Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              19     869
XP_006714104                                                           19     869
XP_005265800                                                           19     869
XP_006714103                                                           19     869
XP_006714102                                                           19     869
NP_001091954                                                           17    4312
NP_003750                                                              17    4312
NP_079446                                                              17    4312
NP_079146                                                              17    4312
XP_006714462                                                           17    4312
XP_006714461                                                           17    4312
XP_005265761                                                           17    4312
NP_037524                                                              16    7355
XP_005264331                                                           16    7355
NP_006423                                                              15    9605
NP_000907                                                              15    9605
NP_112582                                                              15    9605
NP_612429                                                              15    9605
NP_597722                                                              15    9605
NP_001092085                                                           15    9605
NP_001092084                                                           15    9605
NP_001273965                                                           15    9605
NP_001258755                                                           15    9605
XP_005267356                                                           15    9605
XP_006720067                                                           15    9605
XP_005269225                                                           15    9605
XP_006719686                                                           15    9605
XP_005269223                                                           15    9605
XP_005252339                                                           15    9605
NP_116198                                                              15    9605
>NP_006197
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KVPSIKLV 8
           KVPSIKLV
Sbjct: 265 KVPSIKLV 272
>XP_006714104
          Length = 832

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KVPSIKLV 8
           KVPSIKLV
Sbjct: 290 KVPSIKLV 297
>XP_005265800
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KVPSIKLV 8
           KVPSIKLV
Sbjct: 265 KVPSIKLV 272
>XP_006714103
          Length = 1111

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KVPSIKLV 8
           KVPSIKLV
Sbjct: 287 KVPSIKLV 294
>XP_006714102
          Length = 1114

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KVPSIKLV 8
           KVPSIKLV
Sbjct: 290 KVPSIKLV 297
>NP_001091954
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KVPSIKL 7
            KVPSIK+
Sbjct: 1041 KVPSIKI 1047
>NP_003750
          Length = 1035

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KVPSIKL 7
            KVPSIK+
Sbjct: 997  KVPSIKI 1003
>NP_079446
          Length = 979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KVPSIKLV 8
           KVP IKLV
Sbjct: 612 KVPIIKLV 619
>NP_079146
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KVPSIKLV 8
           KVP IKLV
Sbjct: 612 KVPIIKLV 619
>XP_006714462
          Length = 1084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KVPSIKL 7
            KVPSIK+
Sbjct: 1046 KVPSIKI 1052
>XP_006714461
          Length = 1099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KVPSIKL 7
            KVPSIK+
Sbjct: 1061 KVPSIKI 1067
>XP_005265761
          Length = 1110

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KVPSIKL 7
            KVPSIK+
Sbjct: 1072 KVPSIKI 1078
>NP_037524
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KVPSIKLVS 9
           +VPS+KL++
Sbjct: 329 EVPSLKLLA 337
>XP_005264331
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KVPSIKLVS 9
           +VPS+KL++
Sbjct: 329 EVPSLKLLA 337
>NP_006423
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PSIKLV 8
           PSIKLV
Sbjct: 120 PSIKLV 125
>NP_000907
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVPSIKLVS 9
           +V S+KL+S
Sbjct: 259 RVSSVKLIS 267
>NP_112582
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 629 KVPTLKL 635
>NP_612429
          Length = 5795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVPSIKLVS 9
            K+P IKL S
Sbjct: 4954 KMPKIKLPS 4962
>NP_597722
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           K+P++KL
Sbjct: 448 KIPAVKL 454
>NP_001092085
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 629 KVPTLKL 635
>NP_001092084
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 629 KVPTLKL 635
>NP_001273965
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           K+P++KL
Sbjct: 476 KIPAVKL 482
>NP_001258755
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 316 KVPTLKL 322
>XP_005267356
          Length = 5695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KVPSIKLVS 9
            K+P IKL S
Sbjct: 4854 KMPKIKLPS 4862
>XP_006720067
          Length = 174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PSIKLV 8
           PSIKLV
Sbjct: 120 PSIKLV 125
>XP_005269225
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 316 KVPTLKL 322
>XP_006719686
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 520 KVPTLKL 526
>XP_005269223
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVPSIKL 7
           KVP++KL
Sbjct: 641 KVPTLKL 647
>XP_005252339
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVPSIK 6
           KVPS+K
Sbjct: 96  KVPSVK 101
>NP_116198
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KVPSIK 6
           KVPS+K
Sbjct: 96  KVPSVK 101
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.129    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 612,345
Number of extensions: 904
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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