896
>NP_002649
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           +RP FK++
Sbjct: 173 LRPRFKII 180
>NP_001138503
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           +RP FK++
Sbjct: 156 LRPRFKII 163
>NP_002438
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRPAFKVV 9
            VRP F+V+
Sbjct: 1330 VRPTFRVL 1337
>NP_001231866
          Length = 1351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRPAFKVV 9
            VRP F+V+
Sbjct: 1281 VRPTFRVL 1288
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KVRPAFK 7
           ++RP+FK
Sbjct: 967 RIRPSFK 973
>NP_001254824
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>NP_597712
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_005261390
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_005261387
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_005261386
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_006724195
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_005261385
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VRPAFKVV 9
          VRP +KV+
Sbjct: 77 VRPTYKVM 84
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KVRPAFK 7
           ++RP+FK
Sbjct: 967 RIRPSFK 973
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KVRPAFK 7
           ++RP+FK
Sbjct: 967 RIRPSFK 973
>XP_006717956
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VRPAFKVV 9
           +RP FK++
Sbjct: 173 LRPRFKII 180
>XP_005265227
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRPAFKVV 9
            VRP F+V+
Sbjct: 1331 VRPTFRVL 1338
>NP_001255213
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RPAFKVV 9
          +PAFKV+
Sbjct: 14 QPAFKVL 20
>NP_001028222
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KVRPAFKVV 9
           KVRP F  V
Sbjct: 370 KVRPLFNPV 378
>NP_079474
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KVRPAFKVV 9
           KVRP F  V
Sbjct: 370 KVRPLFNPV 378
>NP_079337
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RPAFKVV 9
          +PAFKV+
Sbjct: 14 QPAFKVL 20
>XP_005272554
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RPAFKVV 9
          +PAFKV+
Sbjct: 14 QPAFKVL 20
>XP_006719676
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KVRPAFKVV 9
           KVRP F  V
Sbjct: 370 KVRPLFNPV 378
>XP_006719675
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KVRPAFKVV 9
           KVRP F  V
Sbjct: 370 KVRPLFNPV 378
>NP_699189
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RPAFKV 8
           RPAF+V
Sbjct: 340 RPAFRV 345
>NP_001123357
          Length = 179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VRPAFK 7
           V+PAFK
Sbjct: 115 VKPAFK 120
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.143    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 582,126
Number of extensions: 675
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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