Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              21     229
NP_001075109                                                           21     229
NP_001243415                                                           16    5631
NP_001243417                                                           16    5631
NP_004478                                                              16    5631
NP_001243416                                                           16    5631
NP_060654                                                              16    5631
XP_006713654                                                           16    5631
XP_006713653                                                           16    5631
XP_005247430                                                           16    5631
XP_005247429                                                           16    5631
XP_006713652                                                           16    5631
XP_006713651                                                           16    5631
XP_006713650                                                           16    5631
XP_005247428                                                           16    5631
XP_005265352                                                           16    5631
NP_005870                                                              16    5631
NP_001367                                                              16    7355
NP_001002814                                                           16    7355
NP_079427                                                              16    7355
NP_055719                                                              16    7355
NP_116253                                                              16    7355
NP_001241872                                                           16    7355
NP_001129069                                                           16    7355
NP_060554                                                              16    7355
NP_055325                                                              16    7355
NP_149015                                                              16    7355
XP_005269686                                                           16    7355
XP_006715989                                                           16    7355
XP_005264484                                                           16    7355
XP_005264483                                                           16    7355
XP_005264480                                                           16    7355
XP_005264478                                                           16    7355
XP_005264475                                                           16    7355
NP_000375                                                              15    9605
NP_006633                                                              15    9605
NP_003195                                                              15    9605
NP_078863                                                              15    9605
NP_055178                                                              15    9605
NP_653258                                                              15    9605
NP_001170949                                                           15    9605
NP_001264984                                                           15    9605
NP_002469                                                              15    9605
NP_001170950                                                           15    9605
NP_059115                                                              15    9605
NP_001274324                                                           15    9605
XP_006725036                                                           15    9605
XP_006725035                                                           15    9605
XP_006725032                                                           15    9605
XP_006725031                                                           15    9605
XP_006725029                                                           15    9605
XP_006725028                                                           15    9605
XP_006725027                                                           15    9605
XP_006724682                                                           15    9605
XP_005262138                                                           15    9605
XP_005257472                                                           15    9605
XP_005257470                                                           15    9605
XP_005257469                                                           15    9605
XP_005257468                                                           15    9605
XP_005257467                                                           15    9605
XP_005266395                                                           15    9605
XP_006712547                                                           15    9605
XP_005273080                                                           15    9605
XP_006711793                                                           15    9605
XP_005273075                                                           15    9605
XP_005273073                                                           15    9605
XP_005273070                                                           15    9605
XP_006711791                                                           15    9605
XP_006711790                                                           15    9605
XP_005271253                                                           15    9605
XP_005271252                                                           15    9605
XP_005271251                                                           15    9605
NP_005584                                                              15    9605
>NP_008835
          Length = 4128

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KVEFMRNEL 9
            KVEF+RNEL
Sbjct: 3691 KVEFLRNEL 3699
>NP_001075109
          Length = 4097

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KVEFMRNEL 9
            KVEF+RNEL
Sbjct: 3691 KVEFLRNEL 3699
>NP_001243415
          Length = 3269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 816 KIEVLQNEL 824
>NP_001243417
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 736 KIEVLQNEL 744
>NP_004478
          Length = 3259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 811 KIEVLQNEL 819
>NP_001243416
          Length = 3225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 777 KIEVLQNEL 785
>NP_060654
          Length = 186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           K+E  RNEL
Sbjct: 103 KIEASRNEL 111
>XP_006713654
          Length = 3189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 736 KIEVLQNEL 744
>XP_006713653
          Length = 3223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 775 KIEVLQNEL 783
>XP_005247430
          Length = 3228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 775 KIEVLQNEL 783
>XP_005247429
          Length = 3230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 777 KIEVLQNEL 785
>XP_006713652
          Length = 3263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 810 KIEVLQNEL 818
>XP_006713651
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 811 KIEVLQNEL 819
>XP_006713650
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 816 KIEVLQNEL 824
>XP_005247428
          Length = 3269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           K+E ++NEL
Sbjct: 816 KIEVLQNEL 824
>XP_005265352
          Length = 163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           K+E  RNEL
Sbjct: 103 KIEASRNEL 111
>NP_005870
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EFMRNEL 9
          EF++NEL
Sbjct: 77 EFLKNEL 83
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KVEFMRNEL 9
            +VE +RNEL
Sbjct: 3408 RVEPLRNEL 3416
>NP_001002814
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++FMRN +
Sbjct: 146 IQFMRNNM 153
>NP_079427
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++FMRN +
Sbjct: 146 IQFMRNNM 153
>NP_055719
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++FMRN +
Sbjct: 140 IQFMRNNM 147
>NP_116253
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VEFMRNE 8
          VEF++NE
Sbjct: 88 VEFIKNE 94
>NP_001241872
          Length = 1796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>NP_001129069
          Length = 1870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>NP_060554
          Length = 1843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>NP_055325
          Length = 4935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EFMRNEL 9
            EF+RN+L
Sbjct: 1576 EFIRNQL 1582
>NP_149015
          Length = 5142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EFMRNEL 9
            EF+RN+L
Sbjct: 1576 EFIRNQL 1582
>XP_005269686
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++FMRN +
Sbjct: 140 IQFMRNNM 147
>XP_006715989
          Length = 5148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EFMRNEL 9
            EF+RN+L
Sbjct: 1576 EFIRNQL 1582
>XP_005264484
          Length = 955

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>XP_005264483
          Length = 1311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>XP_005264480
          Length = 1842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>XP_005264478
          Length = 1844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>XP_005264475
          Length = 2027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE + NE+
Sbjct: 506 KVEILENEI 514
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EFMRNEL 9
            EF++NEL
Sbjct: 4361 EFIQNEL 4367
>NP_006633
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 242 QLKFLRNDL 250
>NP_003195
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 700 KVEFLRS 706
>NP_078863
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VEFMRN 7
           V+FMRN
Sbjct: 268 VDFMRN 273
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VEFMRN 7
            VEF+RN
Sbjct: 3583 VEFLRN 3588
>NP_653258
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           +V+F+ NEL
Sbjct: 611 EVKFIENEL 619
>NP_001170949
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           +V+F+ NEL
Sbjct: 553 EVKFIENEL 561
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VEFMRN 7
            VEF+RN
Sbjct: 3436 VEFLRN 3441
>NP_002469
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE +RN +
Sbjct: 146 KVEILRNAI 154
>NP_001170950
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           +V+F+ NEL
Sbjct: 611 EVKFIENEL 619
>NP_059115
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VEFMRNE 8
           VEF+RN+
Sbjct: 167 VEFIRNK 173
>NP_001274324
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++F+RN L
Sbjct: 650 IQFLRNSL 657
>XP_006725036
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 242 QLKFLRNDL 250
>XP_006725035
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 252 QLKFLRNDL 260
>XP_006725032
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 101 QLKFLRNDL 109
>XP_006725031
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 144 QLKFLRNDL 152
>XP_006725029
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 199 QLKFLRNDL 207
>XP_006725028
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 209 QLKFLRNDL 217
>XP_006725027
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 252 QLKFLRNDL 260
>XP_006724682
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           +V+F+ NEL
Sbjct: 553 EVKFIENEL 561
>XP_005262138
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVEFMRNEL 9
           +V+F+ NEL
Sbjct: 611 EVKFIENEL 619
>XP_005257472
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 659 KVEFLRS 665
>XP_005257470
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 670 KVEFLRS 676
>XP_005257469
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 670 KVEFLRS 676
>XP_005257468
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 689 KVEFLRS 695
>XP_005257467
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KVEFMRN 7
           KVEF+R+
Sbjct: 700 KVEFLRS 706
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VEFMRN 7
            VEF+RN
Sbjct: 3592 VEFLRN 3597
>XP_006712547
          Length = 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEFMRNEL 9
           ++F+RN L
Sbjct: 647 IQFLRNSL 654
>XP_005273080
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 242 QLKFLRNDL 250
>XP_006711793
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 252 QLKFLRNDL 260
>XP_005273075
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 101 QLKFLRNDL 109
>XP_005273073
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 144 QLKFLRNDL 152
>XP_005273070
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 199 QLKFLRNDL 207
>XP_006711791
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 209 QLKFLRNDL 217
>XP_006711790
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KVEFMRNEL 9
           +++F+RN+L
Sbjct: 252 QLKFLRNDL 260
>XP_005271253
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VEFMRN 7
           V+FMRN
Sbjct: 195 VDFMRN 200
>XP_005271252
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VEFMRN 7
           V+FMRN
Sbjct: 237 VDFMRN 242
>XP_005271251
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VEFMRN 7
           V+FMRN
Sbjct: 238 VDFMRN 243
>NP_005584
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KVEFMRNEL 9
           KVE +RN +
Sbjct: 120 KVEILRNAI 128
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.138    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 401,072
Number of extensions: 891
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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